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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fibroblast growth factor 22

FGF22, Fibroblast growth factor 22
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: keratinocyte growth factor, Fibroblast Growth Factor 10, Fibroblast Growth Factor 2, int-2, Fibroblast Growth Factor 4
Papers on FGF22
Presynaptic size of associational/commissural CA3 synapses is controlled by fibroblast growth factor 22 in adult mice.
New
Schikorski et al., Bayamón, Puerto Rico. In Hippocampus, Feb 2016
We quantified the fine structure of excitatory synapses in the stratum radiatum of the CA3d area in adult wild type (WT) and fibroblast growth factor 22 knock-out (FGF22KO) mice by using serial 3D electron microscopy.
Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus).
New
Wang et al., Beijing, China. In Environ Pollut, Jan 2016
Nonetheless, this OPFR exhibited widespread effects on the neurotrophic factors and their receptors (e.g., ntf3, ntrk1, ntrk2, ngfr, and fgf2, fgf11, fgf22, fgfr4), indicating that TDCPP or other OPFRs may elicit neurological effects by targeting neurotrophic factors and their receptors in Chinese rare minnow.
FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number.
New
Ma et al., Zhenjiang, China. In Hear Res, Jan 2016
Roles of fibroblast growth factor 22 (FGF22) on synapse formation were explored under gentamycin ototoxicity.
Screening of candidate genes in fibroblasts derived from patients with Dupuytren's contracture using bioinformatics analysis.
New
Wei et al., Changchun, China. In Rheumatol Int, Aug 2015
In addition, NTF3 was significantly enriched in MAPK signaling pathway, in which other DEGs, such as nuclear receptor subfamily 4, group A, member 1 (NR4A1), fibroblast growth factor 22 (FGF22) and BDNF, were enriched.
Evidence that fibroblast growth factor 10 plays a role in follicle selection in cattle.
New
Buratini et al., In Reprod Fertil Dev, Aug 2015
Theca cells of the future dominant follicle contained less mRNA encoding FGF7 and FGF10 compared with those from the future subordinate follicle 2.5 days after ovulation, before a significant difference between the diameters of the future dominant and future subordinate follicles could be observed, but FGF22 mRNA levels did not change.
Instability restricts signaling of multiple fibroblast growth factors.
New
Krejci et al., Brno, Czech Republic. In Cell Mol Life Sci, Jun 2015
We report that FGF1, FGF3, FGF4, FGF6, FGF8, FGF9, FGF10, FGF16, FGF17, FGF18, FGF20, and FGF22 exist as unstable proteins, which are rapidly degraded in cell cultivation media.
Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis.
New
Umemori et al., Ann Arbor, United States. In Development, Jun 2015
In the hippocampus, the structure crucial for learning and memory, fibroblast growth factor 22 (FGF22) and FGF7 specifically promote excitatory or inhibitory synapse formation, respectively.
FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord.
New
Bareyre et al., München, Germany. In Embo J, Jun 2015
Here, we identify FGF22 as a key regulator of circuit remodeling in the injured spinal cord.
Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7.
New
Umemori et al., Ann Arbor, United States. In J Cell Sci, Feb 2015
Fibroblast growth factor 22 (FGF22) and FGF7 are postsynaptic-cell-derived presynaptic organizers necessary for excitatory and inhibitory presynaptic differentiation, respectively, in the hippocampus.
HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors.
Fernig et al., Luxembourg, Luxembourg. In Peerj, 2014
Moreover, whereas FGF6, FGF8, FGF16, FGF17, FGF20 and FGF22 were only expressed as insoluble proteins, their N-terminal HaloTag fusion counterparts (Halo-FGFs) were soluble, and could be successfully purified.
Distinct FGFs promote differentiation of excitatory and inhibitory synapses.
Impact
GeneRIF
Umemori et al., Ann Arbor, United States. In Nature, 2010
two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
Cancer genomics and genetics of FGFR2 (Review).
Review
Katoh, Tokyo, Japan. In Int J Oncol, 2008
FGFR2b is a high affinity receptor for FGF1, FGF3, FGF7, FGF10 and FGF22, while FGFR2c for FGF1, FGF2, FGF4, FGF6, FGF9, FGF16 and FGF20.
Seeking long-term relationship: axon and target communicate to organize synaptic differentiation.
Review
Umemori et al., Cambridge, United States. In J Neurochem, 2006
Specifically, WNT-7a, neuroligin, synaptic cell adhesion molecule (SynCAM) and fibroblast growth factor-22 (FGF-22) have all been identified as target-derived presynaptic organizers, whereas axon-derived neuronal activity regulated pentraxin (Narp), ephrinB and neurexin reciprocally co-ordinate postsynaptic differentiation.
Progress from the postsynaptic side: signaling in synaptic differentiation.
Review
Biederer, New Haven, United States. In Sci Stke, 2005
In addition, soluble molecules are released from target neurons and initiate presynaptic differentiation, as demonstrated for the fibroblast growth factor FGF-22.
FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.
Impact
GeneRIF
Sanes et al., Saint Louis, United States. In Cell, 2004
FGF22 is expressed by cerebellar granule cells during the period when they receive synapses. Its receptor, FGFR2, is expressed by pontine neurons when they are making synapses on granule cells.
Fibroblast growth factor 22 and its potential role during skin development and repair.
GeneRIF
Grose et al., Zürich, Switzerland. In Exp Cell Res, 2003
Fgf22 has a potential role in cutaneous development and repair.
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