Genetics of ischemic stroke: An Indian scenario.
New Delhi, India. In Neurol India, Jan 2016
Combined linkage/association studies have demonstrated that genes encoding phosphodiesterase 4D (PDE4D) and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) confer risk for stroke.
Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients.
Boston, United States. In Crit Care Med, Dec 2015
Individually, ALOX12, PTGS2, PTGES, PTGDS, ALOX5AP, LTA4H, FPR2, PTGER2, LTB4R, HPGD, PTGR1, and CYP4F3 were expressed differentially over 28 days posttrauma between patients with uncomplicated and complicated recoveries (p < 0.05).
Recent advances for FLAP inhibitors.
Mölndal, Sweden. In Bioorg Med Chem Lett, Aug 2015
A number of FLAP inhibitors have been progressed to clinical trials for respiratory and other inflammatory indications but so far no drug has reached the market.
The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis.
Ostrava, Czech Republic. In Bmc Cardiovasc Disord, 2014
Using real time polymerase chain reaction and melting-curve analysis, we detected 13 single-nucleotide polymorphisms in 11 candidate genes - rs1803274 (BCHE gene), rs529038 (ROS1), rs1050450 (GPX1), rs1800849 (UCP3), rs17216473 (ALOX5AP), rs7412, rs429358 (ApoE), rs2228570 (VDR), rs7041, rs4588 (GC), rs1799986 (LRP1) and rs2228671 (LDLR).
Genetics of ischaemic stroke.
München, Germany. In Lancet Neurol, 2007
Genome-wide linkage studies in extended pedigrees from Iceland led to the identification of PDE4D and ALOX5AP.