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FGGY carbohydrate kinase domain containing

FGGY
This gene encodes a member of the FGGY kinase family which acts as a phosphotransferase. Some GWAS studies have found an association with amyotrophic lateral sclerosis patients, yet other GWAS studies have not found any association. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: SET, CAN, ACID, HAD, CYP2J2
Papers on FGGY
Expression of AKR1C3 and CNN3 as markers for detection of lymph node metastases in colorectal cancer.
New
Kido et al., Kōbe, Japan. In Clin Exp Med, Aug 2015
The aim of the study was to identify a set of discriminating genes that could be used for the prediction of Lymph node (LN) metastasis in human colorectal cancer (CRC), and for this, we compared the whole genome profiles of two CRC cell lines (the primary cell line SW480 and its LN metastatic variant, SW620) and identified eight genes [S100 calcium-binding protein P; aldo-keto reductase family 1(AKR1), member B1 (aldose reductase; AKR1B1); AKR1, member C3 (AKR1C3); calponin 3, acidic; metastasis associated in colon cancer 1; hemoglobin, epsilon 1; trefoil factor 3; and FGGY carbohydrate kinase domain containing].
Single-nucleotide polymorphism rs6690993 in FGGY is not associated with amyotrophic lateral sclerosisin a large Chinese cohort.
Fan et al., Beijing, China. In Neurobiol Aging, 2014
The single-nucleotide polymorphisms (SNPs) rs6700125 and rs6690993 in FGGY (FLJ10986) were recently reported to be a susceptibility factor for sporadic amyotrophic lateral sclerosis (SALS) in Caucasian populations in genome-wide association studies.
Genome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus).
Ferraz et al., Pirassununga, Brazil. In J Anim Breed Genet, 2014
Important genes such as PDE4B, LEPR, CYP2J2 and FGGY are located near this region, which is overlapped by 12 quantitative trait locus (QTLs) described for several production traits.
Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling Pathways.
Nelson et al., Los Angeles, United States. In Front Psychiatry, 2012
Exome sequencing identified very rare, heterozygous, and likely protein-damaging variants in eight brain-expressed genes: IQUB, JMJD1C, GADD45A, GOLGB1, PLSCR5, VRK2, MESDC2, and FGGY.
Diversity and versatility of the Thermotoga maritima sugar kinome.
Rodionov et al., Los Angeles, United States. In J Bacteriol, 2012
Substrate preferences of 14 kinases mainly from the FGGY and PfkB families were inferred by bioinformatics analysis and biochemically characterized by screening with a panel of 45 different carbohydrates.
The FGGY carbohydrate kinase family: insights into the evolution of functional specificities.
Godzik et al., Los Angeles, United States. In Plos Comput Biol, 2011
Here, using the FGGY carbohydrate kinase family as an example, we built a confidently annotated reference set (CARS) of proteins by propagating experimentally verified functional assignments to a limited number of homologous proteins that are supported by their genomic and functional contexts.
No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort.
GeneRIF
Gasser et al., Tübingen, Germany. In Neurobiol Aging, 2011
The result of this study suggested that FLJI0986 that do not modulate the risk for SALS in the German population.
Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosis.
GeneRIF
Rouleau et al., Montréal, Canada. In Amyotroph Lateral Scler, 2010
This study indicated that mutations in fggy genes are unlikely to be a common cause of ALS in the French and French Canadian populations.
Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis.
GeneRIF
Van Den Berg et al., Utrecht, Netherlands. In Amyotroph Lateral Scler, 2009
Results suggest that common genetic variation in FGGY is not associated with susceptibility to sporadic ALS in genetically homogeneous populations from northern Europe.
Whole-genome analysis of sporadic amyotrophic lateral sclerosis.
Impact
GeneRIF
Stephan et al., Phoenix, United States. In N Engl J Med, 2007
Variants of FLJ10986 may confer susceptibility to sporadic ALS (amyotrophic lateral sclerosis).
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