Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes.
Gwalior, India. In Gene, Mar 2016
MATERIALS AND METHODS: Methylation specific PCR for seven tumour associated genes, viz., MASPIN, 14-3-3 sigma gene, THBS1, FLNC, HLTF, COX-2 and SOCS1, was performed in 50 gallbladder cancer (GBC), 30 gall stone diseases (GSD) and their respective adjacent control tissues.
Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats.
United States. In Am J Physiol Regul Integr Comp Physiol, Feb 2016
The most important results were that in isolated muscles, CR versus AL resulted in: 1) greater insulin-stimulated glucose uptake; 2) that was accompanied by significantly increased insulin-mediated activation of Akt2 as indicated by greater phosphorylation on both Thr(309) and Ser(474) along with greater Akt2 activity; 3) concomitant with enhanced phosphorylation of several Akt substrates, including Akt Substrate of 160 kDa on Thr(642) and Ser(588), filamin C on Ser(2213) and proline-rich Akt substrate of 40 kDa on Thr(246), but not TBC1D1 on Thr(596); and 4) each of the CR-effects was eliminated by MK-2206.
Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue.
Helsinki, Finland. In Eur Urol, Nov 2015
Seven genes, FLNC, MSRB3, PARVA, PCDH7, PRNP, RAB34, and SORBS1, showed an inverse association to their predicted miRNA, and were identified to significantly correlate with biochemical recurrence free survival in PCa patients.
Biomechanical characterization of myofibrillar myopathies.
Erlangen, Germany. In Cell Biol Int, Apr 2015
Most MFMs are caused by mutations in genes encoding desmin, plectin, VCP, filamin C, BAG3, FHL-1, αB-crystallin, DNAJB6, myotilin, and ZASP.
Tokyo, Japan. In Rinsho Shinkeigaku, 2012
Several causative genes have been identified such as DES, CRYAB, MYOT, ZASP, BAG3, FLNC, DNAJB6, FHL1, TTN, and VCP.
Aachen, Germany. In Handb Clin Neurol, 2012
The causative genes encode mainly sarcomeric Z-disk(-related) proteins: desmin, αB-crystallin, myotilin, Z-band alternatively spliced PDZ motif containing protein (ZASP), filamin C and the antiapoptotic BCL2-associated athanogene 3 (Bag3).
Rochester, United States. In Handb Clin Neurol, 2010
To date, all MFM mutations have appeared in Z-disk-associated proteins: namely, desmin, αB-crystallin, myotilin, ZASP, filamin C, and Bag3.