gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Fibronectin 1

fibronectin
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, Actin, HAD, ACID
Papers using fibronectin antibodies
MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets.
Supplier
Tjwa Marc, In PLoS ONE, 2009
... Cor.At® cardiomyocytes each were then seeded onto Fibronectin-coated 10 cm dishes (Becton Dickinson, Heidelberg, Germany) in IMDM ...
Detection of novel 3′ untranslated region extensions with 3′ expression microarrays
Supplier
Muro Andrés Fernando et al., In Nucleic Acids Research, 2009
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Akt cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects
Supplier
Cho Jae Youl et al., In Mediators of Inflammation, 2009
... Fibronectin was obtained from BD Biosciences (San Diego, CA) ...
An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden in a pre-clinical model of ovarian cancer metastasis.
Supplier
Lengyel E et al., In Oncogene, 2009
... Anti FAK and paxillin antibodies, growth factor reduced matrigel and human fibronectin were from BD Biosciences (San Jose, CA), phospho-FAK ...
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
Supplier
Salh Baljinder et al., In BMC Immunology, 2008
... Anti-FoxP3 antibody was obtained from eBiosciences (San Diego, CA); anti-fibronectin antibody from Abcam (Cambridge, MA); anti-alpha 5 integrin ...
more suppliers
Papers on fibronectin
Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.
New
Milligan et al., In Biochem J, 27 Apr 2014
Deletion of both the immunoglobulin and fibronectin type III extracellular repeats prevented dimer formation, with the immunoglobulin repeats providing the bulk of the protein-protein interaction affinity.
Hypoxia induced changes in Ca2+ mobilization and protein phosphorylation implicated in impaired wound healing.
New
Trinkaus-Randall et al., Boston, United States. In Am J Physiol Cell Physiol, 26 Apr 2014
There was a change in the recruitment of paxillin to the cell membrane and deposition of fibronectin along the basal lamina, both factors in cell migration.
Albumin inhibits the insulin-mediated ACE2 increase in cultured podocytes.
New
Soler et al., In Am J Physiol Renal Physiol, 26 Apr 2014
Furthermore, insulin favored an "anti-angiotensin-II" regarding ACE/ACE2 gene expression balance and decreased fibronectin gene expression as a marker of fibrosis in the podocytes, all studied by real-time PCR.
Non-collagenous ECM proteins in blood vessel morphogenesis and cancer.
Review
New
Papalazarou et al., Athens, Greece. In Biochim Biophys Acta, 24 Mar 2014
Besides collagens, fibronectin and laminin are two major fiber-forming constituents of various ECM structures.
Mesenchymal stem cells, neural lineage potential, heparan sulfate proteoglycans and the matrix.
Review
New
Haupt et al., Brisbane, Australia. In Dev Biol, 06 Mar 2014
In addition, the heparan sulfate (HS) and chondroitin sulfate (CS) families of PGs interact directly with a number of growth factors, signalling pathways and ECM components including FGFs, Wnts and fibronectin.
Irisin as a muscle-derived hormone stimulating thermogenesis - A critical update.
Review
New
Stengel et al., Berlin, Germany. In Peptides, 26 Feb 2014
UNLABELLED: The recently described myokine, irisin is cleaved from fibronectin type III domain containing protein 5 (FNDC5) and has been proposed to be secreted upon exercise to promote the browning of beige fat cells in white adipose tissue that results in enhanced thermogenesis and increased energy expenditure.
Insights into the role of components of the tumor microenvironment in oral carcinoma call for new therapeutic approaches.
Review
New
Dayan et al., Oulu, Finland. In Exp Cell Res, 22 Feb 2014
The TME contains a variety of components including the non-cancerous cells (i.e., immune cells, resident fibroblasts and angiogenic vascular cells) and the ECM milieu [including fibers (mainly collagen and fibronectin) and soluble factors (i.e., enzymes, growth factors, cytokines and chemokines)].
Epithelial bridges maintain tissue integrity during collective cell migration.
New
Impact
Ladoux et al., Singapore, Singapore. In Nat Mater, Jan 2014
Here, we show that monolayers of human keratinocytes migrating along functionalized micropatterned surfaces comprising alternating strips of extracellular matrix (fibronectin) and non-adherent polymer form suspended multicellular bridges over the non-adherent areas.
[Ultrasound evaluation of fetal adrenal gland volume. The role of fetal adrenal glands in the pathogenesis of preterm labor].
