WWOX, large common fragile site genes, and cancer.
Rochester, United States. In Exp Biol Med (maywood), Mar 2015
Two other highly unstable CFSs, FRA3B (3p14.2) and FRA6E (6q26), also span extremely large genes, FHIT and PARK2, respectively, and these two genes are also found to be important tumor suppressors.
Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers.
Edinburgh, United Kingdom. In Plos One, 2014
Frequently gained regions contained EGFR, PIK3CA, MYC, SMO, TRIB1, FZD1, and BRCA2, while frequently lost regions contained FHIT and MACROD2.
DNA methylation-based biomarkers in bladder cancer.
Rotterdam, Netherlands. In Nat Rev Urol, 2013
Indeed, several studies have revealed that methylated genes--including CDH1, FHIT, LAMC2, RASSF1A, TIMP3, SFRP1, SOX9, PMF1 and RUNX3--are associated with poor survival in patients with MIBC.
The DNA sequence, annotation and analysis of human chromosome 3.
Houston, United States. In Nature, 2006
It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B.
Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer.
Seoul, South Korea. In J Clin Oncol, 2004
Aberrant methylation at the promoters of the p16, Ras association domain family 1A (RASSF1A), fragile histidine triad (FHIT), H-cadherin, and retinoic acid receptor beta (RARbeta) genes were evaluated in the resected tumor tissues and bronchial lavage samples of NSCLC patients and in the bronchial lavage samples of cancer-free subjects by methylation-specific polymerase chain reaction.