Role of copper in regression of cardiac hypertrophy.
Chengdu, China. In Pharmacol Ther, Apr 2015
Copper is also required for hypoxia-inducible factor-1 (HIF-1) transcriptional activity, acting on the interaction between HIF-1 and the hypoxia responsible element and the formation of HIF-1 transcriptional complex by inhibiting the factor inhibiting HIF-1.
First phase insulin secretion and type 2 diabetes.
Sydney, Australia. In Curr Mol Med, 2013
These include, among others, hypoxia inducible factor 1α, von Hippel-Lindau, factor inhibiting HIF, nicotinamide phospho-ribosyl-transferase, and the sirtuin family.
Regulation of erythropoietin production.
Lübeck, Germany. In J Physiol, 2011
Three HIF-α prolyl hydroxylases (PHD-1, -2 and -3) initiate proteasomal degradation of HIF-α, while an asparaginyl hydroxylase ('factor inhibiting HIF-1', FIH-1) inhibits the transactivation potential.
Proline hydroxylation and gene expression.
Boston, United States. In Annu Rev Biochem, 2004
In addition, the HIFalpha transcriptional activation function is modulated further by asparagine hydroxylation by FIH (factor-inhibiting HIF), which affects recruitment of the coactivators p300 and CBP.