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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Friend leukemia virus integration 1

FLI-1
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: EWS, CAN, POLYMERASE, CD99, HAD
Papers using FLI-1 antibodies
ERG upregulation and related ETS transcription factors in prostate cancer
Supplier
Jin Dong-Yan, In PLoS ONE, 2006
... Exogenous miRNA and/or Fli-1 shRNA productions were induced by adding 100 ng/ml of Doxycycline (Dox) (Clontech, Saint-Germain-en-Laye, France) ...
Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development
Supplier
Kimmel Charles B et al., In PLoS Biology, 1998
... fli1-GFP albino transgenic fish are the same ...
Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes
Supplier
Crosier Phil et al., In BMC Developmental Biology, 1995
... fli1::EGFP compound transgenic larva, anterior to left ...
Papers on FLI-1
High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
New
Sepulveda et al., New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.
New
Caplen et al., Nashville, United States. In Cell Rep, Feb 2016
UNASSIGNED: Ewing sarcoma cells depend on the EWS-FLI1 fusion transcription factor for cell survival.
Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway.
Review
New
Gelderblom et al., Leiden, Netherlands. In Eur J Cancer, Feb 2016
IGF-1R: The IGF-1R pathway is known to be deregulated by the EWSR1-FLI1 translocation which makes it a potential target for therapy.
Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH.
New
Antonescu et al., Kayseri, Turkey. In Genes Chromosomes Cancer, Jan 2016
UNASSIGNED: The genetics of Ewing sarcoma (ES) are characterized by a canonical fusion involving EWSR1 gene and a member of the ETS family of transcription factors, such as FLI1 and ERG.
Efficient extravasation of tumor-repopulating cells depends on cell deformability.
New
Wang et al., Wuhan, China. In Sci Rep, Dec 2015
Here we show that when injected into the yolk of a 2 day-post-fertilization (dpf) embryo of Tg (fli1:EGFP or kdrl:mCherry) zebrafish, TRCs are much more efficient in surviving and growing at various secondary sites to generate micrometastasis and metastatic colonization than control melanoma cells that are grown on rigid plastic.
Primary Ewing Family of Tumors of the Jaw Has a Better Prognosis Compared to Tumors of Extragnathic Sites.
New
Estilo et al., Ann Arbor, United States. In J Oral Maxillofac Surg, Dec 2015
All cases were positive for CD99, and 3 patients with genetic confirmation were positive for EWS-FLI1 fusion or EWSR1 gene rearrangement.
The Molecular Taxonomy of Primary Prostate Cancer.
New
Impact
Cancer Genome Atlas Research Network et al., In Cell, Dec 2015
Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1).
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.
Review
New
Impact
Oberlin et al., Villejuif, France. In J Clin Oncol, Oct 2015
The many insights into the biology of the EWS-FLI1 protein in the initiation and progression of ES remain to be translated into novel therapeutic strategies.
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.
New
Impact
Delattre et al., Paris, France. In Nat Genet, Sep 2015
Ewing sarcoma is characterized by fusions between EWSR1 and members of the ETS gene family, usually EWSR1-FLI1, leading to the generation of oncogenic transcription factors that bind DNA at GGAA motifs.
Linking germline and somatic variation in Ewing sarcoma.
New
Impact
Davis et al., Chapel Hill, United States. In Nat Genet, Sep 2015
A new study links a germline variant to Ewing sarcoma disease susceptibility and EWSR1-FLI1-mediated gene activation.
[Epithelioid hemangioendothelioma: a clinicopathologic analysis of 13 cases].
New
Fan et al., Nanjing, China. In Zhonghua Bing Li Xue Za Zhi, Jun 2015
Immunohistochemical study showed that the tumor cells were positive for CD31, ERG, FLI-1, CD34, factor VIII and CKpan to different extents.
microRNA and Bone Cancer.
Review
Nugent, Dublin, Ireland. In Adv Exp Med Biol, 2014
The EWS-FLI1 fusion protein produced in Ewing sarcoma has been shown to induce changes in miRNA expression.
Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?
Review
Sorensen et al., Vancouver, Canada. In Crit Rev Oncog, 2014
Since the discovery of the pathognomonic EWS-FLI1 fusion gene more than 20 years ago, much about the molecular and cellular biology of ES pathogenesis has been learned.
EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma.
Review
Alonso et al., Madrid, Spain. In Front Oncol, 2014
Ewing sarcoma driving mutation, EWS-FLI1, which results from a chromosomal translocation, encodes an aberrant transcription factor.
ChIP-ping away at EWS/ETS transcription networks.
Impact
Denny, Los Angeles, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Riggi and colleagues use a genomic approach to define two distinct molecular mechanisms through which the chimeric EWS/FLI1 oncoprotein regulates target genes in Ewing sarcoma, expanding a framework upon which to model the target gene network and test strategies for antagonizing growth of this tumor.
Targeting the EWSR1-FLI1 oncogene-induced protein kinase PKC-β abolishes ewing sarcoma growth.
GeneRIF
Tirode et al., Paris, France. In Cancer Res, 2012
We found that transcriptional activation of PRKCB was directly regulated by the chimeric fusion oncogene EWSR1-FLI1 that drivesewing sarcoma growth.
Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration.
GeneRIF
McCulloch et al., Toronto, Canada. In Faseb J, 2012
FliI regulates cell migration through its localization to focal adhesions and its ability to cap actin filaments, which collectively affect focal adhesion maturation.
FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer.
GeneRIF
Teixeira et al., Porto, Portugal. In Genes Chromosomes Cancer, 2012
FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer and that intratumor genetic heterogeneity of ETS rearrangements can occasionally be found in index primary tumors.
Utility of immunohistochemical staining with FLI1, D2-40, CD31, and CD34 in the diagnosis of acquired immunodeficiency syndrome-related and non-acquired immunodeficiency syndrome-related Kaposi sarcoma.
GeneRIF
Cates et al., Nashville, United States. In Arch Pathol Lab Med, 2012
Data show there are no differences in the distribution of immunohistochemical reactivity for CD31, CD34, D2-40, or FLI1 between AIDS-related and non-AIDS-related Kaposi sarcoma (KS) or between nodular- and patch/plaque-stage KS.
Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription.
GeneRIF
Davis et al., Chapel Hill, United States. In Genome Res, 2012
EWS-FLI chimera acquired chromatin-altering activity, leading to mistargeting, chromatin disruption, and ultimately, transcriptional dysregulation.
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