Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
In The Journal of Cell Biology, 2003
... (EMD), histones, α1-integrin, paxillin (Millipore), PAI-1, Smad3 (Abcam), FAK, zonula occludens-1, phospho-FAK (Invitrogen), E-cadherin and filamin A (clone 5/ABP280; BD), HA.11 (clone 16B12; Covance), and CapZ (AbD Serotec).
Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours.
Rozzano, Italy. In Endocr Relat Cancer, Feb 2016
Since it has been demonstrated that Filamin A (FLNA) is involved in mediating GPCR expression, membrane anchoring and signalling, we investigated the role of this cytoskeleton protein in SST2 expression and signalling, angiogenesis, cell adhesion and cell migration in human P-NETs and in QGP1 cell line.
Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling, and Importance of Interacting Proteins.
Bethesda, United States. In Prog Mol Biol Transl Sci, 2014
These processes are impacted by its interactions with several proteins in addition to signaling molecules per se (i.e., G-proteins, protein kinases, inositol phosphates, etc.) and include small molecular weight G-proteins (Sar1, Rabs, ARF, P24A, RAMPs, filamin A, 14-3-3 proteins, calmodulin, and caveolin-1).
A stem cell-based approach to cartilage repair.
San Diego, United States. In Science, 2012
Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program.