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Protein phosphatase, Mg2+/Mn2+ dependent, 1F

fem-2, Ca(2+)/calmodulin-dependent protein phosphatase, PP2C phosphatase, Ca(2+)/calmodulin-dependent protein kinase phosphatase, POPX2
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, HAD, CaM
Papers on fem-2
Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) by protocadherin-γC5 (Pcdh-γC5).
New
Sueyoshi et al., Japan. In Arch Biochem Biophys, Dec 2015
Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) is a Ser/Thr protein phosphatase that belongs to the PPM family.
The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans.
New
Mains et al., Calgary, Canada. In Dev Biol, Oct 2015
This process is controlled by two redundant pathways, one involving the small GTPase RHO-1 and its downstream effectors LET-502/Rho-binding kinase and MEL-11/myosin phosphatase, and another involving PAK-1/p21 activated kinase and FEM-2/PP2c phosphatase.
Temporal and spatial temperature distributions on glabrous skin irradiated by a 1940 nm continuous-wave laser stimulator.
New
Li et al., Tianjin, China. In Biomed Opt Express, May 2015
For predicting pain stimulation effects and avoiding damage in 1940nm laser evoked potentials (LEPs) experiments, a 2-layer finite element model (FEM-2) was constructed.
Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin.
Hirata et al., Hiroshima, Japan. In Biosci Biotechnol Biochem, 2014
Calcineurin, which is a Ca(2+)/calmodulin-dependent protein phosphatase, is a key mediator in calcium signaling in diverse biological processes and of clinical importance as the target of the immunosuppressant FK506.
The HAB1 PP2C is inhibited by ABA-dependent PYL10 interaction.
Tian et al., Hefei, China. In Sci Rep, 2014
Previous studies reported that the PP2C phosphatase inhibition by PYL10 was ABA-independent.
A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.
Venkatachalam et al., Houston, United States. In Neuron, 2014
We find that Iav activates the Ca(2+)/calmodulin-dependent protein phosphatase calcineurin, which is essential for presynaptic microtubule stabilization at the neuromuscular junction.
Reduced Dormancy5 encodes a protein phosphatase 2C that is required for seed dormancy in Arabidopsis.
Soppe et al., Köln, Germany. In Plant Cell, 2014
Cloning of RDO5 showed that it encodes a PP2C phosphatase.
Calcineurin-Crz1 signaling in lower eukaryotes.
Review
Thewes, Berlin, Germany. In Eukaryot Cell, 2014
An increase in the cytosolic Ca(2+) concentration activates many proteins, including calmodulin and the Ca(2+)/calmodulin-dependent protein phosphatase calcineurin.
RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.
Grill et al., Minneapolis, United States. In Plos Genet, 2014
Our results also highlight an important and expanding role for the PP2C phosphatase family in neuronal development.
POPX2 phosphatase regulates cell polarity and centrosome placement.
Koh et al., Singapore, Singapore. In Cell Cycle, 2013
In this study, we investigated the regulation of centrosome polarization and have identified the phosphatase POPX2 as an important regulator of centrosome orientation.
Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP) by oxidation/reduction at Cys-359.
GeneRIF
Kameshita et al., Japan. In Arch Biochem Biophys, 2012
hCaMKP activity is reversibly regulated by oxidation/reduction at Cys-359
MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.
GeneRIF
Sahin et al., Heidelberg, Germany. In Mol Cell Biol, 2012
FHOD1 and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR-200c. Expression levels of FHOD1 and PPM1F were inversely correlated with miR-200c level in breast cancer cell lines and breast cancer patient samples.
Regulation of the Wip1 phosphatase and its effects on the stress response.
Review
Fornace et al., United States. In Front Biosci, 2011
Wip1 (PPM1D) is a stress responsive PP2C phosphatase that plays a key role in stress signaling.
Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis.
GeneRIF
Koh et al., Singapore, Singapore. In Proteomics, 2011
Data identify a biochemical pathway through which POPX2 exerts its apparent cellular function: the regulation of activity of glycogen synthase kinase-3, which in turn modulates extracellular signal-regulated kinase and cell motility.
Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling.
Review
Xu et al., Grand Rapids, United States. In Curr Opin Struct Biol, 2010
Together, these structures provide a detailed gate-latch-lock mechanism of ABA recognition, receptor-PP2C interaction, and inhibition of the PP2C phosphatase activity and provide a basis for the design of synthetic ABA agonists for stress protection of crop plants.
Calcineurin and electrical remodeling in pathologic cardiac hypertrophy.
Review
Dong et al., Harbin, China. In Trends Cardiovasc Med, 2010
Calcineurin is a cytoplasmic Ca(2+)/calmodulin-dependent protein phosphatase that contributes to cardiac hypertrophy.
The POPX2 phosphatase regulates cancer cell motility and invasiveness.
GeneRIF
Koh et al., Singapore, Singapore. In Cell Cycle, 2010
The POPX2 phosphatase regulates cancer cell motility and invasiveness.
Regulators of PP2C phosphatase activity function as abscisic acid sensors.
Impact
Grill et al., Freising, Germany. In Science, 2009
The plant hormone abscisic acid (ABA) acts as a developmental signal and as an integrator of environmental cues such as drought and cold.
Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts.
GeneRIF
Ozer et al., Newark, United States. In J Biol Chem, 2004
PPM1F plays a key role in the regulation of CaMKII intracellularly
Regulation of voltage-dependent sodium channel expression in adrenal chromaffin cells: involvement of multiple calcium signaling pathways.
Review
Wada et al., Miyazaki, Japan. In Ann N Y Acad Sci, 2002
The inhibition of calcineurin, a Ca(2+)/calmodulin-dependent protein phosphatase 2B, by immunosuppressants upregulated cell surface Na(+) channels by both stimulating externalization and inhibiting internalization of the channels without changing Na(+) channel alpha- and beta(1)-subunit mRNA levels.
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