gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Fibronectin 1

fibronectin
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, Actin, HAD, ACID
Papers using fibronectin antibodies
MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets.
Supplier
Tjwa Marc, In PLoS ONE, 2009
... Cor.At® cardiomyocytes each were then seeded onto Fibronectin-coated 10 cm dishes (Becton Dickinson, Heidelberg, Germany) in IMDM ...
Detection of novel 3′ untranslated region extensions with 3′ expression microarrays
Supplier
Muro Andrés Fernando et al., In Nucleic Acids Research, 2009
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Akt cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects
Supplier
Cho Jae Youl et al., In Mediators of Inflammation, 2009
... Fibronectin was obtained from BD Biosciences (San Diego, CA) ...
An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden in a pre-clinical model of ovarian cancer metastasis.
Supplier
Lengyel E et al., In Oncogene, 2009
... Anti FAK and paxillin antibodies, growth factor reduced matrigel and human fibronectin were from BD Biosciences (San Jose, CA), phospho-FAK ...
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
Supplier
Salh Baljinder et al., In BMC Immunology, 2008
... Anti-FoxP3 antibody was obtained from eBiosciences (San Diego, CA); anti-fibronectin antibody from Abcam (Cambridge, MA); anti-alpha 5 integrin ...
more suppliers
Papers on fibronectin
Biomimetic modified clinical-grade POSS-PCU nanocomposite polymer for bypass graft applications: A preliminary assessment of endothelial cell adhesion and haemocompatibility.
New
Seifalian et al., Tehrān, Iran. In Mater Sci Eng C Mater Biol Appl, 31 Jan 2015
CONCLUSION: Poly-AA-g-POSS-PCU surfaces offer binding sites for the covalent bonding of collagen type I and other biomolecules such as fibronectin by exposure of RGD cell binding domains and growth factors using EDC cross-linking chemistry.
High-performance scaffolds on titanium surfaces: Osteoblast differentiation and mineralization promoted by a globular fibrinogen layer through cell-autonomous BMP signaling.
New
Udagawa et al., Shiojiri, Japan. In Mater Sci Eng C Mater Biol Appl, 31 Jan 2015
To develop new bioactive modification on titanium surfaces to achieve full osseointegration expeditiously, we used fibrinogen and fibronectin as bioactive scaffolds on the titanium plate, which are common extracellular matrix (ECM) proteins.
Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses.
New
Inoue et al., Ōsaka, Japan. In Protein Sci, 09 Jan 2015
UNLABELLED: ROBO1, fibronectin type-III domain (Fn)-containing protein, is a novel immunotherapeutic target for hepatocellular carcinoma in humans.
Fibronectin matrix assembly after spinal cord injury.
New
Lee et al., Miami, United States. In J Neurotrauma, 09 Jan 2015
UNLABELLED: After spinal cord injury (SCI), a fibrotic scar forms at the injury site that is best characterized by the accumulation of perivascular fibroblasts and deposition of the extracellular matrix protein fibronectin.
Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events.
Review
New
Sheetz et al., Singapore, Singapore. In Biophys J, 02 Jan 2015
UNLABELLED: In this review, we focus on the early events in the process of fibroblast spreading on fibronectin matrices of different rigidities.
Extracellular matrix assembly: a multiscale deconstruction.
New
Impact
Weaver et al., San Francisco, United States. In Nat Rev Mol Cell Biol, 31 Dec 2014
The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM.
Hepatic fibrogenesis and transforming growth factor/Smad signaling activation in rats chronically exposed to low doses of lead.
New
Sánchez et al., In J Appl Toxicol, 31 Dec 2014
Results showed increased laminin, collagen IV and fibronectin, located at the perisinusoidal space.
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
New
Impact
Nikolov et al., New York City, United States. In Science, Jul 2014
The differences result from different lengths of the linker connecting receptor domains fibronectin type III domain 4 (FN4) and FN5, which differs among DCC and neogenin splice variants, providing a basis for diverse signaling outcomes.
Rigidity sensing and adaptation through regulation of integrin types.
New
Impact
Roca-Cusachs et al., London, United Kingdom. In Nat Mater, Jun 2014
Cell binding to fibronectin through either α5β1 integrins (constitutively expressed) or αvβ6 integrins (selectively expressed in cancer and development) adapts force generation, actin flow and integrin recruitment to rigidities associated with healthy or malignant tissue, respectively.
Epithelial bridges maintain tissue integrity during collective cell migration.
