GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 05 Mar 2015.
Fibronectin 1
fibronectin
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
CAN, V1a, Actin, HAD, ACID
Papers using
fibronectin
antibodies
MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets.
Supplier
In PLoS ONE, 2009
... Cor.At® cardiomyocytes each were then seeded onto Fibronectin-coated 10 cm dishes (Becton Dickinson, Heidelberg, Germany) in IMDM ...
Detection of novel 3′ untranslated region extensions with 3′ expression microarrays
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In Nucleic Acids Research, 2009
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Akt cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects
Supplier
In Mediators of Inflammation, 2009
... Fibronectin was obtained from BD Biosciences (San Diego, CA) ...
An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden in a pre-clinical model of ovarian cancer metastasis.
Supplier
In Oncogene, 2009
... Anti FAK and paxillin antibodies, growth factor reduced matrigel and human fibronectin were from BD Biosciences (San Jose, CA), phospho-FAK ...
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
more suppliersSupplier
In BMC Immunology, 2008
... Anti-FoxP3 antibody was obtained from eBiosciences (San Diego, CA); anti-fibronectin antibody from Abcam (Cambridge, MA); anti-alpha 5 integrin ...
Papers on
fibronectin
Bioactive cell-derived matrices combined with polymer mesh scaffold for osteogenesis and bone healing.
New
Seoul, South Korea. In Biomaterials, 31 May 2015
The results showed that alkaline phosphatase (ALP) activity, mineralization, and osteogenic marker expression were significantly improved with hPMSCs cultured in the hFDM-coated mesh scaffolds compared to the control and fibronectin-coated ones.
Identification of biological processes and genes for gestational diabetes mellitus.
New
Wuhan, China. In Arch Gynecol Obstet, 04 Apr 2015
Hub genes including fibronectin 1 (FN1) and insulin-like growth factor 1 (IGF1) were down-regulated, and leptin (LEP) and calmodulin 1 (CALM1) were up-regulated.
Structure and dynamics of the fibronectin-III domains of Aplysia californica cell adhesion molecules.
New
Dublin, Ireland. In Phys Chem Chem Phys, 02 Apr 2015
We study the molecular structures and conformational dynamics of the two fibronectin type III (Fn-III) extracellular domains of the Aplysia californica CAM (apCAM) protein, by constructing and probing an atomically-detailed structural model based on apCAM's homology with other CAMs.
Radiation-induced motility alterations in medulloblastoma cells.
New
Heidelberg, Germany. In J Radiat Res (tokyo), 02 Apr 2015
Both photon and carbon ion irradiation significantly reduced chemotactic medulloblastoma cell transmigration through 8-μm pore size membranes, while simultaneously increasing adherence to fibronectin- and collagen I- and IV-coated surfaces.
Small GTPase Rab21 Mediates Fibronectin Induced Actin Reorganization in Entamoeba histolytica: Implications in Pathogen Invasion.
New
Bhopāl, India. In Plos Pathog, 31 Mar 2015
Here, we showed that fibronectin, a major host ECM component induced actin remodeling in the parasite in a Rab21 dependent manner.
Conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces.
New
Impact
Pittsburgh, United States. In Nat Methods, 28 Feb 2015
Our Patterning on Topography (PoT) printing technique enables fibronectin, laminin and other proteins to be applied to biomaterial surfaces in complex geometries that are inaccessible using traditional soft lithography techniques.
Pathophysiological aspects of thyroid hormone disorders/thyroid peroxidase autoantibodies and reproduction.
Review
New
Amsterdam, Netherlands. In Hum Reprod Update, 28 Feb 2015
T3 increases the expression of matrix metalloproteinases (MMP), MMP-2, MMP-3, fetal fibronectin and integrin α5β1T3 in early placental extravillous trophoblasts.
A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins.
New
Modena, Italy. In J Photochem Photobiol B, 06 Feb 2015
We designed a first study to assess differences in facial skin pH, sebum, elasticity, hydration and tonicity and serum levels of fibronectin, elastin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins between patients affected by facial photoaging and healthy controls.
Use of umbilical cord serum in ophthalmology.
Review
New
Kwangju, South Korea. In Chonnam Med J, Dec 2014
Like peripheral blood serum, umbilical cord blood serum contains a high concentration of essential tear components, growth factors, neurotrophic factors, vitamin A, fibronectin, prealbumin, and oil.
