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Fibulin 5

fibulin-5, FBLN5
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: elastin, fibrillin-1, AGE, CAN, HAD
Papers on fibulin-5
Quantitative Tissue Proteomics Analysis Reveals Versican as Potential Biomarker for Early-Stage Hepatocellular Carcinoma.
Sitek et al., Bochum, Germany. In J Proteome Res, Feb 2016
We present the overexpression of ATP-dependent RNA helicase (DDX39), Fibulin-5 (FBLN5), myristoylated alanine-rich C-kinase substrate (MARCKS), and Serpin H1 (SERPINH1) in HCC for the first time.
Co-expression of fibulin-5 and VEGF165 increases long-term patency of synthetic vascular grafts seeded with autologous endothelial cells.
Flugelman et al., Haifa, Israel. In Gene Ther, Jan 2016
We tested the hypothesis that induced expression by the seeded EC, of vascular endothelial growth factor165 (VEGF165) and of fibulin-5, an extracellular matrix glycoprotein that has a crucial role in elastin fiber organization and increase EC adherence to surfaces, may improve long-term graft patency.
Clinically detectable drusen domains in fibulin-5-associated age-related macular degeneration (AMD) : Drusen subdomains in fibulin-5 AMD.
Russell et al., Ankara, Turkey. In Int Ophthalmol, Jan 2016
UNASSIGNED: To evaluate whether drusen of subjects with fibulin-5 mutation-associated age-related macular degeneration (AMD) have clinically demonstrable drusen domains as evidenced by differences between color and fluorescein angiographic profiles.
Fibulin-5 is upregulated in decidualized human endometrial stromal cells and promotes primary human extravillous trophoblast outgrowth.
Dimitriadis et al., Australia. In Placenta, Dec 2015
Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrophoblasts.
Genome-wide association study on reproductive traits in Jinghai Yellow Chicken.
Shi et al., Yangzhou, China. In Anim Reprod Sci, Dec 2015
These SNPs were located in close proximity to or within the sequence of the five candidate genes, including FAM184B, TTL, RGS1, FBLN5 and PCNX.
Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner.
Mariman et al., Maastricht, Netherlands. In Genes Nutr, Nov 2015
Regression analyses provided us with six significant SNPs associated with the WMS in males: 3 SNPs in the POSTN gene and a SNP in the LAMB1, COL23A1, and FBLN5 genes.
[Diverse functions of fibulin-5 in tumors].
Cai et al., In Mol Biol (mosk), 2014
As a member of matricellular glycoprotein, fibulin-5 is expressed in elastin-rich tissues and organizes the matrix structures by interacting with many extracellular proteins.
Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies.
Yanagisawa et al., Dallas, United States. In Matrix Biol, 2014
Despite manifestation of systemic elastic fiber defects in all elastogenic tissues, fibulin-5 null (Fbln5(-/-)) mice have a normal lifespan.
Cutis laxa: intersection of elastic fiber biogenesis, TGFβ signaling, the secretory pathway and metabolism.
Davis et al., Pittsburgh, United States. In Matrix Biol, 2014
Elastin, fibulin-4, fibulin-5 and latent transforming growth factor-β-binding protein 4 are secreted proteins which form elastic fibers and are involved in the sequestration and subsequent activation of transforming growth factor-β (TGFβ).
The various Charcot-Marie-Tooth diseases.
Funalot et al., Limoges, France. In Curr Opin Neurol, 2013
RECENT FINDINGS: To date, numerous genes are implicated in CMT, and new genes have recently been found to be associated with this neuropathy (INF2, FBLN5, etc.).
miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5.
Chegini et al., Gainesville, United States. In Endocr Relat Cancer, 2012
Altered expression of miR-200c may have a significant impact on the outcome of leiomyomas growth, maintenance of their mesenchymal and fibrotic characteristics, and possibly their associated symptoms.
Effect of mechanical stretch on the expressions of elastin, LOX and Fibulin-5 in rat BMSCs with ligament fibroblasts co-culture.
Xi et al., Zhengzhou, China. In Mol Biol Rep, 2012
These results suggest that in an indirect co-culture system, pelvic ligament fibroblasts with mechanical stretch stimulation can promote bone mesenchymal stem cell differentiation, reflecting in the increased expression of elastin, LOX, and Fibulin-5.
Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.
Tkachuk et al., Moscow, Russia. In Biochem J, 2012
suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility
Fibulin-5 mutations link inherited neuropathies, age-related macular degeneration and hyperelastic skin.
Guelly et al., Graz, Austria. In Brain, 2011
This study identifies fibulin-5 as a gene involved in Charcot-Marie-Tooth neuropathies and reveals heterozygous fibulin-5 mutations in 2% of our patients with age-related macular degeneration and hyperelastic skin.
Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.
Yanagisawa et al., Dallas, United States. In J Clin Invest, 2011
MMP9 and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans
[Connective tissue and prolapse genesis].
Tremollieres, Toulouse, France. In Gynecol Obstet Fertil, 2010
Mice with null mutation in the gene encoding lysyl oxidase-like 1 (LOXL1) or fibulin-5, demonstrate signs of elastinopathy including the development of a POP in the postpartum.
Missense variations in the fibulin 5 gene and age-related macular degeneration.
Sheffield et al., Iowa City, United States. In N Engl J Med, 2004
Missense mutations in the fibulin 5 gene were found in 1.7 percent of patients with AMD.
Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.
Li et al., Boston, United States. In Nat Genet, 2004
Distinct from the prototypic lysyl oxidase (LOX), LOXL1 localizes specifically to sites of elastogenesis and interacts with fibulin-5.
Fibulin-5/DANCE is essential for elastogenesis in vivo.
Chien et al., San Diego, United States. In Nature, 2002
Here we report that fibulin-5 (also known as DANCE), a recently discovered integrin ligand, is an essential determinant of elastic fibre organization.
Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo.
Olson et al., Dallas, United States. In Nature, 2002
Fibulin-5 is a calcium-dependent, elastin-binding protein that localizes to the surface of elastic fibres in vivo.
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