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Flt3 interacting zinc finger protein 1

Fiz1, Flt3 interacting zinc finger protein
This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FLT3, CRX, ROD, Rhodopsin, CAN
Papers on Fiz1
Dissection of a novel autocrine signaling pathway via quantitative secretome and interactome mapping.
Trinkle-Mulcahy et al., Ottawa, Canada. In J Proteome Res, 2014
We show here that the signal transducer/transcription factor FIZ1 (Flt3 interacting zinc finger protein-1) is a previously unknown player in this regulatory axis, promoting an increase in proliferation of HaCaT human immortalized keratinocytes that is driven by more rapid G1/S progression and mediated by activation of the MAP/ERK kinase pathway.
Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas.
GeneRIF
Hiai et al., Kyoto, Japan. In J Leukoc Biol, 2010
FLT3 and CD43 signaling pathways involve STAT5A via Fiz1 and Hipk2 in B lymphoblastic lymphomas.
Temporal ChIP-on-Chip of RNA-Polymerase-II to detect novel gene activation events during photoreceptor maturation.
Mitton et al., United States. In Mol Vis, 2009
FLT-3 Interacting Zinc-finger-1 (FIZ1), a zinc-finger protein that associates with active promoter complexes of photoreceptor-specific genes, provided an additional ChIP marker to highlight genes activated in the mature neural retina.
FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
GeneRIF
Mitton et al., United States. In Bmc Mol Biol, 2007
Fiz1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro.
GeneRIF
Mitton et al., United States. In Exp Eye Res, 2007
Activators of the Rhodopsin gene are present before activation of the gene. FIZ1 expression rises at this time and it can synergize with NRL and CRX at the Rho and PDE6B promoters. FIZ1 may syncronize the onset of maturation related gene expression.
Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiation.
Ash et al., Oklahoma City, United States. In Invest Ophthalmol Vis Sci, 2005
LIF also reduced the expression of Crx, Nrl, and Nr2e3, and upregulated the expression of transcription inhibitors Baf and Fiz1.
Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells.
GeneRIF
Heinrich et al., Portland, United States. In Blood, 2005
Addition of potent FLT3 inhibitors such as SU11248 to acute myeloid leukemia chemotherapy regimens could result in improved treatment results.
Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor.
GeneRIF
Swaroop et al., Ann Arbor, United States. In Hum Mol Genet, 2003
Homologous to mouse and bovine Fiz1 (flt-3 interacting zinc finger). Interacts with NRL (neural retina leucine zipper). Antibody detects protein in human, mouse, bovine retina. Possible role for Fiz1 as a transcriptional repressor.
Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3.
Rohrschneider et al., Seattle, United States. In J Biol Chem, 1999
In addition to several SH2 domain-containing proteins, we have isolated a novel Flt3 interacting zinc finger protein (Fiz1) with 11 C(2)H(2)-type zinc fingers.
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