Review
New
Kwaśniewska et al., Lublin, Poland. In Ginekol Pol, Jan 2014
They have also suggested that in a physiological pregnancy the relation between fetal zone and the whole organ remains constant throughout the pregnancy Disruption of these proportions and fetal zone enlargement are considered to be a marker of labor cascade and preterm labor with significantly higher sensitivity and specificity than ultrasound evaluation of the cervical length and assessment of the fetal fibronectin concentration.
9-cis-Retinoic Acid and Troglitazone Impacts Cellular Adhesion, Proliferation, and Integrin Expression in K562 Cells.
New
Kelley et al., Conway, United States. In Plos One, Dec 2013
Troglitazone exposure decreased K562 cellular adhesion to RGD containing extracellular matrix proteins fibronectin, FN-120, and vitronectin in a concentration and time-dependent manner.
Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV.
New
Impact
Fowell et al., Rochester, United States. In Nat Immunol, Sep 2013
Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin αV on effector CD4⁺ T cells.
An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks.
New
Impact
Garcia et al., Stanford, United States. In Cell, Aug 2013
We probed interactions between receptor extracellular domains, focusing on a set of 202 proteins composed of the Drosophila melanogaster immunoglobulin superfamily (IgSF), fibronectin type III (FnIII), and leucine-rich repeat (LRR) families, which are known to be important in neuronal and developmental functions.
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments.
New
Impact
Fässler et al., Martinsried, Germany. In Nat Cell Biol, Jun 2013
We report the functional analysis of β1- and αv-class integrins expressed in pan-integrin-null fibroblasts seeded on fibronectin.
Expression of carbonic anhydrase in the fetal eye and extra-ocular tissues.
Cho et al., Tokyo, Japan. In Okajimas Folia Anat Jpn, 2012
Any of matrix substances (collagen types I and II, aggrecan, versican, fibronectin, tenascin and hyaluronan) displayed a distribution pattern specific for the CA9-positive fibrous tissues.
Elfn1 regulates target-specific release probability at CA1-interneuron synapses.
Impact
Ghosh et al., San Diego, United States. In Science, 2012
Here, we show that the extracellular leucine-rich repeat fibronectin containing 1 (Elfn1) protein is selectively expressed by O-LM interneurons and regulates presynaptic release probability to direct the formation of highly facilitating pyramidal-O-LM synapses.
Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells.
GeneRIF
Schwarzbauer et al., Princeton, United States. In Exp Cell Res, 2012
By providing cell adhesive signals that can act with other self-renewal factors to maintain embryonic stem cell pluripotency, fibronectin is a necessary component of the self-renewal signaling pathway in culture.
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin.
GeneRIF
Hakomori et al., Seattle, United States. In Febs Lett, 2012
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin
Inorganic phosphate stimulates fibronectin expression in renal fibroblasts.
GeneRIF
Moeckel et al., New Haven, United States. In Cell Physiol Biochem, 2011
the synthesis of fibronectin is mediated by a transcriptional complex consisting of NFATc1, osterix and c-Fos.
Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney.
GeneRIF
Ono et al., Fukuoka, Japan. In Cancer Biomark, 2010
Data suggest that fibronectin 1 (FN1) is a promising biomarker candidate for clear cell renal cell carcinoma (RCC).
Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells.
GeneRIF
Sudhakaran et al., Thiruvananthapuram, India. In Indian J Biochem Biophys, 2003
FN-dependent upregulation of MMPs is mediated through integrins
More papers using fibronectin antibodies
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
Supplier
Parsons Maddy, In PLoS ONE, 2008
... (Santa Cruz Biotechnology); mouse anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain ...
Multicellular spheroids in ovarian cancer metastases: Biology and pathology.
Supplier
Hotchin Neil A., In PLoS ONE, 2008
... Phenol red-free Matrigel and human fibronectin were acquired from BD Biosciences (Bedford, MA) ...
Optical tweezers for single cells
Supplier
Kumar Sanjay et al., In Annals of Biomedical Engineering, 2007
... For experiments, cells were plated on glass coverslips coated with human plasma fibronectin (Milipore Corp.) at various dilutions ...
Module map of stem cell genes guides creation of epithelial cancer stem cells.
Supplier
Waalkes Michael P. et al., In Environmental Health Perspectives, 2007
... Cell culture surfaces for SC were coated with type IV collagen (Trevigen, Gaithersburg, MD) and fibronectin (BD Biosciences, Bedford, MD) (2.5 μg ...
Early diagnosis of pancreatic cancer: Neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
Supplier
Schneider Guenter, In PLoS ONE, 2007
... and PANC1) or 250 000 cells (H6c7KrT) cells were seeded onto a 24-well dish coated with fibronectin and collagen (Sigma Aldrich, Mississauga, Canada) for 30 ...
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.
