GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Interleukin 24
FISP, mda-7, IL-24, interleukin-24
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
IL-10, CAN, P28, V1a, IL-19
Papers on
FISP
CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth.
New
Hangzhou, China. In Oncotarget, Jan 2016
Ad.4N1 was further engineered to harbor a gene encoding melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24), forming Ad.4N1-IL24, which replicated dramatically faster than Ad.4N1, and elicited significantly enhanced antileukemia effect in vitro and in a HL60/Luc xenograft mouse model.
ILs-3, 6 and 11 increase, but ILs-10 and 24 decrease stemness of human prostate cancer cells in vitro.
New
Zhengzhou, China. In Oncotarget, Jan 2016
In line with the above findings, treatment with either IL-3 or IL-6 or IL-11 decreased the chemosensitivity to docetaxel while treatment with either IL-10 or IL-24 increased the sensitivity of docetaxel chemotherapy.
Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways.
New
München, Germany. In Mucosal Immunol, Dec 2015
Furthermore, the IL-4-dependent induction of IL-24 observed in rhinitis patients was downregulated by IFN-γ, and therefore IL-24 represents a potential biomarker of allergic inflammation and a Th2 polarized condition of the epithelium.Mucosal Immunology advance online publication, 18 November 2015; doi:10.1038/mi.2015.110.
Differential expression of inflammation-related genes in IL-4 transgenic mice before and after the onset of atopic dermatitis skin lesions.
New
Chicago, United States. In Mol Cell Probes, Dec 2015
Particularly, CXCL5, IL-1β, IL-24, IL-6, oncostatin M, PTGS2, FPR1 and REG3γ are up-regulated several hundred-fold.
Construction of expressing vectors including melanoma differentiation-associated gene-7 (mda-7) fused with the RGD sequences for better tumor targeting.
New
Shīrāz, Iran. In Iran J Basic Med Sci, Aug 2015
OBJECTIVES: Up to now, many researches have been performed to improve the antitumoral effect of melanoma differentiation-associated gene-7 (mda-7) protein.
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.
Impact
Brisbane, Australia. In Nat Med, 2014
We demonstrate that multiple inflammatory cytokines elevated in diabetic pancreatic islets induce beta cell oxidative and ER stress, with interleukin-23 (IL-23), IL-24 and IL-33 being the most potent.
The IL-20 subfamily of cytokines--from host defence to tissue homeostasis.
Review
Impact
San Francisco, United States. In Nat Rev Immunol, 2014
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Review
Budapest, Hungary. In Mediators Inflamm, 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
Expression and effect of serum interleukin-24 level on bone marrow mononuclear cells in children with acute leukemia.
Shenzhen, China. In Genet Mol Res, 2014
To investigate the expression of interleukin-24 (IL-24) in the children with acute leukemia (AL) and its effect on the apoptosis of bone marrow mononuclear cells (BMMNCs) in vitro.
IL-10 function, regulation, and in bacterial keratitis.
Review
Detroit, United States. In J Ocul Pharmacol Ther, 2014
The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation.
MDA-7/IL-24: multifunctional cancer killing cytokine.
Review
Richmond, United States. In Adv Exp Med Biol, 2013
First identified almost two decades ago as a novel gene differentially expressed in human melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great potential as an anti-cancer gene.
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.
Impact
Köln, Germany. In Immunity, 2013
Here we report that the development of psoriasis-like skin inflammation in mice with epidermis-specific inhibition of the transcription factor NF-κB was triggered by TNF receptor 1 (TNFR1)-dependent upregulation of interleukin-24 (IL-24) and activation of signal transducer and activator of transcription 3 (STAT3) signaling in keratinocytes.
Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus.
Impact
Bethesda, United States. In Nat Immunol, 2013
Interleukin 19 (IL-19), IL-20 and IL-24 signal through type I and type II IL-20 receptors and are associated with inflammatory skin diseases such as psoriasis and atopic dermatitis.
Enhanced apoptosis-inducing function of MDA-7/IL-24 RGD mutant via the increased adhesion to tumor cells.
GeneRIF
Xuzhou, China. In J Interferon Cytokine Res, 2012
RGD-IL-24 can enhance the apoptosis of tumor cells and may provide a promising drug in tumor therapy.
Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects.
GeneRIF
Chiba, Japan. In Cell Immunol, 2012
Secretory mIL-24 did not induce the expression of the IL-6, TNF-alpha or IFN-gamma gene in spleen cells
Expression of interleukin-24 and its receptor in human pancreatic myofibroblasts.
GeneRIF
Ōtsu, Japan. In Int J Mol Med, 2011
IL-24 is expressed in chronic pancreatitis tissue, and may play a role in the pathophysiology of chronic pancreatitis via autocrine pathways.
Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes.
Review
Richmond, United States. In Adv Cancer Res, 2011
Based on these considerations, a novel class of cancer destroying adenoviruses have been produced, cancer terminator viruses (CTVs), in which cancer-specific replication is controlled by the progression-elevated gene-3 promoter and replicating viruses produce a second transgene encoding an apoptosis-inducing and immunomodulatory cytokine, either melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) or interferon-γ.
Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.
GeneRIF
Loma Linda, United States. In Cytokine, 2011
regulation suggests that alternative splicing of mda-7/IL-24 is under tight control in the cell, and can be modified under various cellular conditions, such as DNA damage
Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.
GeneRIF
Cape Town, South Africa. In Plos One, 2010
Data show that mda-7/IL-24 activation leads to upregulation of growth arrest and DNA damage inducible (GADD) 45 alpha and gamma and JNK activation.
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Review
Impact
San Francisco, United States. In Annu Rev Immunol, 2010
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29.
