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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fibrillarin

Fib, FBL, Fib-1
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, FBL-3, ACID, fibrillin-1
Papers using Fib antibodies
CD8+ T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function
Supplier
Greenberg Philip D. et al., In The Journal of Experimental Medicine, 2000
... Identification and Cloning of Full-Length TCR-α and -β Genes Specific for FBL and FMuLVgag, and Generation of Transgenic Mice.
Papers on Fib
Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation.
New
Lama et al., United States. In J Biol Chem, Feb 2016
Relative to normal MCs (non-Fib MCs), MCs derived from fibrotic human lung allografts (Fib-MCs) demonstrated increased phosphoinositide-3kinase (PI3K) dependent activation of both mTORC1and mTORC2, as measured by increased phosphorylation of S6K1 and 4EBP1 (mTORC1 substrates) and Akt (an mTORC2 substrate).
CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity.
New
Dittmer et al., Essen, Germany. In J Immunol, Feb 2016
In this study, we used the highly immunogenic Friend virus-induced FBL-3 tumor as a model to study the mechanisms of immunological tumor control by CD4(+) T cells in the course of CD137 (4-1BB) agonist immunotherapy in the absence of a CD8 T cell response.
Coating morphology and surface composition of acrylic terpolymers with pendant catechol, OEG and perfluoroalkyl groups in varying ratio and the effect on protein adsorption.
New
Zhang et al., Wuhan, China. In Colloids Surf B Biointerfaces, Jan 2016
The effect on protein adsorption was investigated using bovine serum albumin (BSA) and adhesive fibrinogen (Fib) as model proteins.
Clinically detectable drusen domains in fibulin-5-associated age-related macular degeneration (AMD) : Drusen subdomains in fibulin-5 AMD.
New
Russell et al., Ankara, Turkey. In Int Ophthalmol, Jan 2016
Of seven patients we identified with AMD due to mutations in the fibulin-5 gene (Fib-5 AMD), five had color fundus photography and fluorescein angiography (FA).
HBcrAg during nucleos(t)ide analog therapy are related to intra-hepatic HBV replication and development of hepatocellular carcinoma.
New
Kaneko et al., Kanazawa, Japan. In J Infect Dis, Dec 2015
Multivariate cox regression analysis showed age (>60 years, HR=2.66) and Fib-4 index (>2.1,
A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans.
New
Lo et al., Taiwan. In Plos Genet, Oct 2015
Here, through a series of loss-of-function analyses, we report that the nucleolar size is regulated by a circuitry composed of microRNA let-7, translation repressor NCL-1, and a major nucleolar pre-rRNA processing protein FIB-1/fibrillarin.
[Analysis on factors relevant to operation success rate of internal arteriovenous fistula used in pediatric patients with end stage renal disease].
New
Shen et al., Beijing, China. In Zhonghua Er Ke Za Zhi, Sep 2015
Factors like sex, choice of operation side, choice of operation vessel, anesthesia, urine protein, model of vascular suture line, age of surgery, inner diameter of anastomotic stoma, hemoglobin (Hb), platelet (Plt), hematocrit (Hct), coagulation function (prothrombin time, PT, fibrinogen, Fib, activated partial thromboplastin time, APTT), creatinine (Scr), Ca²⁺, left ventricular ejection fraction (LVEF), blood pressure (before, during and after surgery) were collected retrospectively.
In vitro effects of 3% hypertonic saline and 20% mannitol on canine whole blood coagulation and platelet function.
Howard et al., Bern, Switzerland. In Bmc Vet Res, 2014
Rotational thromboelastometry (ROTEM) was used to assess clotting time (CT), clot formation time (CFT) and maximal clot firmness (MCF) following extrinsic activation (Ex-tem) and after platelet inhibition (Fib-tem).
High yield exogenous protein HPL production in the Bombyx mori silk gland provides novel insight into recombinant expression systems.
Xu et al., Suzhou, China. In Sci Rep, 2014
In the mutants, the transcription level of Fib-L and P25, and corresponding encoding proteins, did not decrease.
p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.
Impact
Diaz et al., Lyon, France. In Cancer Cell, 2013
Here, we show that p53 represses expression of the rRNA methyl-transferase fibrillarin (FBL) by binding directly to FBL. High levels of FBL are accompanied by modifications of the rRNA methylation pattern, impairment of translational fidelity, and an increase of internal ribosome entry site (IRES)-dependent translation initiation of key cancer genes.
The nucleolus of Caenorhabditis elegans.
Review
Lo et al., Taiwan. In J Biomed Biotechnol, 2011
This paper details the advantages of using C. elegans to investigate features of the nucleolus during the organism's development by following dynamic changes in fibrillarin (FIB-1) in the cells of early embryos and aged worms.
Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.
GeneRIF
Takahashi et al., Fuchū, Japan. In Mol Cell Proteomics, 2011
p32 is a new rRNA maturation factor involved in the remodeling from pre-90S particles to pre-40S and pre-60S particles that requires the exchange of FBL for Nop52.
SUV39h-independent association of HP1 beta with fibrillarin-positive nucleolar regions.
GeneRIF
Kozubek et al., Brno, Czech Republic. In Chromosoma, 2010
SUV39h1 associated with HP1 beta in fibrillarin-positive nucleolar regions.
Fibrillarin and Nop56 interact before being co-assembled in box C/D snoRNPs.
GeneRIF
Roussel et al., Paris, France. In Exp Cell Res, 2009
Data demonstrate that fibrillarin and Nop56 directly interact in vivo, and that this interaction is indispensable for the association of both proteins with the box C/D snoRNPs.
Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin.
GeneRIF
Vaughan et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2008
Evidence that BIG1 and nucleolin, but not fibrillarin, can be present with p62 at the nuclear envelope confirms the presence of BIG1 and nucleolin in dynamic molecular complexes that change in composition while moving through nuclei
Fibrillarin, a nucleolar protein, is required for normal nuclear morphology and cellular growth in HeLa cells.
GeneRIF
Fukui et al., Suita, Japan. In Biochem Biophys Res Commun, 2007
Our data suggest that fibrillarin would play a critical role in the maintenance of nuclear shape and cellular growth.
Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo.
Review
Degen et al., Cincinnati, United States. In Exp Biol Med (maywood), 2004
A novel line of mice expressing a mutant form of fibrinogen (Fib gamma(390-396A)) has revealed that gamma chain residues 390-396 are important for the high-affinity engagement of fibrinogen by alpha(M)beta(2) and leukocyte function in vivo.
Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.
Impact
Degen et al., Cincinnati, United States. In Cell, 1996
We generated mice deficient in Plg and fibrinogen (Fib) and show that removal of fibrin(ogen) from the extracellular environment alleviates the diverse spontaneous pathologies previously associated with Plg deficiency and corrects healing times.
Amyloid fibril toxicity in Alzheimer's disease and diabetes.
Review
Yankner et al., Boston, United States. In Ann N Y Acad Sci, 1996
In the AD brain, diffuse plaques composed mostly of amorphous beta amyloid (Am-beta A) are inert, whereas compact plaques composed of beta amyloid fibrils (Fib-beta A) are associated with neurodegenerative changes.
The role of B cells for in vivo T cell responses to a Friend virus-induced leukemia.
Impact
Greenberg et al., Seattle, United States. In Science, 1990
This study evaluated the role of B cells in the induction of protective T cell immunity to a Friend murine leukemia virus (F-MuLV)-induced leukemia (FBL).
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