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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fc receptor-like A

FCRL, FCRL1, FREB, FcRH1, FcRX, FCRLA
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CAN, IRTA2, HAD, IRTA1, BCR
Papers on FCRL
MRI phenotypes with high neurodegeneration are associated with peripheral blood B-cell changes.
New
Montalban et al., Madrid, Spain. In Hum Mol Genet, Feb 2016
Microarray analysis revealed the B-cell specific genes FCRL1, FCRL2, FCRL5 (Fc receptor-like 1, 2 and 5 respectively), and CD22 as the top differentially expressed genes between patients with high and low neurodegeneration.
FCRL regulation in innate-like B cells.
Review
New
Davis, Birmingham, United States. In Ann N Y Acad Sci, Dec 2015
Members of the Fc receptor-like (FCRL) family are preferentially expressed by B cells and possess tyrosine-based immunoregulatory function.
Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease.
New
Amirghofran et al., Shīrāz, Iran. In Horm Metab Res, Aug 2015
Recently identified Fc receptor-like (FCRL) molecules are new members of the immunoglobulin superfamily dominantly expressed by B cells.
Correlation between single nucleotide polymorphism of FCRL-3 gene and Graves' disease in Han population of northern Anhui province, China.
Bi et al., Bengbu, China. In Int J Clin Exp Med, 2014
OBJECTIVE: The frequency distribution of A/G genotype at position-169 in promoter of FCRL3 gene (Fc receptor-like 3) was identified in Han population of northern Anhui Province.
Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling.
Shokri et al., Tehrān, Iran. In Immunology, 2014
None of the mAbs displayed any cross-reactivity with the other members of the FCRL family including recombinant FCRL1, -3, -4 and -5, as tested by FACS and ELISA techniques.
Interindividual variation in human T regulatory cells.
Benoist et al., Boston, United States. In Proc Natl Acad Sci U S A, 2014
There was a range of variability in Treg signature transcripts, some almost invariant, others more variable, with more extensive variability for genes that control effector function (ENTPD1, FCRL1) than for lineage-specification factors like FOXP3 or IKZF2.
CD21(-/low) marginal zone B cells highly express Fc receptor-like 5 protein and are killed by anti-Fc receptor-like 5 immunotoxins in hepatitis C virus-associated mixed cryoglobulinemia vasculitis.
Cacoub et al., Paris, France. In Arthritis Rheumatol, 2014
Fc receptor-like (FCRL) proteins comprise a family of immunoregulatory proteins preferentially expressed on B lineage cells.
Emerging roles for the FCRL family members in lymphocyte biology and disease.
Review
Davis et al., Birmingham, United States. In Curr Top Microbiol Immunol, 2013
Members of the extended Fc receptor-like (FCRL) family in humans and mice are preferentially expressed by B cells and possess tyrosine-based immunoregulatory function.
FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation.
Davis et al., Birmingham, United States. In Eur J Immunol, 2013
Fc receptor-like (FCRL) molecules are preferentially expressed by B lymphocytes and possess tyrosine-based immunoregulatory function.
Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors.
Tolnay et al., Silver Spring, United States. In J Immunol, 2013
Fc receptor-like (FCRL) 5 regulates B cell Ag receptor signaling and has been reported to bind aggregated IgG.
Characterization of human FCRLA isoforms.
Mechetina et al., Novosibirsk, Russia. In Immunol Lett, 2013
FCRLA is an ER-resident B-cell specific protein.
Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes.
Szyf et al., Montréal, Canada. In Plos One, 2012
Differences in HRM in the immunoglobulin superfamily Fc receptor (FCRL1) separated invasive tumors from less invasive HCC.
[Expression of human B-cell specific receptor FCRL1 in normal individuals and in patients with autoimmune diseases].
GeneRIF
Naiakshin et al., In Mol Biol (mosk), 2012
Expression level of FCRL1 gene in peripheral blood B-lymphocytes is significantly higher in patients with autoimmune diseases.
FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA.
GeneRIF
Burrows et al., Birmingham, United States. In Int Immunol, 2011
The studies reported here demonstrate that FCRLA is more broadly expressed among human B lineage cells than originally reported; it is found at significant levels in resting blood B cells and at varying levels in all B-cell subsets in tonsil.
Immunoregulatory roles for fc receptor-like molecules.
Review
Cooper et al., Atlanta, United States. In Curr Top Microbiol Immunol, 2010
Fc receptor-like (FCRL) molecules comprise a family of imunoregulatory transmembrane proteins that are preferentially, but not exclusively expressed on B lineage cells.
Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses.
GeneRIF
Colonna et al., Saint Louis, United States. In J Immunol, 2010
Analysis of human cell lines has confirmed that FcRLA is not secreted but is maintained as an intracellular protein in B cells where it interacts with immunoglobulins.
Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia.
GeneRIF
Shokri et al., Tehrān, Iran. In Cancer Immunol Immunother, 2009
Down-regulation of FCRL1 is associated with acute lymphoblastic leukemia.
Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
GeneRIF
Shokri et al., Tehrān, Iran. In Int J Cancer, 2008
Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
Fc receptor-like molecules.
Review
Impact
Davis, Birmingham, United States. In Annu Rev Immunol, 2006
Discovery of a large family of Fc receptor-like (FCRL) molecules, homologous to the well-known receptors for the Fc portion of immunoglobulin (FCR), has uncovered an impressive abundance of immunoglobulin superfamily (IgSF) genes in the human 1q21-23 chromosomal region and revealed significant diversity for these genes between humans and mice.
An extended family of Fc receptor relatives.
Review
Cooper et al., Birmingham, United States. In Eur J Immunol, 2005
The six human FcR homologs (FcRH1-6), which belong to a phylogenetically conserved gene family, have variable numbers of extracellular immunoglobulin domains of five different subtypes.
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