gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Gardner-Rasheed feline sarcoma viral

Fgr, p55c-fgr, p58c-fgr
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Src, Lyn, Hck, alpha-Synuclein, CAN
Papers using Fgr antibodies
Papers on Fgr
Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.
Berton et al., Verona, Italy. In J Immunol, Dec 2015
We found that ectopically expressed Abl or the Src kinase Fgr phosphorylate Sos1, and the Src kinases Hck and Fgr are required for Abl and Sos1 phosphorylation and Abl/Sos1 interaction in macrophages.
The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.
Berton et al., Verona, Italy. In J Immunol, Oct 2015
We report that Hck- and Fgr-deficient mice show a profound impairment in early recruitment of neutrophils and monocytes in response to bacterial LPS.
The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils.
Tseng et al., Taiwan. In Chem Biol Interact, Aug 2015
On the other hand, fMLP-induced phosphorylation of Hck, Fgr kinase activity (other members of Src kinase), downstream phosphorylation of Vav1 and extracellular signal-regulated kinase remained unaffected.
[Mechanism of expression of the Src family kinases (Fgr, Hck, Lyn) and SSeCKS in non-alcoholic steatohepatitis].
He et al., Nantong, China. In Zhonghua Gan Zang Bing Za Zhi, May 2015
OBJECTIVE: To investigate the role of Src family kinases (Fgr, Hck, Lyn) and the major protein kinase C substrate SSeCKS in non-alcoholic steatohepatitis (NASH) and determine the possible mechanism regulating differential expression.
Extracellular peptidases of the cereal pathogen Fusarium graminearum.
Anderson et al., Melbourne, Australia. In Front Plant Sci, 2014
The plant pathogenic fungus Fusarium graminearum (Fgr) creates economic and health risks in cereals agriculture.
6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells.
Yen et al., Ithaca, United States. In Plos One, 2014
Moreover, FICZ augments the expression of a number of the members of the RA-induced signalsome, such as c-Cbl, Vav1, Slp76, PI3K, and the Src family kinases Fgr and Lyn.
ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.
Enríquez et al., Madrid, Spain. In Cell Metab, 2014
This phosphorylation is mediated by the tyrosine-kinase Fgr, which is activated by hydrogen peroxide.
Molecular editing of cellular responses by the high-affinity receptor for IgE.
Rivera et al., Bethesda, United States. In Science, 2014
Low-affinity stimulation increased receptor association with the Src family kinase Fgr and shifted signals from the adapter LAT1 to the related adapter LAT2.
Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.
Weiss et al., San Francisco, United States. In Immunity, 2011
Moreover, our results suggest that CD45 and CD148 preferentially target different SFK members (Hck and Fgr versus Lyn, respectively) to positively and negatively regulate GPCR pathways.
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Choi et al., Ch'ŏngju, South Korea. In J Immunol, 2011
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Functional roles of Src and Fgr in ovarian carcinoma.
Sood et al., Houston, United States. In Clin Cancer Res, 2011
Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target
IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
Steele et al., Birmingham, United States. In J Immunol, 2011
Despite possessing enhanced killing, alveolar macrophage Fgr/Hck/Lyn-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.
Ley et al., Charlottesville, United States. In J Exp Med, 2008
Data show that a pathway involving Fgr, DAP12 and FcRgamma is involved in the initial signaling events downstream of E-selectin-engaged PSGL-1 that are required to initiate neutrophil slow rolling.
[Src kinases in the process of maturation megakryocyte progenitors].
Bany-Łaszewicz et al., Warsaw, Poland. In Postepy Biochem, 2007
Src family protein tyrosine kinases play key roles in cell morphology, proliferation, motility, and survival in megakaryocytopoiesis. Six of Src family kinases (Fyn, Lyn, Fgr, Hck, Src and Yes), are present in megakaryocytes (Mks).
Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor.
Bain et al., Denver, United States. In Biochemistry, 2007
Recruitment of the coactivator, SRC2, is coupled to cooperative DNA binding by the progesterone receptor.
The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
Lowell et al., San Francisco, United States. In Immunity, 2005
Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia.
Li et al., Bar Harbor, United States. In Nat Genet, 2004
Here, we show that Bcr-Abl activated the Src kinases Lyn, Hck and Fgr in B-lymphoid cells.
Tyrosine kinase inhibitors: a new approach for asthma.
Leong et al., Singapore, Singapore. In Biochim Biophys Acta, 2004
Activation of chemokine receptors can trigger JAK-STAT pathway, Lck, Fyn, Lyn, Fgr, and Syk/Zap-70 to induce chemotaxis of inflammatory cells.
Integrin signal transduction in myeloid leukocytes.
Berton et al., San Francisco, United States. In J Leukoc Biol, 1999
These studies have demonstrated that these kinases (Hck, Fgr, and Lyn) are not required for myeloid cell development or for many of the functional properties of myeloid cells but are critical in controlling integrin-mediated signaling events.
The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages.
Brickell et al., London, United Kingdom. In Pathobiology, 1990
The c-fgr proto-oncogene, which is a member of the c-src gene family, encodes the cytoplasmic tyrosine kinase p55c-fgr.
share on facebooktweetadd +1mail to friends