High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
Efficient extravasation of tumor-repopulating cells depends on cell deformability.
Wuhan, China. In Sci Rep, Dec 2015
Here we show that when injected into the yolk of a 2 day-post-fertilization (dpf) embryo of Tg (fli1:EGFP or kdrl:mCherry) zebrafish, TRCs are much more efficient in surviving and growing at various secondary sites to generate micrometastasis and metastatic colonization than control melanoma cells that are grown on rigid plastic.
The Molecular Taxonomy of Primary Prostate Cancer.
In Cell, Dec 2015
Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1).
microRNA and Bone Cancer.
Dublin, Ireland. In Adv Exp Med Biol, 2014
The EWS-FLI1 fusion protein produced in Ewing sarcoma has been shown to induce changes in miRNA expression.
ChIP-ping away at EWS/ETS transcription networks.
Los Angeles, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Riggi and colleagues use a genomic approach to define two distinct molecular mechanisms through which the chimeric EWS/FLI1 oncoprotein regulates target genes in Ewing sarcoma, expanding a framework upon which to model the target gene network and test strategies for antagonizing growth of this tumor.