New
Impact
Ladoux et al., Singapore, Singapore. In Nat Mater, Jan 2014
Here, we show that monolayers of human keratinocytes migrating along functionalized micropatterned surfaces comprising alternating strips of extracellular matrix (fibronectin) and non-adherent polymer form suspended multicellular bridges over the non-adherent areas.
Vitamin A Deficiency and Alterations in the Extracellular Matrix.
Review
New
Timoneda et al., Burjassot, Spain. In Nutrients, Dec 2013
Extracellular matrix proteins are among those whose synthesis is known to be modulated by vitamin A. Retinoic acid, the main biologically active form of vitamin A, influences the expression of collagens, laminins, entactin, fibronectin, elastin and proteoglycans, which are the major components of the extracellular matrix.
Roles for DSCAM and DSCAML1 in central nervous system development and disease.
Review
New
Montesinos, In Adv Neurobiol, Dec 2013
DSCAMs (Down syndrome cell adhesion molecules) are a group of immunoglobulin-like transmembrane proteins that contain fibronectin III domains.
The L1 family of cell adhesion molecules: a sickening number of mutations and protein functions.
Review
New
Mualla et al., In Adv Neurobiol, Dec 2013
L1-type proteins are transmembrane cell adhesion molecules with an evolutionary well-conserved protein domain structure of usually six immunoglobulin and five fibronectin type III domains.
Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV.
New
Impact
Fowell et al., Rochester, United States. In Nat Immunol, Sep 2013
Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin αV on effector CD4⁺ T cells.
The Significance of Matrix Metalloproteinases in Parasitic Infections Involving the Central Nervous System.
Review
Pinto et al., Roma, Italy. In Pathogens, 2012
For a long time, MMPs were considered only for the ability to degrade extracellular matrix (ECM) molecules (e.g., collagen, laminin, fibronectin) and to release hidden epitopes from the ECM.
Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells.
GeneRIF
Schwarzbauer et al., Princeton, United States. In Exp Cell Res, 2012
By providing cell adhesive signals that can act with other self-renewal factors to maintain embryonic stem cell pluripotency, fibronectin is a necessary component of the self-renewal signaling pathway in culture.
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin.
GeneRIF
Hakomori et al., Seattle, United States. In Febs Lett, 2012
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin
Inorganic phosphate stimulates fibronectin expression in renal fibroblasts.
GeneRIF
Moeckel et al., New Haven, United States. In Cell Physiol Biochem, 2011
the synthesis of fibronectin is mediated by a transcriptional complex consisting of NFATc1, osterix and c-Fos.
Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney.
GeneRIF
Ono et al., Fukuoka, Japan. In Cancer Biomark, 2010
Data suggest that fibronectin 1 (FN1) is a promising biomarker candidate for clear cell renal cell carcinoma (RCC).
Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells.
GeneRIF
Sudhakaran et al., Thiruvananthapuram, India. In Indian J Biochem Biophys, 2003
FN-dependent upregulation of MMPs is mediated through integrins
More papers using fibronectin antibodies
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
Supplier
Parsons Maddy, In PLoS ONE, 2008
... (Santa Cruz Biotechnology); mouse anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain ...
Multicellular spheroids in ovarian cancer metastases: Biology and pathology.
Supplier
Hotchin Neil A., In PLoS ONE, 2008
... Phenol red-free Matrigel and human fibronectin were acquired from BD Biosciences (Bedford, MA) ...
Optical tweezers for single cells
Supplier
Kumar Sanjay et al., In Annals of Biomedical Engineering, 2007
... For experiments, cells were plated on glass coverslips coated with human plasma fibronectin (Milipore Corp.) at various dilutions ...
Module map of stem cell genes guides creation of epithelial cancer stem cells.
Supplier
Waalkes Michael P. et al., In Environmental Health Perspectives, 2007
... Cell culture surfaces for SC were coated with type IV collagen (Trevigen, Gaithersburg, MD) and fibronectin (BD Biosciences, Bedford, MD) (2.5 μg ...
Early diagnosis of pancreatic cancer: Neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
Supplier
Schneider Guenter, In PLoS ONE, 2007
... and PANC1) or 250 000 cells (H6c7KrT) cells were seeded onto a 24-well dish coated with fibronectin and collagen (Sigma Aldrich, Mississauga, Canada) for 30 ...
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.
Supplier
Wieder Robert et al., In Cancer Microenvironment, 2007
... Cells were incubated at clonogenic densities of 50,000–75,000 cells per 10 cm fibronectin pre-coated plates purchased from BIOCOAT, BD Biosciences, or 15,000 cells per ...
