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Fibroblast growth factor 4

Fibroblast Growth Factor 4, FGF4, hst-1
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Fibroblast Growth Factor 2, int-2, ACID, HAD
Papers on Fibroblast Growth Factor 4
Clinically advanced and metastatic pure mucinous carcinoma of the breast: a comprehensive genomic profiling study.
Stephens et al., Albany, United States. In Breast Cancer Res Treat, Feb 2016
Other frequently altered genes of interest in pmucBC were CCND1 and the FGF3/FGF4/FGF19 amplicon (27 %), often co-amplified together.
MK886 inhibits the pioglitazone-induced anti-invasion of MDA-MB-231 cells is associated with PPARα/γ, FGF4 and 5LOX.
Khoo et al., George Town, Malaysia. In Cytotechnology, Feb 2016
In addition, we correlated the expression of PPARα mRNA with other genes, including PPARγ, FGF4 and 5LOX, in drug-treated MDA-MB-231 cells.
Hepatocellular Carcinoma in Noncirrhotic Liver with Glycogenotic Foci: Basic Science Meets Genomic Medicine.
Kato et al., New York City, United States. In Semin Liver Dis, Nov 2015
Precision genomic analysis of this tumor disclosed five alterations with amplifications of genes CCNE1, FGF3 and FGF4, MYCL1, and ARID1A.
Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: Are we getting there?
Cheng et al., Taipei, Taiwan. In World J Gastroenterol, Oct 2015
These studies identified tumor amplification of FGF3/FGF4 or VEGFA and tumor expression of phospho-Mapk14 and phospho-Atf2 as possible predictive markers that await validation.
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
Zucman-Rossi et al., Paris, France. In Nat Genet, May 2015
Analyses according to tumor stage progression identified TERT promoter mutation as an early event, whereas FGF3, FGF4, FGF19 or CCND1 amplification and TP53 and CDKN2A alterations appeared at more advanced stages in aggressive tumors.
The influence of fibroblast growth factor 4 on hepatogenic capacity of Wharton's jelly mesenchymal stromal cells.
Talaei-Khozani et al., Shīrāz, Iran. In Rom J Morphol Embryol, 2014
The present study aimed to differentiate WJ-MSCs toward hepatocyte-like cells on collagen film in the presence of hepatogenic factors, including fibroblast growth factor 4 (FGF4), hepatocyte growth factor (HGF), and insulin-like growth factor-1 (IGF-1).
Comparison of hepatic nuclear factor-4 expression in two- and three-dimensional culture of Wharton's jelly-derived cells exposed to hepatogenic medium.
Vojdani et al., Shīrāz, Iran. In Rom J Morphol Embryol, 2014
WJ-MSCs were cultured in 2D collagen films and 3D collagen scaffolds in the presence of hepatogenic media with or without pre-treatment with fibroblast growth factor-4 (FGF4) for 21 days.
A jagged road to lymphoma aggressiveness.
Maillard et al., Ann Arbor, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Cao and colleagues identify an FGF4/Jagged1-driven crosstalk between tumor cells and their vascular niche that activates Notch signaling, sustaining the aggressiveness of certain mouse and human B cell lymphomas.
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.
Rafii et al., New York City, United States. In Cancer Cell, 2014
Here, we show that FGF4 produced by B cell lymphoma cells (LCs) through activating FGFR1 upregulates the Notch ligand Jagged1 (Jag1) on neighboring ECs.
Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (Review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2013
Gene or protein therapy delivering VEGF, FGF2 or FGF4, as well as cell therapy using endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs) or induced pluripotent stem cells (iPSCs) have been developed as pro-angiogenic therapeutics for ischemic heart disease and peripheral vascular disease.
The roles of fibroblast growth factors in the testicular development and tumor.
Qu et al., Changchun, China. In J Diabetes Res, 2012
Among 23 members of FGFs, the FGF-1, FGF-2, FGF-4, FGF-8, FGF-9, and FGF-21 were involved and describe in details.
Viral and molecular aspects of oral cancer.
Sand et al., Uppsala, Sweden. In Anticancer Res, 2012
Herein, we review the available literature regarding high-risk factors such as alcohol and tobacco usage; discuss the roles of human papillomaviruses (HPV), the Epstein-Barr virus, and the human herpes simplex virus (HSV); and evaluate several candidate genes associated with the condition: p53, p16(INK4) and p21(WAF1/CIPI), survivin, B-cell lymphoma-2 (BCL-2), keratins, Fibroblast growth factor 3 (FGF3), FGF4, FGF19, Oral cancer overexpressed gene 1 (ORAOV1), and Cyclin D1 (CCND1).
Differential expression of FGF family members in a progestin-dependent BT-474 human breast cancer xenograft model.
Hyder et al., Columbia, United States. In Histol Histopathol, 2012
In vivo stimulation of BT-474 cell growth by progesterone is associated with up-regulation of FGF4 which may promote tumor growth and maintenance.
Common nucleotide sequence of structural gene encoding fibroblast growth factor 4 in eight cattle derived from three breeds.
Kobayashi et al., Akita, Japan. In Anim Sci J, 2012
this is the first determination of the complete nucleotide sequence of the structural gene encoding bovine FGF4 in identified breeds
Fibroblast growth factor receptor 4 regulates proliferation and antiapoptosis during gastric cancer progression.
Shi et al., Shanghai, China. In Cancer, 2012
knockdown of FGFR4 expression led to decreased proliferation and an increased rate of apoptosis in the MKN45 and SGC7901 GC cell lines
Transient and stable transfections of mouse myoblasts with genes coding for pro-angiogenic factors.
Kurpisz et al., Poznań, Poland. In J Physiol Pharmacol, 2011
Myoblasts which overexpress FGF-4 exhibit significant changes in cell cycle and pro-angiogenic potential with only slight differences in the expression of the myogenic genes.
FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis.
Lewandoski et al., Frederick, United States. In Proc Natl Acad Sci U S A, 2011
study provides genetic evidence that FGFs are the wavefront signal and identifies the data show that FGF action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM progenitor tissue
Trophoblast stem cells.
Fisher et al., Columbia, United States. In Biol Reprod, 2011
Mouse TSC self-renewal can be sustained by culture on mitotically inactivated feeder cells, which provide one or more factors related to the NODAL pathway, and a medium supplemented with FGF4, heparin, and fetal bovine serum.
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
Wells et al., Cincinnati, United States. In Nature, 2011
Using this culture system as a model to study human intestinal development, we identified that the combined activity of WNT3A and FGF4 is required for hindgut specification whereas FGF4 alone is sufficient to promote hindgut morphogenesis.
An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs.
Ostrander et al., Bethesda, United States. In Science, 2009
By using a multibreed association analysis in the domestic dog, we demonstrate that expression of a recently acquired retrogene encoding fibroblast growth factor 4 (fgf4) is strongly associated with chondrodysplasia, a short-legged phenotype that defines at least 19 dog breeds including dachshund, corgi, and basset hound.
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