[Ewing/PNET sarcoma family of tumors: towards a new paradigm?].
Lyon, France. In Ann Pathol, 2015
Besides the rearrangements between the FET family of genes (EWS or FUS) and the wide ETS family of genes (FLI1, ERG, FEV, ETV…), new partner genes are gradually identified: cases with EWS-non ETS partners are extremely rare, but there are more important groups which are CIC-DUX4 and BCOR-CCNB3 translocation-positive sarcomas.
Probing the diversity of serotonin neurons.
Paris, France. In Philos Trans R Soc Lond B Biol Sci, 2012
In both species, PET1 plays a major role in the acquisition and maintenance of 5-HT identity in the hindbrain, although some 5-HT neurons do not require PET1 for their differentiation, indicating the existence of several transcriptional routes to become serotoninergic.
Roflumilast--a phosphodiesterase-4 inhibitor licensed for add-on therapy in severe COPD.
Zürich, Switzerland. In Swiss Med Wkly, 2011
Roflumilast is a selective phosphodiesterase 4 inhibitor which has been licensed in the European Union since 2010 and in Switzerland since November 2011 as an add-on treatment for patients with chronic obstructive pulmonary disease (COPD) in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages 3 and 4 (FEV(1) <50% predicted after bronchodilatation) and frequent exacerbations despite correctly-dosed therapy with a long-acting bronchodilator.
Lebrikizumab treatment in adults with asthma.
Los Angeles, United States. In N Engl J Med, 2011
The primary efficacy outcome was the relative change in prebronchodilator forced expiratory volume in 1 second (FEV(1)) from baseline to week 12.