Rac and Rap GTPase activation assays.
Supplier
Hartl Dominik, In PLoS ONE, 2006
... Cytocholasin B (1 µg/ml), nocodazole (10 nM), MTT (0.5 mg/ml), DAPI (1 µg/ml), PMA (100 ng/ml), fibronectin (10 µg/ml), human placenta collagen type VI (10 µg/ml) and rhodamine phalloidin were from Sigma Aldrich (St ...
Regulation of midbrain dopaminergic neuron development by Wnts, Sfrps and bHLH proteins.
Supplier
Hashimoto Kenji, In PLoS ONE, 2006
... Feeder-free cultures of BG01V2 were grown on human fibronectin, 20 µg/ml, (BD Biosciences, Bedford, U ...
Valproic acid, a histone deacetylase inhibitor, is an antagonist for oncolytic adenoviral gene therapy.
Supplier
Cheriyath Venugopalan, In PLoS ONE, 2005
... ng/ml triiodothyronine (Sigma Aldrich), 0.1 mM phosphoetanolamine, 50 ng/ml cholera toxin (Sigma Aldrich), 0.1 µg/ml fibronectin (Sigma Aldrich) and 20 µg/ml fetuin ...
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
Supplier
Durden Donald L. et al., In Cancer Chemotherapy and Pharmacology, 2005
... Vitronectin and fibronectin were purchased from BD Biosciences (Boston) ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Human fibronectin was from BD Biosciences.
Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration
Supplier
Tu Yaping et al., In Oncogene, 2004
... 2000, AlexaF488-labeled secondary antibody, RPMI-1640 and DMEM (Invitrogen); EGF, Matrigel and fibronectin (BD Biosciences); CXCL12 (R&D Systems); and ...
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
Supplier
Fuxe Jonas, In PLoS ONE, 2004
... Vimentin (#550513) and fibronectin (#610078) antibodies were products of BD Biosciences (Franklin Lakes, NJ) ...
The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development
Supplier
Khew-Goodall Yeesim et al., In The Journal of Cell Biology, 2004
... Anti–E-cadherin and anti-fibronectin mAbs were from Transduction Laboratories, anti-tubulin mAb was from Abcam, goat anti-actin pAb was ...
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Rhodamine-phalloidin was obtained from Invitrogen, and human fibronectin was obtained from BD Biosciences.
Synfire chains and cortical songs: Temporal modules of cortical activity.
Supplier
Ben-Jacob Eshel, In PLoS ONE, 2003
... in sterile water, Sigma), laminin (50 µg/mL in Dulbecco's phosphate buffer saline, D-PBS, R&D Systems), fibronectin (50 µg/mL in D-PBS, BD Biosciences), Matrigel (1∶100 v/v in ...
Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement
Supplier
Beckerle Mary C. et al., In The Journal of Cell Biology, 2002
... -lysine, and bovine plasma fibronectin were purchased from BD Biosciences and Sigma-Aldrich, respectively ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome
Supplier
Schliwa Manfred, In PLoS Biology, 2002
... Human fibronectin was from BD Biosciences Pharmingen (San Diego, California, ...
The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins
Supplier
Nawroth Peter P. et al., In The Journal of Experimental Medicine, 2002
... , FBG and fibronectin (FN) (Sigma-Aldrich), vitamin D3 (BIOMOL Research Laboratories, Inc.), transforming ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Supplier
Ploplis Victoria A et al., In Vascular Cell, 2002
... Vitronectin was from Sigma and fibronectin and rat-tail type I collagen was from BD Biosciences.
Efficient expression system of human recombinant laminin-5.
Supplier
Chakravarti Shukti, In PLoS ONE, 2001
... from EPITOMICS; Affinity purified rabbit anti-rat IgG from Vector Laboratories (Burlingame, CA); Purified human plasma fibronectin from Millipore; rat tail type I collagen from BD Transduction Laboratories; 3,3′-dithiobis[sulfosuccinimidylpropionate] (DTSSP) cross-linker from Thermo Scientific (Rockford, IL); and, Alexa ...
Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
Supplier
Burdmann Emmanuel A., In PLoS ONE, 2001
... Rabbit monoclonal antibody to GAPDH, mouse monoclonal antibody to fibronectin, goat anti-mouse IgG and anti-rabbit IgG secondary antibodies were from Santa Cruz Biotechnology, Inc ...
