GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Fibronectin 1
fibronectin
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
fibronectin
antibodies
An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden in a pre-clinical model of ovarian cancer metastasis.
Supplier
In Oncogene, 2009
... Anti FAK and paxillin antibodies, growth factor reduced matrigel and human fibronectin were from BD Biosciences (San Jose, CA), phospho-FAK ...
Detection of novel 3′ untranslated region extensions with 3′ expression microarrays
Supplier
In Nucleic Acids Research, 2009
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets.
Supplier
In PLoS ONE, 2009
... Cor.At® cardiomyocytes each were then seeded onto Fibronectin-coated 10 cm dishes (Becton Dickinson, Heidelberg, Germany) in IMDM ...
Akt cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects
Supplier
In Mediators of Inflammation, 2009
... Fibronectin was obtained from BD Biosciences (San Diego, CA) ...
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
more suppliersSupplier
In PLoS ONE, 2008
... (Santa Cruz Biotechnology); mouse anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain ...
Papers on
fibronectin
Peptide-mediated Inhibition of MK2 Ameliorates Bleomycin-Induced Pulmonary Fibrosis.
New
Indianapolis, United States. In Am J Respir Cell Mol Biol, 07 Apr 2013
In vitro, MK2i dose-dependently attenuated total MK2, myofibroblast differentiation, secretion of collagen type I, fibronectin, and FAK activation, while activated MK2 was attenuated at higher doses.
Direct Adhesion of Endothelial Cells to Bioinspired Poly(dopamine) Coating Through Endogenous Fibronectin and Integrin α5 β1.
New
Hangzhou, China. In Macromol Biosci, 07 Apr 2013
Endogenous fibronectin and α5 β1 integrin are found to be involved in the cell adhesion process.
A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein.
New
Ōsaka, Japan. In Biomaterials, 05 Apr 2013
A monobody, which is a single domain antibody mimic based on the tenth human fibronectin type III domain scaffold with a structure similar to the variable domains of antibodies, would be suitable as a targeting molecule for display on the Ad capsid proteins because of its highly stable structure even under reducing conditions and low molecular weight (approximately 10 kDa).
Irisin-immunoreactivity in neural and non-neural cells of the rodent.
New
Philadelphia, United States. In Neuroscience, 04 Apr 2013
Cerebellar Purkinje cells were also immunolabeled with an antiserum against fibronectin type II domain containing 5 (FNDC5), the precursor protein of irisin.
Substrates of Factor XIII-A: roles in thrombosis and wound healing.
Review
New
Leeds, United Kingdom. In Clin Sci (lond), 28 Feb 2013
The present review discusses the substrates of FXIIIa (activated FXIII) involved in thrombosis and wound healing with a particular focus on: (i) the influence of plasma FXIIIa on the formation of stable fibrin clots able to withstand mechanical and enzymatic breakdown through fibrin-fibrin cross-linking and cross-linking of fibrinolysis inhibitors, in particular α2-antiplasmin; (ii) the role of intracellular FXIIIa in clot retraction through cross-linking of platelet cytoskeleton proteins, including actin, myosin, filamin and vinculin; (iii) the role of intracellular FXIIIa in cross-linking the cytoplasmic tails of monocyte AT1Rs (angiotensin type 1 receptors) and potential effects on the development of atherosclerosis; and (iv) the role of FXIIIa on matrix deposition and tissue repair, including cross-linking of extracellular matrix proteins, such as fibronectin, collagen and von Willebrand factor, and the effects on matrix deposition and cell-matrix interactions.
The Novel Mas agonist, CGEN-856S, Attenuates Isoproterenol-Induced Cardiac Remodeling and Myocardial Infarction Injury in Rats.
New
Belo Horizonte, Brazil. In Plos One, Dec 2012
After a 7-day treatment period with CGEN-856S (90 µg·kg·day) or vehicle, the cardiomyocyte diameter was evaluated in left ventricular sections stained with hematoxylin and eosin, and immunofluorescence labeling and quantitative confocal microscopy were used to quantify the deposition of type I and III collagen and fibronectin in the left ventricles.
Bacterial adhesion to animal tissues: protein determinants for recognition of extracellular matrix components.
Review
New
France. In Cell Microbiol, Nov 2012
Constituted of the four main fibrous proteins, i.e. collagen, fibronectin, laminin and elastin, ECM components form a highly structured and functional network via specific interactions.
Elfn1 regulates target-specific release probability at CA1-interneuron synapses.
