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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

AF4/FMR2 family, member 1

Fel, AF4, MLL/AF4
Papers on Fel
The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription.
Moffat et al., Toronto, Canada. In Cancer Res, 2012
our findings show AF4-dependent regulation of CD133 expression, which is required for the growth of acute lymphoblastic leukemia cells
Methylation-mediated repression of microRNA-143 enhances MLL-AF4 oncogene expression.
Yu et al., Beijing, China. In Oncogene, 2012
miR-143 functions as a tumor suppressor in MLL-AF4 B-cell acute lymphoblastic leukemia.
A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.
Yamamoto et al., Yokohama, Japan. In Plos Genet, 2012
we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with Systemic lupus erythematosus susceptibility (rs340630; P = 8.3x10(-9), odds ratio = 1.21
Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement.
Menendez et al., Granada, Spain. In Leukemia, 2011
MLL-AF4 leukemogenesis has been particularly difficult to model and bona fide MLL-AF4 disease models do not exist so far.[review]
The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.
Marschalek et al., Frankfurt am Main, Germany. In Leukemia, 2011
findings suggest that the AF4-MLL protein disturbs the fine-tuned activation cycle of promoter-arrested RNA Pol II and causes altered histone methylation signatures
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