The molecular basis of leptospiral pathogenesis.
Review
New
Melbourne, Australia. In Curr Top Microbiol Immunol, Dec 2014
Significant advances have also been made in the in vitro characterization of leptospiral interaction with host structures, including extracellular matrix proteins (such as laminin, elastin, fibronectin, collagens), proteins related to hemostasis (fibrinogen, plasmin), and soluble mediators of complement resistance (factor H, C4b-binding protein), although none of these in vitro findings has been translated to the host animal.
Extracellular matrix assembly: a multiscale deconstruction.
Review
New
Impact
San Francisco, United States. In Nat Rev Mol Cell Biol, Dec 2014
The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM.
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
New
Impact
New York City, United States. In Science, Jul 2014
The differences result from different lengths of the linker connecting receptor domains fibronectin type III domain 4 (FN4) and FN5, which differs among DCC and neogenin splice variants, providing a basis for diverse signaling outcomes.
Rigidity sensing and adaptation through regulation of integrin types.
New
Impact
London, United Kingdom. In Nat Mater, Jun 2014
Cell binding to fibronectin through either α5β1 integrins (constitutively expressed) or αvβ6 integrins (selectively expressed in cancer and development) adapts force generation, actin flow and integrin recruitment to rigidities associated with healthy or malignant tissue, respectively.
Epithelial bridges maintain tissue integrity during collective cell migration.
Impact
Singapore, Singapore. In Nat Mater, 2014
Here, we show that monolayers of human keratinocytes migrating along functionalized micropatterned surfaces comprising alternating strips of extracellular matrix (fibronectin) and non-adherent polymer form suspended multicellular bridges over the non-adherent areas.
The significance of matrix metalloproteinases in parasitic infections involving the central nervous system.
Review
Roma, Italy. In Pathogens, 2012
For a long time, MMPs were considered only for the ability to degrade extracellular matrix (ECM) molecules (e.g., collagen, laminin, fibronectin) and to release hidden epitopes from the ECM.
Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells.
GeneRIF
Princeton, United States. In Exp Cell Res, 2012
By providing cell adhesive signals that can act with other self-renewal factors to maintain embryonic stem cell pluripotency, fibronectin is a necessary component of the self-renewal signaling pathway in culture.
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin.
GeneRIF
Seattle, United States. In Febs Lett, 2012
Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin
Inorganic phosphate stimulates fibronectin expression in renal fibroblasts.
GeneRIF
New Haven, United States. In Cell Physiol Biochem, 2011
the synthesis of fibronectin is mediated by a transcriptional complex consisting of NFATc1, osterix and c-Fos.
Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney.
GeneRIF
Fukuoka, Japan. In Cancer Biomark, 2010
Data suggest that fibronectin 1 (FN1) is a promising biomarker candidate for clear cell renal cell carcinoma (RCC).
Fibronectin dependent upregulation of matrix metalloproteinases in hepatic stellate cells.
More papers using
fibronectin
antibodies
GeneRIF
Thiruvananthapuram, India. In Indian J Biochem Biophys, 2003
FN-dependent upregulation of MMPs is mediated through integrins
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
Supplier
In PLoS ONE, 2008
... (Santa Cruz Biotechnology); mouse anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain ...
Multicellular spheroids in ovarian cancer metastases: Biology and pathology.
Supplier
In PLoS ONE, 2008
... Phenol red-free Matrigel and human fibronectin were acquired from BD Biosciences (Bedford, MA) ...
Optical tweezers for single cells
Supplier
In Annals of Biomedical Engineering, 2007
... For experiments, cells were plated on glass coverslips coated with human plasma fibronectin (Milipore Corp.) at various dilutions ...
Module map of stem cell genes guides creation of epithelial cancer stem cells.
Supplier
In Environmental Health Perspectives, 2007
... Cell culture surfaces for SC were coated with type IV collagen (Trevigen, Gaithersburg, MD) and fibronectin (BD Biosciences, Bedford, MD) (2.5 μg ...
Early diagnosis of pancreatic cancer: Neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
Supplier
In PLoS ONE, 2007
... and PANC1) or 250 000 cells (H6c7KrT) cells were seeded onto a 24-well dish coated with fibronectin and collagen (Sigma Aldrich, Mississauga, Canada) for 30 ...
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.