New
Impact
San Diego, United States. In Science, Nov 2012
Here, we show that the extracellular leucine-rich repeat fibronectin containing 1 (Elfn1) protein is selectively expressed by O-LM interneurons and regulates presynaptic release probability to direct the formation of highly facilitating pyramidal-O-LM synapses.
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions.
New
Impact
Bordeaux, France. In Nat Cell Biol, Oct 2012
Different fibronectin-binding integrins, simultaneously present in FAs, perform distinct functions.
Unanchoring integrins in focal adhesions.
New
Impact
In Nat Cell Biol, Oct 2012
A detailed analysis of integrin dynamics now indicates that focal-adhesion-associated integrins constantly switch between active and immobilized, and unbound and free-diffusing states, with different fibronectin-binding integrin heterodimers showing distinct focal-adhesion dynamics.
Cryoprecipitate: an outmoded treatment?
Review
New
Cambridge, United Kingdom. In Transfus Med, Oct 2012
It contains factors VIII, von Willebrand factor (vWF), fibrinogen, fibronectin and factor XIII.
The role of fibronectin in corneal wound healing explored by a physician-scientist.
Review
New
Yamaguchi, Japan. In Jpn J Ophthalmol, Sep 2012
The main focus of my translational research has been the role of fibronectin in corneal epithelial wound healing and the development of fibronectin eyedrops for the treatment of patients with persistent corneal epithelial defects.
Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes.
New
Impact
Leuven, Belgium. In N Engl J Med, Sep 2012
Ocriplasmin is a recombinant protease with activity against fibronectin and laminin, components of the vitreoretinal interface.
Fibronectin and stem cell differentiation - lessons from chondrogenesis.
Review
New
Princeton, United States. In J Cell Sci, Sep 2012
In particular, we focus on the main ECM protein fibronectin, its temporal expression pattern during chondrogenic differentiation, its potential effects on functions of differentiating chondrocytes, and how its interactions with other ECM components might affect cartilage development.
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.
New
Impact
Boston, United States. In Nature, Aug 2012
This effect is correlated with fibronectin upregulation and suppressed by inhibition of MAP3K7 (also known as TAK1) kinase.
A higher body temperature is associated with haemorrhagic transformation in patients with acute stroke untreated with recombinant tissue-type plasminogen activator (rtPA).
New
GeneRIF
Santiago de Compostela, Spain. In Clin Sci (lond), Feb 2012
Results show that higher body temperature within the first 24 h from stroke onset is associated with HT in acute ischaemic stroke untreated with rtPA, independently of biomarkers of BBB disruption, such as MMP-9 and cFn.
IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells.
GeneRIF
San Antonio, United States. In Am J Physiol Cell Physiol, 2012
Roles are evident for IGF-I-induced Akt phosphorylation and fibronectin expression in cultured kidney tubular epithelial cells.
miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line.
GeneRIF
Tianjin, China. In Febs Lett, 2011
miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line.
Contribution of unfolding and intermolecular architecture to fibronectin fiber extensibility.
GeneRIF
Boston, United States. In Biophys J, 2011
the extent of molecular unfolding that contributes to Fn fiber extension
Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.
More papers using
fibronectin
antibodies
GeneRIF
Bristol, United Kingdom. In Proc Natl Acad Sci U S A, 2011
The adhesive properties and thickness of the UspA1 layer at the cell surface varies on addition of either fibronectin or CEACAM1.
Multicellular spheroids in ovarian cancer metastases: Biology and pathology.
Supplier
In PLoS ONE, 2008
... Phenol red-free Matrigel and human fibronectin were acquired from BD Biosciences (Bedford, MA) ...
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
Supplier
In BMC Immunology, 2008
... Anti-FoxP3 antibody was obtained from eBiosciences (San Diego, CA); anti-fibronectin antibody from Abcam (Cambridge, MA); anti-alpha 5 integrin ...
Optical tweezers for single cells
Supplier
In Annals of Biomedical Engineering, 2007
... For experiments, cells were plated on glass coverslips coated with human plasma fibronectin (Milipore Corp.) at various dilutions ...
Module map of stem cell genes guides creation of epithelial cancer stem cells.
Supplier
In Environmental Health Perspectives, 2007
... Cell culture surfaces for SC were coated with type IV collagen (Trevigen, Gaithersburg, MD) and fibronectin (BD Biosciences, Bedford, MD) (2.5 μg ...
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.
Supplier
In Cancer Microenvironment, 2007
... Cells were incubated at clonogenic densities of 50,000–75,000 cells per 10 cm fibronectin pre-coated plates purchased from BIOCOAT, BD Biosciences, or 15,000 cells per ...
