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Fibroblast growth factor 19

FGF19, Fgf15, fibroblast growth factor 19, fibroblast growth factor 15
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, beta 2-adrenoceptor, FGFR4, Cholesterol 7-alpha-Hydroxylase, FGF21
Papers on FGF19
Clinically advanced and metastatic pure mucinous carcinoma of the breast: a comprehensive genomic profiling study.
New
Stephens et al., Albany, United States. In Breast Cancer Res Treat, Feb 2016
Other frequently altered genes of interest in pmucBC were CCND1 and the FGF3/FGF4/FGF19 amplicon (27 %), often co-amplified together.
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.
Review
New
Impact
Moschetta et al., Bari, Italy. In Nat Rev Drug Discov, Jan 2016
The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting.
Expression of FGFs during early mouse tongue development.
New
Klein et al., San Francisco, United States. In Gene Expr Patterns, Jan 2016
During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme.
Dietary procyanidins selectively modulate intestinal farnesoid X receptor-regulated gene expression to alter enterohepatic bile acid recirculation: elucidation of a novel mechanism to reduce triglyceridemia.
New
Ricketts et al., Reno, United States. In Mol Nutr Food Res, Jan 2016
This correlates with increased fecal BA output, decreased serum triglyceride and cholesterol levels, increased hepatic cholesterol 7α-hydroxylase (Cyp7a1), and decreased intestinal fibroblast growth factor 15 (Fgf15) expression.
Farnesoid X receptor-dependent and -independent pathways mediate the transcriptional control of human fibroblast growth factor 19 by vitamin A.
New
Geier et al., Würzburg, Germany. In Biochim Biophys Acta, Jan 2016
UNASSIGNED: Fibroblast growth factor 19 (FGF19) is a gut-derived hormone that controls bile acid (BA), carbohydrate and lipid metabolism.
Interleukin (IL)-1β inhibits β-Klotho expression and FGF19 signaling in hepatocytes.
New
Xia et al., Hong Kong, Hong Kong. In Am J Physiol Endocrinol Metab, Jan 2016
UNASSIGNED: Fibroblast growth factor (FGF) 19 is a member of the FGF15/19 subfamily of FGFs that includes FGF15/19, FGF21 and FGF23.
Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes.
New
Navarro González et al., Santa Cruz de Tenerife, Spain. In Cytokine Growth Factor Rev, Jan 2016
More specifically, FGF19 and FGF21 signaling pathways have been linked to different glucose metabolic processes, including hepatic glucose synthesis, glycogen synthesis, glucose uptake, and insulin sensitivity, among others, and these molecules have been further related to the pathophysiology of diabetes mellitus.
Metabolic roles of endocrine fibroblast growth factors.
Review
New
Owen et al., London, United Kingdom. In Curr Opin Pharmacol, Dec 2015
These three proteins (FGF15/19, FGF21 and FGF23) act in a tissue-specific manner through a membrane-complex consisting of an FGF-receptor and α/βKlotho.
Physiological adaptations following Roux-en-Y gastric bypass and the identification of targets for bariatric mimetic pharmacotherapy.
Review
New
Le Roux et al., Dublin, Ireland. In Curr Opin Pharmacol, Dec 2015
These are (1) exaggerated post-prandial gut hormone responses; (2) local increases in undiluted bile in the gut lumen and augmented circulating bile acid and FGF19 concentrations and (3) compositional changes in the gut microbiota.
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.
Review
New
Potthoff et al., Iowa City, United States. In Semin Cell Dev Biol, Oct 2015
UNASSIGNED: The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability.
Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry.
New
Impact
Mangelsdorf et al., Dallas, United States. In Cell Metab, Jul 2015
Fibroblast growth factor 15 (FGF15) has been proposed as a postprandial hormone that signals from intestine to liver to regulate bile acid and carbohydrate homeostasis.
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
New
Impact
Zucman-Rossi et al., Paris, France. In Nat Genet, May 2015
Analyses according to tumor stage progression identified TERT promoter mutation as an early event, whereas FGF3, FGF4, FGF19 or CCND1 amplification and TP53 and CDKN2A alterations appeared at more advanced stages in aggressive tumors.
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
New
Impact
Evans et al., Los Angeles, United States. In Nat Med, Feb 2015
By mimicking this tissue-selective effect, the gut-restricted FXR agonist fexaramine (Fex) robustly induces enteric fibroblast growth factor 15 (FGF15), leading to alterations in BA composition, but does so without activating FXR target genes in the liver.
Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy.
Review
Konishi et al., Kyoto, Japan. In Front Endocrinol (lausanne), 2014
In contrast, endocrine FGFs, comprising FGF19, FGF21, and FGF23, require α-Klotho or β-Klotho as a cofactor for FGFRs.
Another Shp on the horizon for bile acids.
Impact
Schoonjans et al., Lausanne, Switzerland. In Cell Metab, 2014
In this issue, research from the Feng lab reports Shp2 as a novel integrator of hepatic bile acid and FGF15/FGF19 signaling, adding another layer of complexity to the control of bile acid biosynthesis.
Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19.
GeneRIF
Yamazoe et al., Sendai, Japan. In J Steroid Biochem Mol Biol, 2012
These results suggest that FGF19 is transcriptionally activated through multiple Farnesoid X receptor-responsive elements in the promoter region
FGF19 signaling cascade suppresses APOA gene expression.
GeneRIF
Kostner et al., Graz, Austria. In Arterioscler Thromb Vasc Biol, 2012
The FGF19 effect on APOA was attenuated by transfection of primary hepatocytes with siRNA against the FGF19 receptor 4 (FGFR4).
Physiology of FGF15/19.
Review
GeneRIF
Jones, United States. In Adv Exp Med Biol, 2011
Mouse Fgf15 and human FGF19 play key roles in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis
Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.
GeneRIF
Luo et al., Houston, United States. In Plos One, 2011
Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.
Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism.
GeneRIF
Li et al., San Francisco, United States. In Plos One, 2011
generated a variant of FGF19, FGF19-7, that has altered receptor specificity with a strong bias toward FGFR1c
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