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Fibronectin 1

fibronectin
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, Actin, HAD, ACID
Papers using fibronectin antibodies
MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets.
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Tjwa Marc, In PLoS ONE, 2009
... Cor.At® cardiomyocytes each were then seeded onto Fibronectin-coated 10 cm dishes (Becton Dickinson, Heidelberg, Germany) in IMDM ...
Detection of novel 3′ untranslated region extensions with 3′ expression microarrays
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Muro Andrés Fernando et al., In Nucleic Acids Research, 2009
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Akt cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects
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Cho Jae Youl et al., In Mediators of Inflammation, 2009
... Fibronectin was obtained from BD Biosciences (San Diego, CA) ...
An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden in a pre-clinical model of ovarian cancer metastasis.
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Lengyel E et al., In Oncogene, 2009
... Anti FAK and paxillin antibodies, growth factor reduced matrigel and human fibronectin were from BD Biosciences (San Jose, CA), phospho-FAK ...
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
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Salh Baljinder et al., In BMC Immunology, 2008
... Anti-FoxP3 antibody was obtained from eBiosciences (San Diego, CA); anti-fibronectin antibody from Abcam (Cambridge, MA); anti-alpha 5 integrin ...
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Papers on fibronectin
Possible target-related proteins and signal network of bufalin in A549 cells suggested by both iTRAQ-based and label-free proteomic analysis.
New
Liu et al., Shanghai, China. In Proteomics, Feb 2016
And, fibronectin-related pathway was suggested to be an important pathway affected by BF.
Fetal fibronectin, cervical length, and the risk of preterm birth in patients with an ultrasound or physical exam indicated cervical cerclage.
New
Fox et al., New York City, United States. In J Matern Fetal Neonatal Med, Feb 2016
OBJECTIVE: To estimate the risk of preterm birth in patients with an ultrasound or physical exam indicated cervical cerclage based on the results of fetal fibronectin (fFN) and cervical length (CL) screening.
Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells.
New
Li et al., Mudanjiang, China. In Int J Oncol, Feb 2016
Besides, western blot analysis and immunofluorescence assay observed the significant decreased expression of E-cadherin and enhanced expression of slug, fibronectin and vimentin in SDF-1 overexpressed MCF-7 cells in comparison with parental (P<0.01).
Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.
Review
New
Kyriakides et al., New Haven, United States. In Adv Drug Deliv Rev, Feb 2016
These properties are mainly mediated by the activity of collagenous and elastic fibers, proteoglycans, and proteins such as fibronectin and laminin.
The Extracellular Matrix in Breast Cancer.
Review
New
Oskarsson et al., Heidelberg, Germany. In Adv Drug Deliv Rev, Jan 2016
Matrix proteins that are induced in breast cancer include fibrillar collagens, fibronectin, specific laminins and proteoglycans as well as matricellular proteins.
Fibronectin-targeted drug delivery in cancer.
Review
New
Reinhardt et al., Montréal, Canada. In Adv Drug Deliv Rev, Dec 2015
Alternative splicing of the precursor mRNA, produced from the single copy fibronectin gene, occurs at three sites coding for the EDA, EDB and IIICS domains.
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
New
Impact
Lyden et al., New York City, United States. In Nat Cell Biol, Jun 2015
Uptake of PDAC-derived exosomes by Kupffer cells caused transforming growth factor β secretion and upregulation of fibronectin production by hepatic stellate cells.
Conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces.
New
Impact
Feinberg et al., Pittsburgh, United States. In Nat Methods, Feb 2015
Our Patterning on Topography (PoT) printing technique enables fibronectin, laminin and other proteins to be applied to biomaterial surfaces in complex geometries that are inaccessible using traditional soft lithography techniques.
Extracellular matrix assembly: a multiscale deconstruction.
Review
Impact
Weaver et al., San Francisco, United States. In Nat Rev Mol Cell Biol, 2014
The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM.
Accentuating and Opposing Factors Leading to Development of Thoracic Aortic Aneurysms Not Due to Genetic or Inherited Conditions.
Review
Rabkin, Vancouver, Canada. In Front Cardiovasc Med, 2014
The major inhibitors or factors opposing TAA development are the constituents of the aortic wall (elastic lamellae, collagen, fibulins, fibronectin, proteoglycans, and vascular smooth muscle cells), which maintain normal aortic dimensions in the face of aortic wall stress, specific tissue MMP inhibitors, plasminogen activator inhibitor-1, protease nexin-1, and Syndecans.