Supplier
Wieder Robert et al., In Cancer Microenvironment, 2007
... Cells were incubated at clonogenic densities of 50,000–75,000 cells per 10 cm fibronectin pre-coated plates purchased from BIOCOAT, BD Biosciences, or 15,000 cells per ...
Rac and Rap GTPase activation assays.
Supplier
Hartl Dominik, In PLoS ONE, 2006
... Cytocholasin B (1 µg/ml), nocodazole (10 nM), MTT (0.5 mg/ml), DAPI (1 µg/ml), PMA (100 ng/ml), fibronectin (10 µg/ml), human placenta collagen type VI (10 µg/ml) and rhodamine phalloidin were from Sigma Aldrich (St ...
Regulation of midbrain dopaminergic neuron development by Wnts, Sfrps and bHLH proteins.
Supplier
Hashimoto Kenji, In PLoS ONE, 2006
... Feeder-free cultures of BG01V2 were grown on human fibronectin, 20 µg/ml, (BD Biosciences, Bedford, U ...
Valproic acid, a histone deacetylase inhibitor, is an antagonist for oncolytic adenoviral gene therapy.
Supplier
Cheriyath Venugopalan, In PLoS ONE, 2005
... ng/ml triiodothyronine (Sigma Aldrich), 0.1 mM phosphoetanolamine, 50 ng/ml cholera toxin (Sigma Aldrich), 0.1 µg/ml fibronectin (Sigma Aldrich) and 20 µg/ml fetuin ...
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
Supplier
Durden Donald L. et al., In Cancer Chemotherapy and Pharmacology, 2005
... Vitronectin and fibronectin were purchased from BD Biosciences (Boston) ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Human fibronectin was from BD Biosciences.
Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration
Supplier
Tu Yaping et al., In Oncogene, 2004
... 2000, AlexaF488-labeled secondary antibody, RPMI-1640 and DMEM (Invitrogen); EGF, Matrigel and fibronectin (BD Biosciences); CXCL12 (R&D Systems); and ...
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
Supplier
Fuxe Jonas, In PLoS ONE, 2004
... Vimentin (#550513) and fibronectin (#610078) antibodies were products of BD Biosciences (Franklin Lakes, NJ) ...
The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development
Supplier
Khew-Goodall Yeesim et al., In The Journal of Cell Biology, 2004
... Anti–E-cadherin and anti-fibronectin mAbs were from Transduction Laboratories, anti-tubulin mAb was from Abcam, goat anti-actin pAb was ...
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Rhodamine-phalloidin was obtained from Invitrogen, and human fibronectin was obtained from BD Biosciences.
Synfire chains and cortical songs: Temporal modules of cortical activity.
Supplier
Ben-Jacob Eshel, In PLoS ONE, 2003
... in sterile water, Sigma), laminin (50 µg/mL in Dulbecco's phosphate buffer saline, D-PBS, R&D Systems), fibronectin (50 µg/mL in D-PBS, BD Biosciences), Matrigel (1∶100 v/v in ...
Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement
Supplier
Beckerle Mary C. et al., In The Journal of Cell Biology, 2002
... -lysine, and bovine plasma fibronectin were purchased from BD Biosciences and Sigma-Aldrich, respectively ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome
Supplier
Schliwa Manfred, In PLoS Biology, 2002
... Human fibronectin was from BD Biosciences Pharmingen (San Diego, California, ...
The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins
Supplier
Nawroth Peter P. et al., In The Journal of Experimental Medicine, 2002
... , FBG and fibronectin (FN) (Sigma-Aldrich), vitamin D3 (BIOMOL Research Laboratories, Inc.), transforming ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Supplier
Ploplis Victoria A et al., In Vascular Cell, 2002
... Vitronectin was from Sigma and fibronectin and rat-tail type I collagen was from BD Biosciences.
Efficient expression system of human recombinant laminin-5.
Supplier
Chakravarti Shukti, In PLoS ONE, 2001
... from EPITOMICS; Affinity purified rabbit anti-rat IgG from Vector Laboratories (Burlingame, CA); Purified human plasma fibronectin from Millipore; rat tail type I collagen from BD Transduction Laboratories; 3,3′-dithiobis[sulfosuccinimidylpropionate] (DTSSP) cross-linker from Thermo Scientific (Rockford, IL); and, Alexa ...
Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
Supplier
Burdmann Emmanuel A., In PLoS ONE, 2001
... Rabbit monoclonal antibody to GAPDH, mouse monoclonal antibody to fibronectin, goat anti-mouse IgG and anti-rabbit IgG secondary antibodies were from Santa Cruz Biotechnology, Inc ...
