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Fibroblast growth factor 6

FGF6, Hst2, Fibroblast Growth Factor 6
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Fibroblast Growth Factor 2, Fibroblast Growth Factor 4, FGF-5, int-2, CAN
Papers on FGF6
Expression of FGFs during early mouse tongue development.
Klein et al., San Francisco, United States. In Gene Expr Patterns, Jan 2016
During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme.
Xenograft of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly as a Potential Therapy for Rat Pilocarpine-Induced Epilepsy.
Lin et al., Taipei, Taiwan. In Brain Behav Immun, Jan 2016
Implanted HUMSCs survived in the hippocampus and released cytokines, including FGF-6, amphiregulin, glucocorticoid-induced tumor necrosis factors receptor (GITR), MIP-3β, and osteoprotegerin.
A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae.
Basrai et al., In G3 (bethesda), Jan 2016
Subsequent studies led to the identification of four yeast SIR2 homologs HST1, HST2, HST3, and HST4.
Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy.
Casciari et al., Wichita, United States. In Med Sci Monit, Dec 2015
Cytokines that were most consistently elevated prior to treatments included M-CSF-R, Leptin, EGF, FGF-6, TNF-α, β, TARC, MCP-1,4, MIP, IL-4, 10, IL-4, and TGF-β.
Expression of DMP1 in the developing mouse tongue embryo.
Sato et al., Tokyo, Japan. In Ann Anat, Jul 2015
We also detected the mRNA abundance of tongue morphogenesis markers such as FGF6, TGF-β1, Collagen I, osteocalcin, chondromodulin 1, tenomodulin, Vascular endothelial growth factor (VEGF), caspase-3, and Aifm from embryonic stages by real-time RT-PCR.
Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation.
Thake et al., London, United Kingdom. In Biomed Res Int, 2014
Basal mHSP72 remained elevated before HST2 for the STHA group (P < 0.05) and was unchanged from HST1 in CON (P > 0.05).
Development of a Cadaveric Model for Arthrocentesis.
Johnson et al., In J Vet Med Educ, 2014
Both models had statistically significantly higher yield compared with the unmodified cadaver in all joints at T1 and T2 (p<.05) with the exception of HST2 carpus.
HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors.
Fernig et al., Luxembourg, Luxembourg. In Peerj, 2014
Moreover, whereas FGF6, FGF8, FGF16, FGF17, FGF20 and FGF22 were only expressed as insoluble proteins, their N-terminal HaloTag fusion counterparts (Halo-FGFs) were soluble, and could be successfully purified.
Myogenic-specific ablation of Fgfr1 impairs FGF2-mediated proliferation of satellite cells at the myofiber niche but does not abolish the capacity for muscle regeneration.
Stuelsatz et al., Seattle, United States. In Front Aging Neurosci, 2014
Of the several FGFs shown to affect SCs, FGF1, FGF2, and FGF6 proteins have been documented in adult skeletal muscle.
Human papillomavirus type 8 E6 oncoprotein inhibits transcription of the PDZ protein syntenin-2.
Akgül et al., Köln, Germany. In J Virol, 2012
These results identified syntenin-2 as the first PDZ domain protein controlled by HPV8 and HPV16 at the mRNA level.
Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2.
Wolberger et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2012
Data show that Sir2, and not Hst2, regulates the acetylation state of H3 lysine 79.
Eccentric stimulation reveals an involvement of FGF6 in muscle resistance to mechanical stress.
Chanoine et al., Paris, France. In Eur J Appl Physiol, 2011
A crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress.
Regulation of osteoblast and osteoclast functions by FGF-6.
Cannas et al., Novara, Italy. In J Cell Physiol, 2010
These data demonstrate that FGF-6 may be considered a regulator of bone metabolism as shown by its activity on both osteoblasts and osteoclasts.
Cancer genomics and genetics of FGFR2 (Review).
Katoh, Tokyo, Japan. In Int J Oncol, 2008
FGFR2b is a high affinity receptor for FGF1, FGF3, FGF7, FGF10 and FGF22, while FGFR2c for FGF1, FGF2, FGF4, FGF6, FGF9, FGF16 and FGF20.
Aberrant fibroblast growth factor receptor signaling in bladder and other cancers.
Williams et al., Australia. In Differentiation, 2007
Examples include the overexpression of FGF2 and FGF6 in prostate cancer, and FGF8 overexpression in breast and prostate cancers.
Sprouty gene expression is regulated by nerve and FGF6 during regeneration of mouse muscles.
Chanoine et al., Paris, France. In Growth Factors, 2007
Rescue experiments supported the idea of a specific relationship between FGF6 and Spry 2, both being known for their particular involvement in myogenesis.
FGF6 in myogenesis.
Chanoine et al., Utrecht, Netherlands. In Biochim Biophys Acta, 2006
Involvement of FGF6 in myogenesis. Review.
HST2 mediates SIR2-independent life-span extension by calorie restriction.
Sinclair et al., Boston, United States. In Science, 2005
results show that HST2 is responsible for Sir2-independent life-span extension by calorie restriction and that it does so by suppressing rDNA recombination, the same mechanism by which SIR2 extends life span
The role of fibroblast growth factors and their receptors in prostate cancer.
Ittmann et al., Houston, United States. In Endocr Relat Cancer, 2004
Fibroblast growth factors (FGFs), including FGF1 (acidic FGF), FGF2 (basic FGF), FGF6 and FGF8 are all expressed at increased levels in prostate cancer as paracrine and/or autocrine growth factors for the prostate cancer cells.
Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans.
Guimond et al., Birmingham, United Kingdom. In Biochem Soc Trans, 2003
We also describe evidence that a Caenorhabditis elegans orthologue of the mammalian 2OST enzyme, called HST-2, is essential for the normal development of this nematode.
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