Role of Irisin on the bone-muscle functional unit.
Review
Grano et al., Bari, Italy. In Bonekey Rep, 2014
Irisin was originally recognized as a hormone-like myokine secreted as a product of fibronectin type III domain containing 5 from skeletal muscle in response to exercise both in mice and humans.
Inhibition by a retinoic acid receptor γ agonist of extracellular matrix remodeling mediated by human Tenon fibroblasts.
Sonoda et al., Ube, Japan. In Mol Vis, 2014
Phosphorylation of focal adhesion kinase (FAK) was examined with immunoblot analysis, and production of fibronectin and type I collagen was measured with immunoassays.
Persistence of reduced expression of putative stem cell markers and slow wound healing in cultured diabetic limbal epithelial cells.
Ljubimov et al., Los Angeles, United States. In Mol Vis, 2014
LECs were cultured in EpiLife medium on human amniotic membrane (AM) denuded with mild alkali treatment, on plastic dishes and on glass slides coated with a mixture of human fibronectin, collagen type IV, and laminin (FCL).
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
Impact
Nikolov et al., New York City, United States. In Science, 2014
The differences result from different lengths of the linker connecting receptor domains fibronectin type III domain 4 (FN4) and FN5, which differs among DCC and neogenin splice variants, providing a basis for diverse signaling outcomes.
Rigidity sensing and adaptation through regulation of integrin types.
Impact
Roca-Cusachs et al., London, United Kingdom. In Nat Mater, 2014
Cell binding to fibronectin through either α5β1 integrins (constitutively expressed) or αvβ6 integrins (selectively expressed in cancer and development) adapts force generation, actin flow and integrin recruitment to rigidities associated with healthy or malignant tissue, respectively.
Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells.
GeneRIF
Schwarzbauer et al., Princeton, United States. In Exp Cell Res, 2012
By providing cell adhesive signals that can act with other self-renewal factors to maintain embryonic stem cell pluripotency, fibronectin is a necessary component of the self-renewal signaling pathway in culture.
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin.
GeneRIF
Hakomori et al., Seattle, United States. In Febs Lett, 2012
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin
Inorganic phosphate stimulates fibronectin expression in renal fibroblasts.
GeneRIF
Moeckel et al., New Haven, United States. In Cell Physiol Biochem, 2011
the synthesis of fibronectin is mediated by a transcriptional complex consisting of NFATc1, osterix and c-Fos.
Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney.
GeneRIF
Ono et al., Fukuoka, Japan. In Cancer Biomark, 2010
Data suggest that fibronectin 1 (FN1) is a promising biomarker candidate for clear cell renal cell carcinoma (RCC).
Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells.
GeneRIF
Sudhakaran et al., Thiruvananthapuram, India. In Indian J Biochem Biophys, 2003
FN-dependent upregulation of MMPs is mediated through integrins
More papers using fibronectin antibodies
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
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Parsons Maddy, In PLoS ONE, 2008
... (Santa Cruz Biotechnology); mouse anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain ...
Multicellular spheroids in ovarian cancer metastases: Biology and pathology.
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Hotchin Neil A., In PLoS ONE, 2008
... Phenol red-free Matrigel and human fibronectin were acquired from BD Biosciences (Bedford, MA) ...
Optical tweezers for single cells
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Kumar Sanjay et al., In Annals of Biomedical Engineering, 2007
... For experiments, cells were plated on glass coverslips coated with human plasma fibronectin (Milipore Corp.) at various dilutions ...
Module map of stem cell genes guides creation of epithelial cancer stem cells.
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Waalkes Michael P. et al., In Environmental Health Perspectives, 2007
... Cell culture surfaces for SC were coated with type IV collagen (Trevigen, Gaithersburg, MD) and fibronectin (BD Biosciences, Bedford, MD) (2.5 μg ...
Early diagnosis of pancreatic cancer: Neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
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Schneider Guenter, In PLoS ONE, 2007
... and PANC1) or 250 000 cells (H6c7KrT) cells were seeded onto a 24-well dish coated with fibronectin and collagen (Sigma Aldrich, Mississauga, Canada) for 30 ...
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.
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Wieder Robert et al., In Cancer Microenvironment, 2007
... Cells were incubated at clonogenic densities of 50,000–75,000 cells per 10 cm fibronectin pre-coated plates purchased from BIOCOAT, BD Biosciences, or 15,000 cells per ...
