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Fibroblast growth factor binding protein 1

FGF-BP, FGF-binding protein, HBp17, FGF-BP1, Fibroblast growth factor-binding protein
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: Fibroblast Growth Factor 2, CAN, ACID, 4E-BP1, KLF5
Papers on FGF-BP
Bacillus Calmette-Guerín vaccination: a novel therapeutic approach to preventing hyperoxic lung injury.
New
Ozkan et al., İzmir, Turkey. In J Matern Fetal Neonatal Med, Nov 2015
The expression of genes VEGF, FGF-BP1, IL-13, and NFκB1 (p50) in the lungs of the hyperoxia-exposed BCG-vaccinated group was significantly higher than that of the hyperoxia-exposed placebo group.
Eldecalcitol (ED-71), an analog of 1α,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.
Review
New
Okamoto et al., Hiroshima, Japan. In J Steroid Biochem Mol Biol, Nov 2015
UNASSIGNED: We have previously reported that 1,25(OH)2D3 inhibits NF-κB activity and thus inhibits growth of OSCC cells in serum-free culture and down-regulates HBp17/FGFBP-1 expression, which is important for cancer cell growth and angiogenesis.
Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth.
New
Yu et al., Taipei, Taiwan. In Mol Carcinog, Mar 2015
Microarray analysis demonstrated that oncogenic genes including fatty acid binding protein 4 (FABP4) and fibroblast growth factor binding protein 1 (HBP17), RGS4, tissue inhibitor of metalloproteinase 3 (TIMP3), WNT5b, URB, and collagen, type VIII, alpha 1 (COL8A1) responsible for proliferation, survival, inflammation, and carcinogenesis were significantly repressed by emodin.
1α,25(OH)₂D₃ inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1.
Okamoto et al., Hiroshima, Japan. In In Vitro Cell Dev Biol Anim, 2014
Heparin-binding protein 17/fibroblast growth factor binding protein-1 (HBp17/FGFBP-1, GenBank accession no.
Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma.
Wellstein et al., Washington, D.C., United States. In J Aids Clin Res, 2014
We carried out this study to determine whether an FGF-binding protein (FGFBP1 or BP1) that enhances the angiogenic activity of FGF-2 is expressed in AIDS-KS tumors, and to define whether BP1, FGF-2, and HIV-Tat protein-protein interactions could play a potential clinically role in the pathogenesis of AIDS-KS.
Fibroblast growth factor-2 expression in the preimplantation equine conceptus and endometrium of pregnant and cyclic mares.
Stout et al., Utrecht, Netherlands. In Theriogenology, 2013
This study investigated mRNA expression for FGF2, its receptors (FGFR1-4), the activating factor FGF binding protein (FGF-BP) in equine endometrium and trophectoderm during early pregnancy and the estrous cycle, and localized FGF2 protein in both endometrium and conceptus tissues.
1α,25OH2D3 down-regulates HBp17/FGFBP-1 expression via NF-κB pathway.
Review
Okamoto et al., Hiroshima, Japan. In J Steroid Biochem Mol Biol, 2013
The heparin binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1, GenBank accession no.
YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor.
Chen et al., Kunming, China. In Am J Pathol, 2012
Overexpression of the wild-type YAP but not the WW domain-mutated YAP up-regulated KLF5 protein levels and mRNA expression levels of KLF5 downstream target genes, including FGFBP1 (alias FGF-BP) and ITGB2.
TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis.
Chen et al., Kunming, China. In Carcinogenesis, 2012
Overexpression of TAZ upregulated the protein levels of KLF5 and FGF-BP, which is a well-established KLF5 target gene.
Impact of fibroblast growth factor-binding protein-1 expression on angiogenesis and wound healing.
Wellstein et al., Washington, D.C., United States. In Am J Pathol, 2011
FGFBP1 (alias BP1, FGF-BP1, or HBp17) expression is required for embryonic survival, can modulate FGF-dependent vascular permeability in embryos, and is an angiogenic switch in human cancers.
Fibroblast growth factor-binding protein facilitates the growth and migration of skin-derived precursors.
Liu et al., Guangzhou, China. In J Cutan Med Surg, 2011
FGF-binding protein (FGF-BP) plays a critical role in activating FGFs by releasing them from the extracellular matrix.
Pathway analysis shows association between FGFBP1 and hypertension.
GeneRIF
Samani et al., Leicester, United Kingdom. In J Am Soc Nephrol, 2011
FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations.
Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma.
Aigner et al., Marburg an der Lahn, Germany. In Mol Cancer, 2010
One mechanism of their bioactivation relies on the FGF-binding protein (FGF-BP) which, upon reversible binding to FGF-1 or -2, leads to their release from the ECM.
A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro.
GeneRIF
Mitchell et al., Baltimore, United States. In Bone, 2010
Sequence variation in FGFBP1 may contribute to variation in bone mineral density, possibly influencing osteoporosis risk.
Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.
GeneRIF
Chen et al., Albany, United States. In Oncogene, 2009
KLF5 may promote breast cancer cell proliferation at least partially through directly activating the FGF-BP mRNA transcription.
KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.
GeneRIF
Chen et al., Albany, United States. In J Biol Chem, 2009
KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.
Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury.
GeneRIF
Wellstein et al., Washington, D.C., United States. In Am J Physiol Regul Integr Comp Physiol, 2007
FGF-BP is an early response gene after spinal cord injury and that its upregulation in regenerating spinal cord tissue may provide a molecular mechanism for enhancing the initial FGF2-mediated neurotrophic effects occurring after such tissue damage
The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma.
Review
Wellstein et al., Washington, D.C., United States. In Semin Oncol, 2006
A secreted fibroblast growth factor (FGF) binding protein (FGF-BP), which is an extracellular chaperone molecule for FGFs, has been shown to enhance FGF-mediated biochemical and biologic events and to be a crucial rate-limiting factor for tumor-dependent angiogenesis.
The fibroblast growth factor-binding protein FGF-BP.
Review
GeneRIF
Aigner et al., Marburg an der Lahn, Germany. In Int J Biochem Cell Biol, 2005
FGF-BP can be rate-limiting for tumor growth and serves as an angiogenic switch molecule, and that it represents an increasingly promising target molecule in anti-tumor therapy[review]
A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.
Impact
Wellstein et al., Washington, D.C., United States. In Nat Med, 1997
Here we investigated whether the expression in tumors of a secreted fibroblast growth factor (FGF)-binding protein (FGF-BP) that mobilizes and activates locally stored FGFs (ref.
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