The multiple facets of FcRn in immunity.
Amsterdam, Netherlands. In Immunol Rev, Nov 2015
The neonatal Fc receptor, FcRn, is best known for its role in transporting IgG in various tissues, providing newborns with humoral immunity, and for prolonging the half-life of IgG.
Pharmacokinetic characteristics of therapeutic antibodies.
Halle, Germany. In J Dtsch Dermatol Ges, Jun 2015
Also relevant is the elimination through target antigens (especially in the case of cell-bound target antigens) as well as a recycling process through binding to the neonatal Fc receptor that provides protection from lysosomal degradation.