Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways.
München, Germany. In Mucosal Immunol, Dec 2015
Furthermore, the IL-4-dependent induction of IL-24 observed in rhinitis patients was downregulated by IFN-γ, and therefore IL-24 represents a potential biomarker of allergic inflammation and a Th2 polarized condition of the epithelium.Mucosal Immunology advance online publication, 18 November 2015; doi:10.1038/mi.2015.110.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Budapest, Hungary. In Mediators Inflamm, 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
IL-10 function, regulation, and in bacterial keratitis.
Detroit, United States. In J Ocul Pharmacol Ther, 2014
The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation.
MDA-7/IL-24: multifunctional cancer killing cytokine.
Richmond, United States. In Adv Exp Med Biol, 2013
First identified almost two decades ago as a novel gene differentially expressed in human melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great potential as an anti-cancer gene.
Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes.
Richmond, United States. In Adv Cancer Res, 2011
Based on these considerations, a novel class of cancer destroying adenoviruses have been produced, cancer terminator viruses (CTVs), in which cancer-specific replication is controlled by the progression-elevated gene-3 promoter and replicating viruses produce a second transgene encoding an apoptosis-inducing and immunomodulatory cytokine, either melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) or interferon-γ.
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
San Francisco, United States. In Annu Rev Immunol, 2010
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29.