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FK506 binding protein 5

FKBP51, FKBP5
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: FKBP52, Hsp90, CAN, HAD, V1a
Papers using FKBP51 antibodies
A polycomb repression signature in metastatic prostate cancer predicts cancer outcome.
Supplier
Randau Lennart, In PLoS ONE, 2006
... Santa Cruz, CA.), FASN (fatty acid synthase, mouse monoclonal, BD Transduction Labs, Franklin Lakes, NJ), FKBP5 (FK506 binding protein 5, mouse monoclonal, BD Transduction Labs), AR (mouse monoclonal-AR441, Lab Vision, Fremont, CA), GARS (glycyl-tRNA synthetase, rabbit polyclonal, Abcam, Cambridge, MA), WARS (tryptophanyl-tRNA ...
Papers on FKBP51
Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression.
New
Martín-Santos et al., Barcelona, Spain. In Int J Neuropsychopharmacol, Jan 2016
We genotyped several functional polymorphisms of interleukin-28 (IL28B), indoleamine 2,3-dioxygenase (IDO-1), serotonin receptor-1A (HTR1A), catechol-O-methyl transferase (COMT), glucocorticoid receptors (GCR1 and GCR2), brain-derived neurotrophic factor (BDNF) and FK506 binding protein 5 (FKBP5) genes.
The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells.
New
He et al., Lanzhou, China. In J Hazard Mater, Jan 2016
Here, we characterized p-nitrophenol binds to the FK1 domain of an AR positive regulator FKBP51 with micromolar affinity and structural analysis of FK1 domain in complex with p-nitrophenol revealed that p-nitrophenol occupies a hydrophobic FK1 pocket that is vital for AR activity enhancement.
What can HPA axis-linked genes tell us about anxiety disorders in adolescents?
New
Manfro et al., Porto Alegre, Brazil. In Trends Psychiatry Psychother, Dec 2015
We extracted DNA from saliva and genotyped polymorphisms in HPA-linked genes (FKBP5: rs3800373, rs9296158, rs1360780, rs9470080 and rs4713916; NR3C1: rs6198; CRHR1: rs878886; and SERPINA6: rs746530) with real time polymerase chain reaction (PCR).
HPA AXIS RELATED GENES AND RESPONSE TO PSYCHOLOGICAL THERAPIES: GENETICS AND EPIGENETICS.
New
Wong et al., London, United Kingdom. In Depress Anxiety, Dec 2015
Polymorphisms of FKBP5 and GR were analyzed for association with response to CBT.
Associations Between Self-Reported and Objectively Recorded Early Life Stress, FKBP5 Polymorphisms, and Depressive Symptoms in Midlife.
New
Räikkönen et al., Helsinki, Finland. In Biol Psychiatry, Dec 2015
BACKGROUND: FK506-binding protein 51 is involved in hypothalamic-pituitary-adrenal axis regulation.
Adipogenesis is under surveillance of Hsp90 and the high molecular weight Immunophilin FKBP51.
Review
New
Piwien-Pilipuk et al., Buenos Aires, Argentina. In Adipocyte, Oct 2015
It was not until recently that the first evidences of the role of heat shock protein (Hsp) 90 and high molecular weight immunophilin FKBP51 have been described in the process of adipocyte differentiation.
Stress-induced mechanisms in mental illness: A role for glucocorticoid signalling.
Review
New
Riva et al., London, United Kingdom. In J Steroid Biochem Mol Biol, Sep 2015
Indeed, exposure to chronic stress early in life as well as in adulthood has been shown to reduce the expression of glucocorticoid receptors (GR), also through epigenetic mechanisms, and to up-regulate the expression of the co-chaperone gene FKBP5, which restrains GR activity by limiting the translocation of the receptor complex to the nucleus.
Pharmacogenetics of major depressive disorder: top genes and pathways toward clinical applications.
Review
New
Serretti et al., Bologna, Italy. In Curr Psychiatry Rep, Jul 2015
The best single genes are SLC6A4, HTR2A, BDNF, GNB3, FKBP5, ABCB1, and cytochrome P450 genes (CYP2D6 and CYP2C19).
Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling.
Review
New
Ward et al., Australia. In Clin Biochem Rev, May 2015
The steroid receptor-associated immunophilins FKBP51, FKBP52, CyP40 and PP5 have specific roles in steroid receptor function that impact steroid hormone-binding affinity, nucleocytoplasmic shuttling and transcriptional activation of target genes in a tissue-specific manner.
The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease.
Review
New
Dickey et al., Tampa, United States. In J Neurochem, Apr 2015
PPIases, including Pin1, FK506-binding protein (FKBP) 52, FKBP51, and FKBP12, have been shown to interact with and regulate tau biology.
FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells.
GeneRIF
Barth et al., Ulm, Germany. In Cell Microbiol, 2012
FKBP51 is identified as a novel interaction partner of the Clostridium botulinum C2 toxin and is directly involved in the membrane translocation of the toxin to the cytoplasm.
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51.
Review
GeneRIF
Galigniana et al., Buenos Aires, Argentina. In J Neurochem, 2012
The polymorphisms of FKBP51 is releated to stress-related disorders.
Functional changes in myeloid-derived suppressor cells (MDSCs) during tumor growth: FKBP51 contributes to the regulation of the immunosuppressive function of MDSCs.
GeneRIF
Kang et al., Seoul, South Korea. In J Immunol, 2012
FKBP51 contributes to the regulation of the suppressive function of MDSCs by increasing inducible NO synthase, arginase-1, and reactive oxygen species levels and enhancing NF-kappaB activity.
Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5.
GeneRIF
Lee et al., Baltimore, United States. In Biochem Biophys Res Commun, 2012
Dnmt1 is involved in the observed epigenetic alterations of Fkbp5.
FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer.
GeneRIF
Wang et al., Rochester, United States. In Plos One, 2011
FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer.
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.
Impact
Wu et al., Los Angeles, United States. In Cancer Cell, 2011
Conditional deletion of Ar in the epithelium promotes the proliferation of Pten null cancer cells, at least in part, by downregulating the androgen-responsive gene Fkbp5 and preventing PHLPP-mediated AKT inhibition.
Neuropsin cleaves EphB2 in the amygdala to control anxiety.
Impact
Pawlak et al., Leicester, United Kingdom. In Nature, 2011
Here we show in mice that the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynamics of the EphB2-NMDA-receptor interaction, the expression of Fkbp5 and anxiety-like behaviour.
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.
Impact
GeneRIF
Wang et al., Rochester, United States. In Cancer Cell, 2009
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.
A molecular link between AKT regulation and chemotherapeutic response.
Impact
Manning et al., Boston, United States. In Cancer Cell, 2009
In this issue of Cancer Cell, Pei et al. show that FKBP51 negatively regulates AKT through the phosphatase PHLPP.
Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
Impact
GeneRIF
Ressler et al., Atlanta, United States. In Jama, 2008
Genetic variation in the FKBP5 gene may alter sensitization of the stress-response pathway during development, placing those individuals who have had significant child abuse at significant risk for PTSD.
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