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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fibroblast growth factor 18

FGF18, fibroblast growth factor 18
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Fibroblast Growth Factor 2, FGFR3, CAN, FGFR1, HAD
Papers on FGF18
Mechanisms of fibroblast growth factor signaling in the ovarian follicle.
Review
New
Price, Saint-Hyacinthe, Canada. In J Endocrinol, Feb 2016
Other FGFs have also been implicated in ovarian function, and this review summarizes the effects of members of two subfamilies on ovarian function; the FGF7 subfamily that also contains FGF10, and the FGF8 subfamily that also contains FGF18.
FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro.
New
Mailleux et al., Paris, France. In Am J Physiol Lung Cell Mol Physiol, Feb 2016
For instances, Fibroblast growth factor 9 (FGF9) and FGF18, involved in epithelial-mesenchymal interactions, are critical for lung development.
Osteoarthritis year in review 2015: clinical.
Review
New
Sharma, Chicago, United States. In Osteoarthritis Cartilage, Jan 2016
Symptom outcomes of pharmacologic treatments were reported for methotrexate, adalimumab, anti-nerve growth factor monoclonal antibodies, strontium ranelate, bisphosphonates, glucosamine, and chondroitin sulfate, and structural outcomes of pharmacologic treatments for strontium ranelate, recombinant human fibroblast growth factor 18, and glucosamine and chondroitin sulfate.
FGF signalling regulates bone growth through autophagy.
New
Impact
Settembre et al., Pozzuoli, Italy. In Nature, Jan 2016
Surprisingly, post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 and JNK-dependent activation of the autophagy initiation complex VPS34-beclin-1.
Perlecan domain I heparan sulfate ablation reduces progressive cartilage degradation, synovitis, and osteophyte size in post-traumatic osteoarthritis.
New
Melrose et al., Sydney, Australia. In Arthritis Rheumatol, Jan 2016
Changes in cartilage FGF2, FGF18, HSPG2, FGFreceptor(R)1 and FGFR3 were examined immunohistochemically.
Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection.
New
Jung et al., Seoul, South Korea. In Medicine (baltimore), Dec 2015
Loss of a locus containing FGF18 led to a worse, but gain of region including CDK10 and RAD18 led to better overall survival (OS) in all OSCC patients.
VEGF and Endothelium-Derived Retinoic Acid Regulate Lung Vascular and Alveolar Development.
New
Vu et al., Denver, United States. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
We determined that RA is produced by pulmonary endothelial cells and regulates pulmonary angiogenesis and elastin synthesis by induction of VEGF-A and FGF18, respectively.
Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array.
New
Birrer et al., Boston, United States. In Clin Cancer Res, Dec 2015
Two novel top biomarkers (FGF18 and GPR172A) were validated in serum samples from an independent patient cohort.
FGF18 as a potential biomarker in serous and mucinous ovarian tumors.
New
Sheasha et al., Alexandria, Egypt. In Tumour Biol, Nov 2015
UNASSIGNED: Fibroblast growth factor 18 (FGF18) has been suggested to play important roles in promoting progression of ovarian high-grade serous carcinoma.
Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice.
New
McCoy et al., Iowa City, United States. In Am J Physiol Lung Cell Mol Physiol, Oct 2015
FGF18 mRNA is more abundant in MF, whereas FGF10 mRNA predominated in LF, which also express FGFR1 IIIb, a receptor for FGF10.
Distal Transverse Arch to Left Carotid Artery Ratio Helps to Identify Infants With Aortic Arch Hypoplasia.
New
Alfieris et al., Rochester, United States. In Ann Thorac Surg, Sep 2015
Reverse transcription polymerase chain reaction confirmed that CoA with AAH was associated with an increased expression of genes involved in cardiac and vascular development and growth, including hepsin, fibroblast growth factor-18, and T-box 2. The clinical outcomes of 79 infants (AAH, 26; CoA, 53) demonstrated that 90.1% were free of hypertension at 13 years when managed with this surgical strategy.
Instability restricts signaling of multiple fibroblast growth factors.
New
Krejci et al., Brno, Czech Republic. In Cell Mol Life Sci, Jun 2015
We report that FGF1, FGF3, FGF4, FGF6, FGF8, FGF9, FGF10, FGF16, FGF17, FGF18, FGF20, and FGF22 exist as unstable proteins, which are rapidly degraded in cell cultivation media.
Physiological functions and underlying mechanisms of fibroblast growth factor (FGF) family members: recent findings and implications for their pharmacological application.
Review
Imamura, In Biol Pharm Bull, 2013
These include studies on the importance of βKlotho and glycosaminoglycans for the signaling of hormonal FGFs (FGF21 and FGF19); the physiological role of a paracrine FGF (FGF18) in hair cycle regulation; and the development of a stable, chimeric FGF protein composed of FGF1 and FGF2 domains suitable for radioprotection.
Fibroblast growth factor control of cartilage homeostasis.
Review
Im et al., Chicago, United States. In J Cell Biochem, 2013
Three members of the fibroblast growth factor (FGF) family, FGF-2, FGF-18, and FGF-8, have been implicated as contributing factors in cartilage homeostasis.
Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development.
GeneRIF
Bourbon et al., Créteil, France. In Physiol Genomics, 2011
These findings therefore argue for an involvement of FGF18 in the control of various developmental events during the alveolar stage.
Fgf-18 is required for osteogenesis but not angiogenesis during long bone repair.
GeneRIF
Quarto et al., Stanford, United States. In Tissue Eng Part A, 2011
Fgf-18 is an important mediator of bone regeneration, which is required during later stages of bone regeneration.
Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis.
GeneRIF
Grasl-Kraupp et al., Vienna, Austria. In Hepatology, 2011
FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis.
Autocrine fibroblast growth factor 18 mediates dexamethasone-induced osteogenic differentiation of murine mesenchymal stem cells.
GeneRIF
Marie et al., Paris, France. In J Cell Physiol, 2010
FGF18 is upregulated during osteoblast differentiation induced by dexamethasone in murine mesenchymal stem cells.
Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.
GeneRIF
Whitelock et al., Sydney, Australia. In Biochemistry, 2010
FGF2 and -18 bind to discrete structures on the heparan sulfate chains attached to chondrocyte-derived perlecan which modulate the growth factor activities
Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis.
Review
Im et al., Chicago, United States. In Gene, 2008
Two members of the fibroblast growth factor (FGF) family, basic FGF (bFGF) and FGF-18, have been implicated in the regulation of articular and intervertebral disc (IVD) cartilage homeostasis.
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