Rac and Rap GTPase activation assays.
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Hartl Dominik, In PLoS ONE, 2006
... Cytocholasin B (1 µg/ml), nocodazole (10 nM), MTT (0.5 mg/ml), DAPI (1 µg/ml), PMA (100 ng/ml), fibronectin (10 µg/ml), human placenta collagen type VI (10 µg/ml) and rhodamine phalloidin were from Sigma Aldrich (St ...
Regulation of midbrain dopaminergic neuron development by Wnts, Sfrps and bHLH proteins.
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Hashimoto Kenji, In PLoS ONE, 2006
... Feeder-free cultures of BG01V2 were grown on human fibronectin, 20 µg/ml, (BD Biosciences, Bedford, U ...
Valproic acid, a histone deacetylase inhibitor, is an antagonist for oncolytic adenoviral gene therapy.
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Cheriyath Venugopalan, In PLoS ONE, 2005
... ng/ml triiodothyronine (Sigma Aldrich), 0.1 mM phosphoetanolamine, 50 ng/ml cholera toxin (Sigma Aldrich), 0.1 µg/ml fibronectin (Sigma Aldrich) and 20 µg/ml fetuin ...
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
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Durden Donald L. et al., In Cancer Chemotherapy and Pharmacology, 2005
... Vitronectin and fibronectin were purchased from BD Biosciences (Boston) ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
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Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Human fibronectin was from BD Biosciences.
Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration
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Tu Yaping et al., In Oncogene, 2004
... 2000, AlexaF488-labeled secondary antibody, RPMI-1640 and DMEM (Invitrogen); EGF, Matrigel and fibronectin (BD Biosciences); CXCL12 (R&D Systems); and ...
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
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Fuxe Jonas, In PLoS ONE, 2004
... Vimentin (#550513) and fibronectin (#610078) antibodies were products of BD Biosciences (Franklin Lakes, NJ) ...
The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development
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Khew-Goodall Yeesim et al., In The Journal of Cell Biology, 2004
... Anti–E-cadherin and anti-fibronectin mAbs were from Transduction Laboratories, anti-tubulin mAb was from Abcam, goat anti-actin pAb was ...
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
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Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Rhodamine-phalloidin was obtained from Invitrogen, and human fibronectin was obtained from BD Biosciences.
Synfire chains and cortical songs: Temporal modules of cortical activity.
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Ben-Jacob Eshel, In PLoS ONE, 2003
... in sterile water, Sigma), laminin (50 µg/mL in Dulbecco's phosphate buffer saline, D-PBS, R&D Systems), fibronectin (50 µg/mL in D-PBS, BD Biosciences), Matrigel (1∶100 v/v in ...
Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement
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Beckerle Mary C. et al., In The Journal of Cell Biology, 2002
... -lysine, and bovine plasma fibronectin were purchased from BD Biosciences and Sigma-Aldrich, respectively ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome
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Schliwa Manfred, In PLoS Biology, 2002
... Human fibronectin was from BD Biosciences Pharmingen (San Diego, California, ...
The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins
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Nawroth Peter P. et al., In The Journal of Experimental Medicine, 2002
... , FBG and fibronectin (FN) (Sigma-Aldrich), vitamin D3 (BIOMOL Research Laboratories, Inc.), transforming ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
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Ploplis Victoria A et al., In Vascular Cell, 2002
... Vitronectin was from Sigma and fibronectin and rat-tail type I collagen was from BD Biosciences.
Efficient expression system of human recombinant laminin-5.
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Chakravarti Shukti, In PLoS ONE, 2001
... from EPITOMICS; Affinity purified rabbit anti-rat IgG from Vector Laboratories (Burlingame, CA); Purified human plasma fibronectin from Millipore; rat tail type I collagen from BD Transduction Laboratories; 3,3′-dithiobis[sulfosuccinimidylpropionate] (DTSSP) cross-linker from Thermo Scientific (Rockford, IL); and, Alexa ...
Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
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Burdmann Emmanuel A., In PLoS ONE, 2001
... Rabbit monoclonal antibody to GAPDH, mouse monoclonal antibody to fibronectin, goat anti-mouse IgG and anti-rabbit IgG secondary antibodies were from Santa Cruz Biotechnology, Inc ...
