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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Four and a half LIM domains 2

FHL2, DRAL
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: LIM, LIM-only, CAN, HAD, Perforin
Papers using FHL2 antibodies
The LIM-only protein FHL2 interacts with β-catenin and promotes differentiation of mouse myoblasts
Supplier
Wixler Viktor et al., In The Journal of Cell Biology, 1999
... For expression in mammalian cells, the cDNA fragment coding for aa 3–279 of murine FHL2 was cloned into the pcDNA3.1/His
MOLMOL: A program for display and analysis of macromolecular structures
Supplier
Zhang Yang, In PLoS ONE, 1995
... WT TC5b, P12W-TC5b, and W6G-TC5b, was synthesised by GeneArt (Regensburg, Germany) and ligated into the Dral and Xhol restriction sites of the pET41a vector (Merck Chemicals Ltd., Nottingham, UK) ...
Papers on FHL2
Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease.
Review
New
de Vries et al., Amsterdam, Netherlands. In Biochim Biophys Acta, Feb 2016
FHL2 belongs to the LIM-domain only proteins and contains four and a half LIM domains, each of which are composed of two zinc finger structures.
Four and a half LIM domains 2 contributes to the development of human tongue squamous cell carcinoma.
New
Xu et al., Jinan, China. In J Mol Histol, Feb 2016
UNASSIGNED: Four and a half LIM domains 2 (FHL2) is a protein of 279 amino acids in length containing four full LIM-domains and a half LIM-domain at the amino terminus.
FHL2 mediates tooth development and human dental pulp cell differentiation into odontoblasts, partially by interacting with Runx2.
New
Wang et al., Jinan, China. In J Mol Histol, Feb 2016
Our previous study demonstrated that four and a half LIM domains 2 (FHL2) may play an important role in tooth development and human dental pulp cell differentiation.
Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry.
New
Aricò et al., Florence, Italy. In J Allergy Clin Immunol, Jan 2016
Taken together, mutations of the genes PRF1 (FHL2) and UNC13D (FHL3) accounted for 70% of cases of FHL.
FHL2: a scaffold protein of carcinogenesis, tumour-stroma interactions and treatment response.
Review
New
Demetter et al., Brussels, Belgium. In Histol Histopathol, Jan 2016
UNASSIGNED: Four-and-a-half LIM-domain protein 2 (FHL2) is a multifunctional scaffolding protein regulating signalling cascades and gene transcription.
Search for the potential "second-hit" mechanism underlying the onset of familial hemophagocytic lymphohistiocytosis type 2 by whole-exome sequencing analysis.
New
Zhou et al., Wuhan, China. In Transl Res, Jan 2016
UNASSIGNED: Familial hemophagocytic lymphohistiocytosis type 2 (FHL2), caused by perforin 1 (PRF1), is a genetic disorder of lymphocyte cytotoxicity that usually presents in the first 2 years of life and has a poor prognosis.
Inferring chronological age from DNA methylation patterns of human teeth.
New
Luiselli et al., Bologna, Italy. In Am J Phys Anthropol, Jan 2016
METHODS: We used MALDI-TOF mass spectrometry to analyze DNA methylation levels of specific CpGs located in the ELOVL2, FHL2, and PENK genes.
The FHL2 regulation in the transcriptional circuitry of human cancers.
Review
New
Tsui et al., Hong Kong, Hong Kong. In Gene, Dec 2015
Five members have been categorized into the FHL subfamily, which are FHL1, FHL2, FHL3, FHL4 and activator of CREM in testis (ACT) in human.
Identification of novel therapeutic target genes in acquired lapatinib-resistant breast cancer by integrative meta-analysis.
New
Kim et al., Seoul, South Korea. In Tumour Biol, Oct 2015
By integrative analysis of two systemic networks, we condensed the total number of DEGs to six common genes (LGALS1, PRSS23, PTRF, FHL2, TOB1, and SOCS2).
Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage.
Mar et al., Yokohama, Japan. In Plos One, 2014
Many of these stimulus-specific promoters mapped to key regulators of the ERK (extracellular signal-regulated kinases) signaling pathway such as FHL2 (four and a half LIM domains 2).
Integrated network model provides new insights into castration-resistant prostate cancer.
Zou et al., Nanning, China. In Sci Rep, 2014
We used several public datasets as well as FHL2 overexpression to verify our finding.
CYP2E1 polymorphisms and colorectal cancer risk: a HuGE systematic review and meta-analysis.
Review
Cheng et al., Neijiang, China. In Tumour Biol, 2013
We conducted a meta-analysis to assess the association between CYP2E1 gene Rsa I/Pst I, Dral T/A and 96-bp insertion polymorphisms and CRC susceptibility.
Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro.
Review
Handschel et al., In Stem Cell Res Ther, 2012
We conclude that Dex induces Runx2 expression by FHL2/β-catenin-mediated transcriptional activation and that Dex enhances Runx2 activity by upregulation of TAZ and MKP1.
The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-κB pathway in muscle cells.
GeneRIF
Tsui et al., Hong Kong, Hong Kong. In Cytokine, 2012
FHL2-mediated induction of IL-6 was regulated by the activation of IL-6 promoter through stimulating NF-kappaB and p38 MAPK signaling pathway.
The adaptor protein FHL2 enhances the cellular innate immune response to influenza A virus infection.
GeneRIF
Wixler et al., Münster, Germany. In Cell Microbiol, 2012
On influenza A virus infection FHL2 translocates into the nucleus, potentiating the IRF-3-dependent transcription of the IFNbeta gene.
Bioinformatics analysis of proteomic profiles during the process of anti-Thy1 nephritis.
GeneRIF
Chen et al., Beijing, China. In Mol Cell Proteomics, 2012
FHL2 overexpression induced mesangial cell proliferation by increasing the number of S-phase cells and decreasing G2/M-phase cells, whereas inhibiting FHL2 had the opposite effect
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
GeneRIF
Semenza et al., Baltimore, United States. In J Biol Chem, 2012
FHL2 directly interacts with HIF-1alpha to repress transcriptional activity.
FHL2 protein is a novel co-repressor of nuclear receptor Nur77.
GeneRIF
de Vries et al., Amsterdam, Netherlands. In J Biol Chem, 2012
association of FHL2 with Nur77 plays a pivotal role in vascular disease.
The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex.
Impact
GeneRIF
Mehlen et al., Lyon, France. In Nat Cell Biol, 2009
Data suggest that in the absence of its ligand Shh the dependence receptor Patched serves as the anchor for a caspase-activating complex that includes DRAL, and caspase-9.
Nuclear signalling by tumour-associated antigen EpCAM.
Impact
Gires et al., München, Germany. In Nat Cell Biol, 2009
Released EpICD associates with FHL2, beta-catenin and Lef-1 to form a nuclear complex that contacts DNA at Lef-1 consensus sites, induces gene transcription and is oncogenic in immunodeficient mice.
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