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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Flotillin 1

flotillin-1, flotillin
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: caveolin-1, CAN, V1a, Actin, HAD
Papers using flotillin-1 antibodies
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation
Supplier
Araki Wataru et al., In Brain and Behavior, 2010
... Rabbit polyclonal antibodies against flotillin-1 were purchased from IBL (Gunma, Japan) and Sigma-Aldrich ...
A simplified method for quantifying cell migration/wound healing in 96-well plates
Supplier
Jia W et al., In Cell Death & Disease, 2009
... Flotillin-1 antibody was purchased from Abcam, Inc ...
A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis*
Supplier
Hobbs Helen H. et al., In The Journal of Biological Chemistry, 2005
... (catalog number 10R-All7a) and flotillin (catalog number 610821) were obtained from Fitzgerald Industries International (Acton, MA) ...
G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells.
Supplier
Keen James, In PLoS ONE, 2004
... Biosite, Täby, Sweden); mouse anti-early endosomal antigen (EEA) 1, mouse anti-Hsp90, mouse anti-flotillin 1, mouse anti-flotillin 2 (BD Biosciences Transduction Laboratories, Lexington, KY); ...
Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells.
Supplier
Bozza Patricia T., In PLoS ONE, 2004
... FN80 coated culture slides and monoclonal antibodies against p85a-PI3K, Flotillin-1 and –2 were purchased from BD Biosciences (Heidelberg, Germany) ...
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Papers on flotillin-1
Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway.
New
Roberts et al., San Antonio, United States. In Neurosci Lett, Feb 2016
ERα was found in the plasma membrane of astrocyte cultures and colocalized with the lipid raft marker, flotillin-1.
Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4-trafficking in lipid rafts via NADPH oxidase activation.
New
Chatterjee et al., United States. In Am J Physiol Gastrointest Liver Physiol, Jan 2016
Mechanistically, SSnB decreased TLR4 trafficking to the lipid rafts, a phenomenon described by the colocalization of TLR4 and lipid raft marker flotillin-2 in tissues and immortalized Kupffer cells.
Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-β signaling in nasopharyngeal carcinoma.
New
Lin et al., Guangzhou, China. In Oncotarget, Jan 2016
Herein, we report that flotillin-1 (FLOT1), a component of lipid raft, which was reported to be involved in tumor progression, was robustly upregulated in the NPC samples with lymph node metastasis.
Molecular identification and characterization of prohibitin from Echinococcus granulosus.
New
Yang et al., Chengdu, China. In Parasitol Res, Jan 2016
We found that EgPHB is a conserved SPFH (stomatin, prohibitin, flotillin, and HflK/C) domain-containing protein, consisting of 289 amino acids, which shares 42.66-99.31
Proteomic Analysis of Lipid Raft-Like Detergent-Resistant Membranes of Lens Fiber Cells.
New
Schey et al., In Invest Ophthalmol Vis Sci, Jan 2016
Lipid raft markers flotillin-1 and flotillin-2 and a significant fraction of AQP0, MP20, and AQP5 were found in the DRM fraction and were highly sensitive to cholesterol removal.
Flotillin-2 Gene Is Associated with Coronary Artery Disease in Chinese Han Population.
New
Ma et al., Ürümqi, China. In Genet Test Mol Biomarkers, Dec 2015
BACKGROUND: Flotillin-2, an important protein of vesicular endocytosis, is commonly used as a marker protein for lipid microdomains.
Differences between calcium-stimulated and storage-induced erythrocyte-derived microvesicles.
New
Lion et al., Switzerland. In Transfus Apher Sci, Oct 2015
Nevertheless, their content in proteins can differ and a few differences in terms of lipid raft proteins, notably stomatin and flotillin-2, have been reported.
Membrane nanodomains in plants: capturing form, function, and movement.
Review
New
Murphy et al., College Park, United States. In J Exp Bot, Mar 2015
In addition to the highly conserved flotillin and remorin markers, some members of the B and G subclasses of ATP binding cassette transporters have emerged as functional markers for plant nanodomains.
Flotillins in intercellular adhesion - from cellular physiology to human diseases.
Review
Gauthier-Rouvière et al., Montpellier, France. In J Cell Sci, 2015
Flotillin 1 and 2 are ubiquitous and highly conserved proteins.
Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway.
Review
Thomas et al., Atlanta, United States. In J Cell Physiol, 2014
Prohibitins are members of a highly conserved protein family containing the stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (also known as the prohibitin [PHB] domain) found in unicellular eukaryotes, fungi, plants, animals, and humans.
Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis.
Review
Harashima et al., Sapporo, Japan. In Mol Ther, 2013
These include caveolae-mediated, flotillin-dependent, GTPase regulator associated with focal adhesion kinase-1 (GRAF1)-dependent, adenosine diphosphate-ribosylation factor 6 (Arf6)-dependent, and RhoA-dependent endocytic pathways.
The evolving field of human papillomavirus receptor research: a review of binding and entry.
Review
Kast et al., Los Angeles, United States. In J Virol, 2013
Subsequently, clathrin-, caveolin-, lipid raft-, flotillin-, cholesterol-, and dynamin-independent endocytosis of HPV16 occurs.
Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling.
GeneRIF
Tikkanen et al., Gießen, Germany. In J Biol Chem, 2012
receptor-tyrosine kinases may also rely on flotillin-1 upon activation, thus suggesting a general role for flotillin-1 as a novel factor in receptor-tyrosine kinase/MAP kinase signaling.
Flotillin-1 (Reggie-2) contributes to Chlamydia pneumoniae growth and is associated with bacterial inclusion.
GeneRIF
Lahesmaa et al., Turku, Finland. In Infect Immun, 2012
Chlamydia pneumoniae intracellular growth was attenuated in the flotillin-1-silenced cells.
Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2.
GeneRIF
Tikkanen et al., Gießen, Germany. In Plos One, 2011
a novel signaling network containing FRS2, CAP and flotillin-1
Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a.
GeneRIF
Song et al., Guangzhou, China. In Clin Cancer Res, 2011
FLOT1 plays an important role in promoting proliferation and tumorigenesis of human breast cancer and may represent a novel prognostic biomarker and therapeutic target for the disease.
Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT.
GeneRIF
Yamamoto et al., New York City, United States. In Nat Neurosci, 2011
Flot1-enriched membrane microdomains are required for protein kinase C-regulated internalization of the DA transporter (DAT) and the glial glutamate transporter EAAT2.
Mechanisms of endocytosis.
Review
Impact
McMahon et al., Cambridge, United Kingdom. In Annu Rev Biochem, 2008
These clathrin-independent pathways include the CLIC/GEEC endocytic pathway, arf6-dependent endocytosis, flotillin-dependent endocytosis, macropinocytosis, circular doral ruffles, phagocytosis, and trans-endocytosis.
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells.
Impact
GeneRIF
Nichols et al., Cambridge, United Kingdom. In Nat Cell Biol, 2006
Flotillin-1 small interfering RNA (siRNA) inhibited both clathrin-independent uptake of cholera toxin and endocytosis of a GPI-linked protein. We propose that flotillin-1 is one determinant of a clathrin-independent endocytic pathway in mammalian cells.
CAP defines a second signalling pathway required for insulin-stimulated glucose transport.
Impact
Saltiel et al., Ann Arbor, United States. In Nature, 2000
Here, to identify a molecular mechanism underlying this subcellular redistribution, we screened a yeast two-hybrid library using the amino-terminal region of CAP and identified the caveolar protein flotillin.
More papers using flotillin-1 antibodies
Regulation of ADAM12 cell-surface expression by protein kinase C epsilon.
Supplier
Huard Johnny, In PLoS ONE, 2003
... Anti-caveolin-1 and anti-flotillin-1 antibodies were purchased from BD Biosciences (Franklin Lakes, NJ, ...
Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy.
Supplier
McFadden Grant, In PLoS Pathogens, 1998
... Ab was from Molecular Probes (Eugene, OR), DC-SIGN mAb (AZN-D1) was from Beckman-Coulter (Fullerton, CA), flotillin-1 (Flot-1) rabbit polyclonal Ab was from Abcam (Cambridge, UK) and Flot-1 ...
Surfactant release in excised rat lung is stimulated by air inflation.
Supplier
Morty Rory Edward, In PLoS ONE, 1980
... Monoclonal mouse anti-flotillin-1 antibody was from BD Biosciences (San Jose, CA), polyclonal ...
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