Rho GTPase signalling pathways in the morphological changes associated with apoptosis
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Zhang Zhigang et al., In Tumour Biology, 2001
... ], Collagen IV, fibronectin and laminin 1 were purchased from Merck Millipore (Danvers, MA) ...
Parathyroid hormone-related protein overexpression in the human colon cancer cell line HT-29 enhances adhesion of the cells to collagen type I
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Watson S A et al., In British Journal of Cancer, 2000
... The ECM proteins human fibronectin and mouse laminin-1 (derived from the EHS tumour) were purchased from BD Biosciences (Oxford, UK), whereas collagen ...
Cell senescence and cancer
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Chindasombatjaroen Jira et al., In International Journal of Oral Science, 2000
... Glostrup, Denmark), anti-laminin 1 (1∶60; Sigma Chemical Co.), anti-laminin 5 (1∶300; Chemicon International, Temecula, CA, USA) and anti-fibronectin (1∶400; Dako S/A) ...
Measurement of contractile forces generated by individual fibroblasts on self-standing fiber scaffolds
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Grigoropoulos Costas P. et al., In Biomedical Microdevices, 1999
... suspended fiber scaffolds were dipped in 70% ethanol for sterilization, exposed for coating to 20 μg/mL fibronectin (Sigma Aldrich) in phosphate buffered saline ...
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
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Taub Dennis D. et al., In International Journal of Medical Sciences, 1999
... 3T3-L1 preadipocytes were placed in fibronectin-coated plates (BD Biosciences, CA) in DMEM ...
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D
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Casanova James E. et al., In The Journal of Cell Biology, 1999
... Fibronectin was purchased from Becton Dickinson.
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis.
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Chammas Roger, In PLoS ONE, 1999
... Matrigel, collagen type I and fibronectin were purchased from BD Biosciences (Bedford, MA, USA) ...
Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility
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Brown Eric J. et al., In The Journal of Experimental Medicine, 1997
... Cells were harvested 10–18 d after plating and allowed to adhere to fibronectin-coated coverslips (Becton Dickinson) for infection with ...
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis
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Huynh-Do Uyen et al., In The Journal of Cell Biology, 1997
... Cell culture reagents and fibronectin were from Life Technologies, ephrinB2/Fc was from Immunex, ...
Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
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Turley Eva A. et al., In The Journal of Cell Biology, 1997
... Other reagents used were as follows: human plasma fibronectin (BD Biosciences), PDGF (PDGF-BB), and PMA ...
Functional association between promoter structure and transcript alternative splicing
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Muro Andrés F. et al., In Nucleic Acids Research, 1996
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Cross-linking of the NH2-terminal region of fibronectin to molecules of large apparent molecular mass
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McKeown-Longo Paula J. et al., In The Journal of Cell Biology, 1995
... (Temecula, CA); anti-fibronectin (3E3), anti-integrin subunits β5 (P1F6), and β1 (P4C10) were purchased from Life Technologies/ ...
Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung
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Keski-Oja Jorma et al., In The Journal of Cell Biology, 1994
... Anti-fibronectin antibodies used for immunofluorescence and immunohistochemistry were purchased from Sigma-Aldrich (FN-15) and Santa Cruz Biotechnology, Inc ...
Calcitonin gene-related peptide promotes Schwann cell proliferation.
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Raff Martin et al., In Journal of Biology, 1994
... The cells were expanded on poly-D-lysine- and fibronectin-coated culture dishes (Falcon; BD Biosciences, Oxford, UK) in 'complete ...
The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism
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Ruf Wolfram et al., In The Journal of Cell Biology, 1991
... Fibronectin was obtained from Collaborative Biomedical Products (Bedford, MA) and ...
Molecular Proximity of Kv1.3 Voltage-gated Potassium Channels and β1-Integrins on the Plasma Membrane of Melanoma Cells
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Petty Howard R. et al., In The Journal of General Physiology, 1990
... Fibronectin was purchased from Life Technologies.
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation.
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Katoh Masaru, In PLoS ONE, 1987
... with LHC-9 media (Invitrogen, Carlsbad, CA) in a 37°C, 5% CO2 incubator in dishes precoated with fibronectin (BD Biosciences, San Jose, CA), type ...
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
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Bourne Henry R. et al., In The Journal of Cell Biology, 1980
... Human fibronectin was from BD Biosciences.
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins
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Zetter Bruce R. et al., In The Journal of Cell Biology, 1979
... Fibronectin was from BD Biosciences.
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