Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth.
Taipei, Taiwan. In Mol Carcinog, Mar 2015
Microarray analysis demonstrated that oncogenic genes including fatty acid binding protein 4 (FABP4) and fibroblast growth factor binding protein 1 (HBP17), RGS4, tissue inhibitor of metalloproteinase 3 (TIMP3), WNT5b, URB, and collagen, type VIII, alpha 1 (COL8A1) responsible for proliferation, survival, inflammation, and carcinogenesis were significantly repressed by emodin.
The fibroblast growth factor-binding protein FGF-BP.
Marburg an der Lahn, Germany. In Int J Biochem Cell Biol, 2005
FGF-BP can be rate-limiting for tumor growth and serves as an angiogenic switch molecule, and that it represents an increasingly promising target molecule in anti-tumor therapy[review]