Supplier
In Cancer Microenvironment, 2007
... Cells were incubated at clonogenic densities of 50,000–75,000 cells per 10 cm fibronectin pre-coated plates purchased from BIOCOAT, BD Biosciences, or 15,000 cells per ...
The Early Phagosomal Stage of Francisella tularensis Determines Optimal Phagosomal Escape and Francisella Pathogenicity Island Protein Expression.
Supplier
In PLoS ONE, 2007
... Fibronectin was purchased from BD Biosciences (Franklin Lakes, NJ) ...
Rac and Rap GTPase activation assays.
Supplier
In PLoS ONE, 2006
... Cytocholasin B (1 µg/ml), nocodazole (10 nM), MTT (0.5 mg/ml), DAPI (1 µg/ml), PMA (100 ng/ml), fibronectin (10 µg/ml), human placenta collagen type VI (10 µg/ml) and rhodamine phalloidin were from Sigma Aldrich (St ...
Regulation of midbrain dopaminergic neuron development by Wnts, Sfrps and bHLH proteins.
Supplier
In PLoS ONE, 2006
... Feeder-free cultures of BG01V2 were grown on human fibronectin, 20 µg/ml, (BD Biosciences, Bedford, U ...
Valproic acid, a histone deacetylase inhibitor, is an antagonist for oncolytic adenoviral gene therapy.
Supplier
In PLoS ONE, 2005
... ng/ml triiodothyronine (Sigma Aldrich), 0.1 mM phosphoetanolamine, 50 ng/ml cholera toxin (Sigma Aldrich), 0.1 µg/ml fibronectin (Sigma Aldrich) and 20 µg/ml fetuin ...
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
Supplier
In Cancer Chemotherapy and Pharmacology, 2005
... Vitronectin and fibronectin were purchased from BD Biosciences (Boston) ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
Supplier
In The Journal of Cell Biology, 2004
... Human fibronectin was from BD Biosciences.
Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration
Supplier
In Oncogene, 2004
... 2000, AlexaF488-labeled secondary antibody, RPMI-1640 and DMEM (Invitrogen); EGF, Matrigel and fibronectin (BD Biosciences); CXCL12 (R&D Systems); and ...
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
Supplier
In PLoS ONE, 2004
... Vimentin (#550513) and fibronectin (#610078) antibodies were products of BD Biosciences (Franklin Lakes, NJ) ...
The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development
Supplier
In The Journal of Cell Biology, 2004
... Anti–E-cadherin and anti-fibronectin mAbs were from Transduction Laboratories, anti-tubulin mAb was from Abcam, goat anti-actin pAb was ...
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
Supplier
In The Journal of Cell Biology, 2004
... Rhodamine-phalloidin was obtained from Invitrogen, and human fibronectin was obtained from BD Biosciences.
Synfire chains and cortical songs: Temporal modules of cortical activity.
Supplier
In PLoS ONE, 2003
... in sterile water, Sigma), laminin (50 µg/mL in Dulbecco's phosphate buffer saline, D-PBS, R&D Systems), fibronectin (50 µg/mL in D-PBS, BD Biosciences), Matrigel (1∶100 v/v in ...
Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement
Supplier
In The Journal of Cell Biology, 2002
... -lysine, and bovine plasma fibronectin were purchased from BD Biosciences and Sigma-Aldrich, respectively ...
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases.
Supplier
In PLoS ONE, 2002
... Fibronectin (BD Biosciences) was freshly prepared from ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome
Supplier
In PLoS Biology, 2002
... Human fibronectin was from BD Biosciences Pharmingen (San Diego, California, ...
The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins
Supplier
In The Journal of Experimental Medicine, 2002
... , FBG and fibronectin (FN) (Sigma-Aldrich), vitamin D3 (BIOMOL Research Laboratories, Inc.), transforming ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Supplier
In Vascular Cell, 2002
... Vitronectin was from Sigma and fibronectin and rat-tail type I collagen was from BD Biosciences.
Efficient expression system of human recombinant laminin-5.
Supplier
In PLoS ONE, 2001
... from EPITOMICS; Affinity purified rabbit anti-rat IgG from Vector Laboratories (Burlingame, CA); Purified human plasma fibronectin from Millipore; rat tail type I collagen from BD Transduction Laboratories; 3,3′-dithiobis[sulfosuccinimidylpropionate] (DTSSP) cross-linker from Thermo Scientific (Rockford, IL); and, Alexa ...
Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
Supplier
In PLoS ONE, 2001
... Rabbit monoclonal antibody to GAPDH, mouse monoclonal antibody to fibronectin, goat anti-mouse IgG and anti-rabbit IgG secondary antibodies were from Santa Cruz Biotechnology, Inc ...
Rho GTPase signalling pathways in the morphological changes associated with apoptosis
Supplier
In Tumour Biology, 2001
... ], Collagen IV, fibronectin and laminin 1 were purchased from Merck Millipore (Danvers, MA) ...
Parathyroid hormone-related protein overexpression in the human colon cancer cell line HT-29 enhances adhesion of the cells to collagen type I
Supplier
In British Journal of Cancer, 2000
... The ECM proteins human fibronectin and mouse laminin-1 (derived from the EHS tumour) were purchased from BD Biosciences (Oxford, UK), whereas collagen ...
Cell senescence and cancer
Supplier
In International Journal of Oral Science, 2000
... Glostrup, Denmark), anti-laminin 1 (1∶60; Sigma Chemical Co.), anti-laminin 5 (1∶300; Chemicon International, Temecula, CA, USA) and anti-fibronectin (1∶400; Dako S/A) ...
Measurement of contractile forces generated by individual fibroblasts on self-standing fiber scaffolds
Supplier
In Biomedical Microdevices, 1999
... suspended fiber scaffolds were dipped in 70% ethanol for sterilization, exposed for coating to 20 μg/mL fibronectin (Sigma Aldrich) in phosphate buffered saline ...
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA
expression in human thymus increases with age and is associated with thymic atrophy
Supplier
In International Journal of Medical Sciences, 1999
... 3T3-L1 preadipocytes were placed in fibronectin-coated plates (BD Biosciences, CA) in DMEM ...
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D
Supplier
In The Journal of Cell Biology, 1999
... Fibronectin was purchased from Becton Dickinson.
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis.
Supplier
In PLoS ONE, 1999
... Matrigel, collagen type I and fibronectin were purchased from BD Biosciences (Bedford, MA, USA) ...
Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility
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In The Journal of Experimental Medicine, 1997
... Cells were harvested 10–18 d after plating and allowed to adhere to fibronectin-coated coverslips (Becton Dickinson) for infection with ...
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis
Supplier
In The Journal of Cell Biology, 1997
... Cell culture reagents and fibronectin were from Life Technologies, ephrinB2/Fc was from Immunex, ...
Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
Supplier
In The Journal of Cell Biology, 1997
... Other reagents used were as follows: human plasma fibronectin (BD Biosciences), PDGF (PDGF-BB), and PMA ...
Functional association between promoter structure and transcript alternative splicing
Supplier
In Nucleic Acids Research, 1996
... Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan ...
Cross-linking of the NH2-terminal region of fibronectin to molecules of large apparent molecular mass
Supplier
In The Journal of Cell Biology, 1995
... (Temecula, CA); anti-fibronectin (3E3), anti-integrin subunits β5 (P1F6), and β1 (P4C10) were purchased from Life Technologies/ ...
Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung
Supplier
In The Journal of Cell Biology, 1994
... Anti-fibronectin antibodies used for immunofluorescence and immunohistochemistry were purchased from Sigma-Aldrich (FN-15) and Santa Cruz Biotechnology, Inc ...
Calcitonin gene-related peptide promotes Schwann cell proliferation.
Supplier
In Journal of Biology, 1994
... The cells were expanded on poly-D-lysine- and fibronectin-coated culture dishes (Falcon; BD Biosciences, Oxford, UK) in 'complete ...
The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism
Supplier
In The Journal of Cell Biology, 1991
... Fibronectin was obtained from Collaborative Biomedical Products (Bedford, MA) and ...
Molecular Proximity of Kv1.3 Voltage-gated Potassium Channels and β1-Integrins on the Plasma Membrane of Melanoma Cells
Supplier
In The Journal of General Physiology, 1990
... Fibronectin was purchased from Life Technologies.
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation.
Supplier
In PLoS ONE, 1987
... with LHC-9 media (Invitrogen, Carlsbad, CA) in a 37°C, 5% CO2 incubator in dishes precoated with fibronectin (BD Biosciences, San Jose, CA), type ...
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
Supplier
In The Journal of Cell Biology, 1980
... Human fibronectin was from BD Biosciences.
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins
Supplier
In The Journal of Cell Biology, 1979
... Fibronectin was from BD Biosciences.