Rho GTPase signalling pathways in the morphological changes associated with apoptosis
Supplier
Zhang Zhigang et al., In Tumour Biology, 2001
... ], Collagen IV, fibronectin and laminin 1 were purchased from Merck Millipore (Danvers, MA) ...
Parathyroid hormone-related protein overexpression in the human colon cancer cell line HT-29 enhances adhesion of the cells to collagen type I
Supplier
Watson S A et al., In British Journal of Cancer, 2000
... The ECM proteins human fibronectin and mouse laminin-1 (derived from the EHS tumour) were purchased from BD Biosciences (Oxford, UK), whereas collagen ...
Cell senescence and cancer
Supplier
Chindasombatjaroen Jira et al., In International Journal of Oral Science, 2000
... Glostrup, Denmark), anti-laminin 1 (1∶60; Sigma Chemical Co.), anti-laminin 5 (1∶300; Chemicon International, Temecula, CA, USA) and anti-fibronectin (1∶400; Dako S/A) ...
Measurement of contractile forces generated by individual fibroblasts on self-standing fiber scaffolds
Supplier
Grigoropoulos Costas P. et al., In Biomedical Microdevices, 1999
... suspended fiber scaffolds were dipped in 70% ethanol for sterilization, exposed for coating to 20 μg/mL fibronectin (Sigma Aldrich) in phosphate buffered saline ...
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
Supplier
Taub Dennis D. et al., In International Journal of Medical Sciences, 1999
... 3T3-L1 preadipocytes were placed in fibronectin-coated plates (BD Biosciences, CA) in DMEM ...
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D
Supplier
Casanova James E. et al., In The Journal of Cell Biology, 1999
... Fibronectin was purchased from Becton Dickinson.
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis.
Supplier
Chammas Roger, In PLoS ONE, 1999
... Matrigel, collagen type I and fibronectin were purchased from BD Biosciences (Bedford, MA, USA) ...
Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility
Supplier
Brown Eric J. et al., In The Journal of Experimental Medicine, 1997
... Cells were harvested 10–18 d after plating and allowed to adhere to fibronectin-coated coverslips (Becton Dickinson) for infection with ...
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis
Supplier
Huynh-Do Uyen et al., In The Journal of Cell Biology, 1997
... Cell culture reagents and fibronectin were from Life Technologies, ephrinB2/Fc was from Immunex, ...
Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
Supplier
Turley Eva A. et al., In The Journal of Cell Biology, 1997
... Other reagents used were as follows: human plasma fibronectin (BD Biosciences), PDGF (PDGF-BB), and PMA ...
Functional association between promoter structure and transcript alternative splicing
Supplier
Muro Andrés F. et al., In Nucleic Acids Research, 1996
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Cross-linking of the NH2-terminal region of fibronectin to molecules of large apparent molecular mass
Supplier
McKeown-Longo Paula J. et al., In The Journal of Cell Biology, 1995
... (Temecula, CA); anti-fibronectin (3E3), anti-integrin subunits β5 (P1F6), and β1 (P4C10) were purchased from Life Technologies/ ...
Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung
Supplier
Keski-Oja Jorma et al., In The Journal of Cell Biology, 1994
... Anti-fibronectin antibodies used for immunofluorescence and immunohistochemistry were purchased from Sigma-Aldrich (FN-15) and Santa Cruz Biotechnology, Inc ...
Calcitonin gene-related peptide promotes Schwann cell proliferation.
Supplier
Raff Martin et al., In Journal of Biology, 1994
... The cells were expanded on poly-D-lysine- and fibronectin-coated culture dishes (Falcon; BD Biosciences, Oxford, UK) in 'complete ...
The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism
Supplier
Ruf Wolfram et al., In The Journal of Cell Biology, 1991
... Fibronectin was obtained from Collaborative Biomedical Products (Bedford, MA) and ...
Molecular Proximity of Kv1.3 Voltage-gated Potassium Channels and β1-Integrins on the Plasma Membrane of Melanoma Cells
Supplier
Petty Howard R. et al., In The Journal of General Physiology, 1990
... Fibronectin was purchased from Life Technologies.
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation.
Supplier
Katoh Masaru, In PLoS ONE, 1987
... with LHC-9 media (Invitrogen, Carlsbad, CA) in a 37°C, 5% CO2 incubator in dishes precoated with fibronectin (BD Biosciences, San Jose, CA), type ...
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 1980
... Human fibronectin was from BD Biosciences.
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins
Supplier
Zetter Bruce R. et al., In The Journal of Cell Biology, 1979
... Fibronectin was from BD Biosciences.
share on facebooktweetadd +1mail to friends