Early diagnosis of pancreatic cancer: Neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
Supplier
In PLoS ONE, 2007
... and PANC1) or 250 000 cells (H6c7KrT) cells were seeded onto a 24-well dish coated with fibronectin and collagen (Sigma Aldrich, Mississauga, Canada) for 30 ...
The Early Phagosomal Stage of Francisella tularensis Determines Optimal Phagosomal Escape and Francisella Pathogenicity Island Protein Expression.
Supplier
In PLoS ONE, 2007
... Fibronectin was purchased from BD Biosciences (Franklin Lakes, NJ) ...
Rac and Rap GTPase activation assays.
Supplier
In PLoS ONE, 2006
... Cytocholasin B (1 µg/ml), nocodazole (10 nM), MTT (0.5 mg/ml), DAPI (1 µg/ml), PMA (100 ng/ml), fibronectin (10 µg/ml), human placenta collagen type VI (10 µg/ml) and rhodamine phalloidin were from Sigma Aldrich (St ...
Regulation of midbrain dopaminergic neuron development by Wnts, Sfrps and bHLH proteins.
Supplier
In PLoS ONE, 2006
... Feeder-free cultures of BG01V2 were grown on human fibronectin, 20 µg/ml, (BD Biosciences, Bedford, U ...
Valproic acid, a histone deacetylase inhibitor, is an antagonist for oncolytic adenoviral gene therapy.
Supplier
In PLoS ONE, 2005
... ng/ml triiodothyronine (Sigma Aldrich), 0.1 mM phosphoetanolamine, 50 ng/ml cholera toxin (Sigma Aldrich), 0.1 µg/ml fibronectin (Sigma Aldrich) and 20 µg/ml fetuin ...
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
Supplier
In Cancer Chemotherapy and Pharmacology, 2005
... Vitronectin and fibronectin were purchased from BD Biosciences (Boston) ...
Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration
Supplier
In Oncogene, 2004
... 2000, AlexaF488-labeled secondary antibody, RPMI-1640 and DMEM (Invitrogen); EGF, Matrigel and fibronectin (BD Biosciences); CXCL12 (R&D Systems); and ...
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
Supplier
In The Journal of Cell Biology, 2004
... Rhodamine-phalloidin was obtained from Invitrogen, and human fibronectin was obtained from BD Biosciences.
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
Supplier
In PLoS ONE, 2004
... Vimentin (#550513) and fibronectin (#610078) antibodies were products of BD Biosciences (Franklin Lakes, NJ) ...
The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development
Supplier
In The Journal of Cell Biology, 2004
... Anti–E-cadherin and anti-fibronectin mAbs were from Transduction Laboratories, anti-tubulin mAb was from Abcam, goat anti-actin pAb was ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
Supplier
In The Journal of Cell Biology, 2004
... Human fibronectin was from BD Biosciences.
Synfire chains and cortical songs: Temporal modules of cortical activity.
Supplier
In PLoS ONE, 2003
... in sterile water, Sigma), laminin (50 µg/mL in Dulbecco's phosphate buffer saline, D-PBS, R&D Systems), fibronectin (50 µg/mL in D-PBS, BD Biosciences), Matrigel (1∶100 v/v in ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome
Supplier
In PLoS Biology, 2002
... Human fibronectin was from BD Biosciences Pharmingen (San Diego, California, ...
Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement
Supplier
In The Journal of Cell Biology, 2002
... -lysine, and bovine plasma fibronectin were purchased from BD Biosciences and Sigma-Aldrich, respectively ...
The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins
Supplier
In The Journal of Experimental Medicine, 2002
... , FBG and fibronectin (FN) (Sigma-Aldrich), vitamin D3 (BIOMOL Research Laboratories, Inc.), transforming ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Supplier
In Vascular Cell, 2002
... Vitronectin was from Sigma and fibronectin and rat-tail type I collagen was from BD Biosciences.
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases.
Supplier
In PLoS ONE, 2002
... Fibronectin (BD Biosciences) was freshly prepared from ...
Efficient expression system of human recombinant laminin-5.
Supplier
In PLoS ONE, 2001
... from EPITOMICS; Affinity purified rabbit anti-rat IgG from Vector Laboratories (Burlingame, CA); Purified human plasma fibronectin from Millipore; rat tail type I collagen from BD Transduction Laboratories; 3,3′-dithiobis[sulfosuccinimidylpropionate] (DTSSP) cross-linker from Thermo Scientific (Rockford, IL); and, Alexa ...
