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Fibroblast growth factor 2

Fibroblast Growth Factor 2, bFGF, FGF-2
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, vascular endothelial growth factor, HAD, V1a, Epidermal Growth Factor
Papers using Fibroblast Growth Factor 2 antibodies
Convection-enhanced delivery of methotrexate-loaded maghemite nanoparticles
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Margel Shlomo et al., In International Journal of Nanomedicine, 2010
... fibrinogen, bovine fibronectin, aprotinin, D-glucose and poly-L-lysine (PLL; MW 30,000–70,000) from Sigma (Israel); recombinant human bFGF from PeproTech (Israel); bovine thrombin and factor XIII from Merck (Israel); Midi-MACS magnetic columns ...
Elite and stochastic models for induced pluripotent stem cell generation.
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Verfaillie Catherine M., In PLoS ONE, 2008
... (all Life Technologies), 2 mM glutamine (Hyclone), 0.1 mM β-mercaptoethanol (Millipore), and 10 ng/mL recombinant human bFGF (BD Biosciences)) ...
Contractile smooth muscle cells derived from hair-follicle stem cells.
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Emanueli Costanza, In PLoS ONE, 2007
... Human VEGF165, human PDGF-BB, FGF2 and TGFβ1 were from BioVision (Mountain View, USA) ...
Thyroid hormone stimulates gamma-glutamyl transpeptidase in the developing rat cerebra and in astroglial cultures
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Choi Kang-Yell et al., In BMC Cell Biology, 2004
... NPCs were grown in N2 medium containing bFGF (10 ng/ml), and transfected with 0, 0.5, 1, 2, or 3 µg pEGFP-C1 (Clontech) as described in Methods ...
Generating oocytes and sperm from embryonic stem cells.
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Beier Frank, In PLoS ONE, 2004
... (1∶1) containing penicillin/streptomycin supplemented with 1X B-27 (Gibco), 20 ng/ml EGF (Sigma), and 40 ng/ml bFGF (Cell Signaling Technologies)] ...
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Papers on Fibroblast Growth Factor 2
Mechanisms of fibroblast growth factor signaling in the ovarian follicle.
Review
New
Price, Saint-Hyacinthe, Canada. In J Endocrinol, Feb 2016
Within the female reproductive tract, the effects of FGFs have been focused on the ovary, and the most studied one is FGF2, which stimulates granulosa cell proliferation and decreases differentiation (decreased steroidogenesis).
Apelin: An Endogenous Peptide Essential for Cardiomyogenic Differentiation of Mesenchymal Stem Cells via Activating Extracellular Signal-Regulated Kinase 1/2 and 5.
New
Gao et al., Beijing, China. In Cell Biol Int, Feb 2016
In this research, we used RNA interference methodology and gene transfection technique to regulate the expression of apelin in Wharton's jelly-derived mesenchymal stem cells and induced cells with a effective cardiac differentiation protocol including 5-azacytidine and bFGF.
Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids.
New
Revzin et al., Davis, United States. In Acta Biomater, Feb 2016
Heparin-containing hydrogel particles sequestered growth factors Nodal and FGF-2, which are implicated in specifying pluripotent cells to definitive endoderm.
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
New
Impact
Azim Surani et al., Kōbe, Japan. In Nature, Feb 2016
We investigated this in an in vitro model, in which naive pluripotent embryonic stem (ES) cells cultured in basic fibroblast growth factor (bFGF) and activin A develop as epiblast-like cells (EpiLCs) and gain competence for a PGC-like fate.
FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression.
Review
New
Fuxe et al., Stockholm, Sweden. In Trends Neurosci, Jan 2016
Combined FGF2 and 5-HT1A agonist treatment increased the formation of these heterocomplexes and the facilitatory allosteric receptor-receptor interactions within them led to the enhancement of FGFR1 signaling and was associated with the development of antidepressant effects.
MicroRNA variants as genetic determinants of bone mass.
Review
New
Delany et al., Farmington, United States. In Bone, Jan 2016
SNPs in miRNA targeting sites (miR-TS-SNPs) that alter miRNA binding are described for the bone remodeling genes bone morphogenetic protein receptor 1 (Bmpr1), fibroblast growth factor 2 (Fgf2), osteonectin (Sparc) and histone deacetylase 5 (Hdac5).
Overexpression of protein kinase C ɛ improves retention and survival of transplanted mesenchymal stem cells in rat acute myocardial infarction.
New
Zeng et al., Beijing, China. In Cell Death Dis, Dec 2015
Echocardiographic measurements and histologic studies were performed at 4 weeks after transplantation, and MSC survival, expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor β (TGFβ), cardiac troponin I (cTnI), von Willebrand factor (vWF), smooth muscle actin (SMA) and factor VIII and apoptosis in infarct border zones were assessed.
Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells.
New
Kwan et al., In J Vis Exp, Dec 2015
Starting from dissociated cultures of single iMOP cells, protocols that promote cell cycle exit and differentiation by basic fibroblast growth factor (bFGF) withdrawal were described.
Gleditsia species: An ethnomedical, phytochemical and pharmacological review.
