Toulouse, France. In Semin Cell Dev Biol, 2010
DRP1 and FIS1 control mitochondrial outer membrane fission and Mitofusins its fusion.
Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia.
Praha, Czech Republic. In Int J Biochem Cell Biol, 2009
Here we overview the main properties and regulation of pro-fusion and pro-fission mitodynamins, i.e. dynamins-related GTPases responsible for mitochondrial shape-forming, such as pro-fusion mitofusins MFN1, MFN2, and the inner membrane-residing long OPA1 isoforms, and pro-fission mitodynamins FIS1, MFF, and DRP1 multimers required for scission.
Shared components of mitochondrial and peroxisomal division.
Marburg an der Lahn, Germany. In Biochim Biophys Acta, 2006
Recent studies have led to the surprising finding that both organelles share components of their division machinery, namely the dynamin-related protein DLP1/Drp1 and hFis1, which recruits DLP1/Drp1 to the organelle membranes.