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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Fibroblast growth factor 12

FGF12, fibroblast growth factor homologous factor, FHF-1
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on FGF12
Identification of novel DNA methylation markers in colorectal cancer using MIRA-based microarrays.
Yang et al., Yinchuan, China. In Oncol Rep, 2012
PHOX2B, FGF12 and GAD2 genes are hypermethylated in colorectal neoplastic tissue
Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12.
Akashi et al., Chiba, Japan. In J Biol Chem, 2011
exogenous FGF12 can play a role in tissues by translocating into cells through the plasma membrane
Involvement of intracellular expression of FGF12 in radiation-induced apoptosis in mast cells.
Meineke et al., München, Germany. In J Radiat Res (tokyo), 2008
These findings suggest that FGF12 intracellularly suppresses radiation-induced apoptosis in mast cells independently of IB2.
Fibroblast growth factor homologous factor 1 (FHF1) is expressed in a subpopulation of calcitonin gene-related peptide-positive nociceptive neurons in the murine dorsal root ganglia.
Fichard-Carroll et al., Montpellier, France. In J Comp Neurol, 2008
results argue strongly against the possibility that FHF1 has a modulatory effect on the Na(v)1.9 sodium channel isoform in cRet+/IB4+ neurons, but FHF1 could play a role in a distinct subset of TrkA+/CGRP+ nociceptors.
Biophysical characterization of fibroblast growth factor homologous factor-1b (FHF-1b): sodium dodecyl sulfate promotes two state folding.
Jagannadham et al., Guwāhāti, India. In Protein Pept Lett, 2007
Data describe the biophysical characterization and folding of fibroblast growth factor homologous factor-1b (FHF-1b) in comparison with acidic fibroblast growth factor (FGF-1), and show that FHF-1 is significantly more stable than FGF-1.
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