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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cadherin, EGF LAG seven-pass G-type receptor 2

Flamingo, Celsr2, Epidermal growth factor-like, Celsr3
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Epidermal Growth Factor, Frizzled, V1a, HAD
Papers on Flamingo
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
New
Sun et al., Shanghai, China. In Oncotarget, Jan 2016
UNASSIGNED: Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3), an extracellular matrix (ECM) protein associated with vascular morphogenesis and remodeling, is commonly upregulated in multiple types of human cancers and correlates with tumor progression.
Metals and trace elements in feathers: A geochemical approach to avoid misinterpretation of analytical responses.
New
Dinelli et al., Ravenna, Italy. In Sci Total Environ, Jan 2016
We analysed 58 element concentrations in feathers of wild Eurasian Greater Flamingo Phoenicopterus roseus fledglings, from 4 colonies in Western Europe (Spain, France, Sardinia, and North-eastern Italy) and one group of adults from zoo.
Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.
New
Valladares-Salgado et al., Houston, United States. In Sci Rep, Dec 2015
Genome-wide significant signals were observed in or near CELSR2, ZNF259/APOA5, KANK2/DOCK6 and NCAN/MAU2 for total cholesterol, LPL, ABCA1, ZNF259/APOA5, LIPC and CETP for HDL cholesterol, CELSR2, APOB and NCAN/MAU2 for LDL cholesterol, and GCKR, TRIB1, ZNF259/APOA5 and NCAN/MAU2 for triglycerides.
Phase 1 Study of Monotherapy with KHK2866, an Anti-Heparin-Binding Epidermal Growth Factor-Like Growth Factor Monoclonal Antibody, in Patients with Advanced Cancer.
New
Camacho et al., San Antonio, United States. In Target Oncol, Nov 2015
BACKGROUND: KHK2866 is a recombinant, humanized, non-fucosylated, monoclonal antibody directed at heparin-binding epidermal growth factor-like growth factor (HB-EGF).
The impact of low-frequency and rare variants on lipid levels.
New
Impact
ENGAGE Consortium et al., Helsinki, Finland. In Nat Genet, Jun 2015
In six loci, SNPs with established function in lipid genetics (CELSR2, GCKR, LIPC and APOE) or candidate missense mutations with predicted damaging function (CD300LG and TM6SF2) explained the locus associations.
Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease.
Review
New
Petersen et al., Århus, Denmark. In Curr Atheroscler Rep, Apr 2015
This locus harbors four candidate genes, CELSR2, PSRC1, MYBPHL, and SORT1.
Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke.
Chen et al., Nanning, China. In Int J Clin Exp Pathol, 2014
Our study was to assess the association of CELSR2-PSRC1-SORT1 rs599839, rs464218 and rs6698443 SNPs and serum lipid levels and the risk of CAD and IS.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Review
Impact
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 2014
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
Connecting SNPs in Diabetes: A Spatial Analysis of Meta-GWAS Loci.
Review
O'Sullivan et al., Auckland, New Zealand. In Front Endocrinol (lausanne), 2014
Our findings include a three-way functional-spatial connection between the TM6SF2, CTRB1-BCAR1, and CELSR2-PSRC1 loci (rs201189528, rs7202844, and rs7202844, respectively) connected through the KCNIP3 and BCAR1/BCAR3 loci, respectively.
Protocol for a randomised controlled trial of fetal scalp blood lactate measurement to reduce caesarean sections during labour: the Flamingo trial [ACTRN12611000172909].
Flamingo Study Group et al., Melbourne, Australia. In Bmc Pregnancy Childbirth, 2014
BACKGROUND: The rate of caesarean sections around the world is rising each year, reaching epidemic proportions.
Wnt-signaling and planar cell polarity genes regulate axon guidance along the anteroposterior axis in C. elegans.
Review
Ackley, Lawrence, United States. In Dev Neurobiol, 2014
The core set of PCP genes include members of the conserved Wnt-signaling pathway, such as Frizzled and Disheveled, but also the cadherin-domain protein Flamingo.
Protocol for physical assessment in patients with fibromyalgia syndrome.
Review
Vosgerau et al., In Rev Bras Reumatol, 2014
RESULTS: A variety of tests was found; the following, by number of citations, stood out: Body Mass Index (BMI) and bioimpedance; 6-minute walk; handgrip strength (dynamometer, 1RM [Repetition Maximum]); Sit and reach and Shoulder flexibility; Foot Up and Go, and Flamingo balance.
A network of cadherin-mediated interactions polarizes growth cones to determine targeting specificity.
Impact
Clandinin et al., Stanford, United States. In Cell, 2013
We demonstrate that the classical cadherin, N-cadherin, and an atypical cadherin, Flamingo, act redundantly to instruct the targeting choices made by every photoreceptor axon.
Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
GeneRIF
Lawrence et al., New York City, United States. In Development, 2012
We deduce that each cell has a mechanism to estimate and compare the numbers of asymmetric bridges, made between Stan and Stan plus Fz, that link it with its neighbouring cells.
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche.
Impact
GeneRIF
Li et al., Kansas City, United States. In Cell, 2012
Study shows Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain quiescent long-term hematopoietic stem cells.
Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadherin Flamingo.
GeneRIF
Uemura et al., Kyoto, Japan. In Genes Cells, 2012
In the SMC3 mutant cells, Fmi appeared to be upregulated by a posttranscriptional mechanism(s), and this elevation of Fmi was at least one cause of the planar cell polarity defect.
The core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryo.
GeneRIF
Whitington et al., Melbourne, Australia. In Dev Biol, 2011
The planar cell polarity gene prickle interacts with flamingo in regulating sensory axon advance at a key choice point - the transition between the peripheral nervous system and the central nervous system.
The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons.
GeneRIF
Uemura et al., Kyoto, Japan. In Genes Dev, 2011
Espinas (Esn), binds to an intracellular juxtamembrane domain of Flamingo (Fmi), and that this Fmi-Esn interplay elicits repulsion between dendritic branches of Drosophila sensory neurons
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Impact
Nykjaer et al., Århus, Denmark. In Cell Metab, 2010
This locus covers three genes: SORT1, CELSR2, and PSRC1.
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