Review
New
Zhang et al., Shanghai, China. In J Ethnopharmacol, Dec 2015
Among these biological studies, the possible mechanisms of antitumor action are stressed in this review, and these include causing cytotoxicity to cancer cells, inhibition of proliferation of cancer cells by affecting their growth, regeneration and apoptosis, inhibition of basic fibroblast growth factor (bFGF) and nitric oxide (NO), modulation of the oncogenic expression and telomerase activity results, inhibition of the expression of pro-angiogenic proteins, as well as down-regulation of intra/extracellular proangiogenic modulators, etc. CONCLUSIONS: On the basis of preliminary research on Gleditsia genus it could be stated that saponins investigations may be more promising in future.
Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage.
New
Impact
Qian et al., Shanghai, China. In Immunity, Oct 2015
Here we show that growth factor FGF2 synergized with interleukin-17 (IL-17) to induce genes for repairing of damaged epithelium.
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
New
Impact
Presta et al., Brescia, Italy. In Cancer Cell, Sep 2015
Using pharmacophore modeling of the interaction of a minimal PTX3-derived FGF-binding pentapeptide with FGF2, we identified a small-molecule chemical (NSC12) that acts as an extracellular FGF trap with significant implications in cancer therapy.
[Research Progress of Klotho].
Review
New
Qi et al., In Sheng Li Ke Xue Jin Zhan, Aug 2015
Klotho, a newly identified anti-aging gene, can be regulated by many factors, such as calcitonin gene-related peptide, fibroblast growth factor 2 could up-regulate Klotho expression; whereas renin-angiotensin system, urinary toxins, inflammation and oxidative stress could reduce expression of Klotho.
Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells.
New
Impact
Li et al., Shanghai, China. In Cell, Jun 2015
Administration of vascular endothelial growth factor (VEGF) activated CD133(+) ependymal neural stem cells (NSCs), lining not only the lateral but also the fourth ventricles and, together with basic fibroblast growth factor (bFGF), elicited subsequent neural lineage differentiation and migration.
Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.
New
Impact
Bell et al., Ottawa, Canada. In Nat Med, May 2015
In turn, CAFs produced high levels of fibroblast growth factor 2 (FGF2), initiating a signaling cascade in cancer cells that reduced retinoic acid-inducible gene I (RIG-I) expression and impeded the ability of malignant cells to detect and respond to virus.
Differential expression of epithelial basement membrane components nidogens and perlecan in corneal stromal cells in vitro.
Wilson et al., São Paulo, Brazil. In Mol Vis, 2014
In agreement with previous studies, serum-free DMEM was found to be optimal for keratocytes, DMEM with 10% serum and 40 ng/ml FGF-2 yielded the best marker profile for corneal fibroblasts, and DMEM with 1% serum and 2 ng/ml TGF-β1 was found to be optimal for myofibroblasts.
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.
GeneRIF
Nickel et al., Heidelberg, Germany. In J Biol Chem, 2012
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.
Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells.
GeneRIF
Wang et al., Athens, United States. In J Biol Chem, 2012
Heparan sulfate is required for embryonic stem cell pluripotency, in particular lineage specification into mesoderm through facilitation of FGF and BMP signaling.
Overexpression of human HMW FGF-2 but not LMW FGF-2 reduces the cytotoxic effect of lentiviral gene transfer in human corneal endothelial cells.
GeneRIF
Lindemann et al., Dresden, Germany. In Invest Ophthalmol Vis Sci, 2012
Transduction with FGF-2 encoding lentiviral vectors resulted in overexpression of the respective isoform in all tested cell populations.
FGF-2 inhibits TNF-α mediated apoptosis through upregulation of Bcl2-A1 and Bcl-xL in ATDC5 cells.
GeneRIF
Choi et al., Ch'ŏngju, South Korea. In Bmb Rep, 2012
A subset of Bcl2 family proteins are the targets of FGF-2 signaling that promotes the survival of ATDC5 cells.
Cytokines in pericardial effusion of patients with inflammatory pericardial disease.
GeneRIF
Pankuweit et al., Marburg an der Lahn, Germany. In Mediators Inflamm, 2011
VEGF and bFGF may participate in the pathogenesis of inflammatory pericardial disease
More papers using Fibroblast Growth Factor 2 antibodies
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1.
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Ushio-Fukai Masuko, In PLoS ONE, 2003
... Rabbit polyclonal anti-fibroblast growth factor-2 (FGF-2) antibody was obtained from Abcam (Cambridge, UK) ...
CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus.
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Chadwick Brian P., In PLoS ONE, 2000
... collagen (Sigma Aldrich; #C9791) in F10 medium (Invitrogen) supplemented with 20% FBS, Pen-Strep, 10 ng bFGF (Invitrogen), and 1 µM dexamethasone (Sigma Aldrich; St ...
Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro.
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Valdivia Raphael H., In PLoS Pathogens, 1998
... shRNA constructs specific for FGF2 or GFP were obtained from OriGene Technology ...
The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development
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Augustin Hellmut G. et al., In The Journal of Cell Biology, 1994
... Neutralizing (type I) and nonneutralizing (type II) monoclonal mouse anti–bovine FGF-2 antibody were purchased from Upstate Biotechnology (Biomol, Hamburg, Germany) and the ...
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
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Carson D.D. et al., In The Journal of Cell Biology, 1990
... recombinant bFGF, TGF-β1, and rabbit antibody to human bFGF, which does not cross-react with mouse bFGF, were all obtained from Becton Dickinson Labware ...
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