Rho GTPase signalling pathways in the morphological changes associated with apoptosis
Supplier
In Tumour Biology, 2001
... ], Collagen IV, fibronectin and laminin 1 were purchased from Merck Millipore (Danvers, MA) ...
Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
Supplier
In PLoS ONE, 2001
... Rabbit monoclonal antibody to GAPDH, mouse monoclonal antibody to fibronectin, goat anti-mouse IgG and anti-rabbit IgG secondary antibodies were from Santa Cruz Biotechnology, Inc ...
Parathyroid hormone-related protein overexpression in the human colon cancer cell line HT-29 enhances adhesion of the cells to collagen type I
Supplier
In British Journal of Cancer, 2000
... The ECM proteins human fibronectin and mouse laminin-1 (derived from the EHS tumour) were purchased from BD Biosciences (Oxford, UK), whereas collagen ...
Cell senescence and cancer
Supplier
In International Journal of Oral Science, 2000
... Glostrup, Denmark), anti-laminin 1 (1∶60; Sigma Chemical Co.), anti-laminin 5 (1∶300; Chemicon International, Temecula, CA, USA) and anti-fibronectin (1∶400; Dako S/A) ...
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis.
Supplier
In PLoS ONE, 1999
... Matrigel, collagen type I and fibronectin were purchased from BD Biosciences (Bedford, MA, USA) ...
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA
expression in human thymus increases with age and is associated with thymic atrophy
Supplier
In International Journal of Medical Sciences, 1999
... 3T3-L1 preadipocytes were placed in fibronectin-coated plates (BD Biosciences, CA) in DMEM ...
Measurement of contractile forces generated by individual fibroblasts on self-standing fiber scaffolds
Supplier
In Biomedical Microdevices, 1999
... suspended fiber scaffolds were dipped in 70% ethanol for sterilization, exposed for coating to 20 μg/mL fibronectin (Sigma Aldrich) in phosphate buffered saline ...
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D
Supplier
In The Journal of Cell Biology, 1999
... Fibronectin was purchased from Becton Dickinson.
Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility
Supplier
In The Journal of Experimental Medicine, 1997
... Cells were harvested 10–18 d after plating and allowed to adhere to fibronectin-coated coverslips (Becton Dickinson) for infection with ...
Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
Supplier
In The Journal of Cell Biology, 1997
... Other reagents used were as follows: human plasma fibronectin (BD Biosciences), PDGF (PDGF-BB), and PMA ...
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis
Supplier
In The Journal of Cell Biology, 1997
... Cell culture reagents and fibronectin were from Life Technologies, ephrinB2/Fc was from Immunex, ...
Functional association between promoter structure and transcript alternative splicing
Supplier
In Nucleic Acids Research, 1996
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Cross-linking of the NH2-terminal region of fibronectin to molecules of large apparent molecular mass
Supplier
In The Journal of Cell Biology, 1995
... (Temecula, CA); anti-fibronectin (3E3), anti-integrin subunits β5 (P1F6), and β1 (P4C10) were purchased from Life Technologies/ ...
Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung
Supplier
In The Journal of Cell Biology, 1994
... Anti-fibronectin antibodies used for immunofluorescence and immunohistochemistry were purchased from Sigma-Aldrich (FN-15) and Santa Cruz Biotechnology, Inc ...
Calcitonin gene-related peptide promotes Schwann cell proliferation.
Supplier
In Journal of Biology, 1994
... The cells were expanded on poly-D-lysine- and fibronectin-coated culture dishes (Falcon; BD Biosciences, Oxford, UK) in 'complete ...
The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism
Supplier
In The Journal of Cell Biology, 1991
... Fibronectin was obtained from Collaborative Biomedical Products (Bedford, MA) and ...
Molecular Proximity of Kv1.3 Voltage-gated Potassium Channels and β1-Integrins on the Plasma Membrane of Melanoma Cells
Supplier
In The Journal of General Physiology, 1990
... Fibronectin was purchased from Life Technologies.
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation.
Supplier
In PLoS ONE, 1987
... with LHC-9 media (Invitrogen, Carlsbad, CA) in a 37°C, 5% CO2 incubator in dishes precoated with fibronectin (BD Biosciences, San Jose, CA), type ...
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
Supplier
In The Journal of Cell Biology, 1980
... Human fibronectin was from BD Biosciences.
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins
Supplier
In The Journal of Cell Biology, 1979
... Fibronectin was from BD Biosciences.