Rho GTPase signalling pathways in the morphological changes associated with apoptosis
Supplier
Zhang Zhigang et al., In Tumour Biology, 2001
... ], Collagen IV, fibronectin and laminin 1 were purchased from Merck Millipore (Danvers, MA) ...
Parathyroid hormone-related protein overexpression in the human colon cancer cell line HT-29 enhances adhesion of the cells to collagen type I
Supplier
Watson S A et al., In British Journal of Cancer, 2000
... The ECM proteins human fibronectin and mouse laminin-1 (derived from the EHS tumour) were purchased from BD Biosciences (Oxford, UK), whereas collagen ...
Cell senescence and cancer
Supplier
Chindasombatjaroen Jira et al., In International Journal of Oral Science, 2000
... Glostrup, Denmark), anti-laminin 1 (1∶60; Sigma Chemical Co.), anti-laminin 5 (1∶300; Chemicon International, Temecula, CA, USA) and anti-fibronectin (1∶400; Dako S/A) ...
Measurement of contractile forces generated by individual fibroblasts on self-standing fiber scaffolds
Supplier
Grigoropoulos Costas P. et al., In Biomedical Microdevices, 1999
... suspended fiber scaffolds were dipped in 70% ethanol for sterilization, exposed for coating to 20 μg/mL fibronectin (Sigma Aldrich) in phosphate buffered saline ...
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
Supplier
Taub Dennis D. et al., In International Journal of Medical Sciences, 1999
... 3T3-L1 preadipocytes were placed in fibronectin-coated plates (BD Biosciences, CA) in DMEM ...
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D
Supplier
Casanova James E. et al., In The Journal of Cell Biology, 1999
... Fibronectin was purchased from Becton Dickinson.
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis.
Supplier
Chammas Roger, In PLoS ONE, 1999
... Matrigel, collagen type I and fibronectin were purchased from BD Biosciences (Bedford, MA, USA) ...
Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility
Supplier
Brown Eric J. et al., In The Journal of Experimental Medicine, 1997
... Cells were harvested 10–18 d after plating and allowed to adhere to fibronectin-coated coverslips (Becton Dickinson) for infection with ...
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis
Supplier
Huynh-Do Uyen et al., In The Journal of Cell Biology, 1997
... Cell culture reagents and fibronectin were from Life Technologies, ephrinB2/Fc was from Immunex, ...
Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
Supplier
Turley Eva A. et al., In The Journal of Cell Biology, 1997
... Other reagents used were as follows: human plasma fibronectin (BD Biosciences), PDGF (PDGF-BB), and PMA ...
Functional association between promoter structure and transcript alternative splicing
Supplier
Muro Andrés F. et al., In Nucleic Acids Research, 1996
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Cross-linking of the NH2-terminal region of fibronectin to molecules of large apparent molecular mass
Supplier
McKeown-Longo Paula J. et al., In The Journal of Cell Biology, 1995
... (Temecula, CA); anti-fibronectin (3E3), anti-integrin subunits β5 (P1F6), and β1 (P4C10) were purchased from Life Technologies/ ...
Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung
Supplier
Keski-Oja Jorma et al., In The Journal of Cell Biology, 1994
... Anti-fibronectin antibodies used for immunofluorescence and immunohistochemistry were purchased from Sigma-Aldrich (FN-15) and Santa Cruz Biotechnology, Inc ...
Calcitonin gene-related peptide promotes Schwann cell proliferation.
Supplier
Raff Martin et al., In Journal of Biology, 1994
... The cells were expanded on poly-D-lysine- and fibronectin-coated culture dishes (Falcon; BD Biosciences, Oxford, UK) in 'complete ...
The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism
Supplier
Ruf Wolfram et al., In The Journal of Cell Biology, 1991
... Fibronectin was obtained from Collaborative Biomedical Products (Bedford, MA) and ...
Molecular Proximity of Kv1.3 Voltage-gated Potassium Channels and β1-Integrins on the Plasma Membrane of Melanoma Cells
Supplier
Petty Howard R. et al., In The Journal of General Physiology, 1990
... Fibronectin was purchased from Life Technologies.
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation.
Supplier
Katoh Masaru, In PLoS ONE, 1987
... with LHC-9 media (Invitrogen, Carlsbad, CA) in a 37°C, 5% CO2 incubator in dishes precoated with fibronectin (BD Biosciences, San Jose, CA), type ...
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 1980
... Human fibronectin was from BD Biosciences.
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins
Supplier
Zetter Bruce R. et al., In The Journal of Cell Biology, 1979
... Fibronectin was from BD Biosciences.
share on facebooktweetadd +1mail to friends