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Membrane-spanning 4-domains, subfamily A, member 2

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: IgE, MAST, HAD, CD20, CAN
Papers on FCER1B
Association of the MS4A2 gene promoter C-109T or the 7th exon E237G polymorphisms with asthma risk: a meta-analysis.
Huang et al., Wuhan, China. In Clin Biochem, May 2014
BACKGROUND AND OBJECTIVE: A large number of studies have examined the association between the Membrane-spanning 4 domains, superfamily A, number 2 (MS4A2) gene C-109T (rs1441586) or E237G (rs569108) variants and asthma risk.
Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2.
Nishiyama et al., Tokyo, Japan. In J Immunol, May 2014
Chromatin immunoprecipitation assay showed that significant amounts of PU.1, GATA1, and GATA2 bind to the promoter region of FCER1A (encoding FcεRIα) and that GATA2 binds to the promoter of MS4A2 (encoding FcεRIβ).
De novo diffuse large B-cell lymphoma with a CD20 immunohistochemistry-positive and flow cytometry-negative phenotype: molecular mechanisms and correlation with rituximab sensitivity.
Naoe et al., Nagoya, Japan. In Cancer Sci, Jan 2014
CD20 (MS4A1) mRNA expression was significantly lower in IHC(+)/FCM(-) cells than in IHC(+)/FCM(+) cells (P = 0.0005).
Impact of capsaicin on mast cell inflammation.
Pandolfi et al., Thessaloníki, Greece. In Int J Immunopathol Pharmacol, Jul 2013
Mast cells possess high-affinity receptors for IgE (FcERI) and the cross-linking of these receptors is essential to trigger the secretion of granules containing arachidonic acid metabolism (such as prostaglandin (PG) D2, leukotriene (LT) B4, and LTC4), histamine, cytokines, chemokines, and proteases, including mast cell-specific chymases and tryptases.
Epigenetic regulation of CD34 and HIF1A expression during the differentiation of human mast cells.
Dastych et al., Łódź, Poland. In Immunogenetics, Jun 2013
While the expression of CD34 dramatically decreased, the expression of mast cell-specific genes, including FCER1A, MS4A2, TPSB2, and CMA1, steadily increased.
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.
Metcalfe et al., Bethesda, United States. In Immunity, Jun 2013
Human linkage analyses have implicated the MS4A2-containing gene locus (encoding FcεRIβ) as a candidate for allergy susceptibility.
B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients.
Reinke et al., Praha, Czech Republic. In Transplantation, Feb 2013
METHODS: In this prospective study, the gene expression profiles of eight selected tolerance-associated genes (MS4A1, CD79B, TCL1A, TMEM176B, FOXP3, TOAG-1, MAN1A1, and TLR5) in the peripheral blood of 67 kidney transplant recipients at days 0, 7, 14, 21, 28, 60, 90, and at 6 and 12 months, and in graft biopsies were measured.
Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects.
Flores et al., Madrid, Spain. In Plos One, 2012
BACKGROUND: Before the advent of genome-wide association studies (GWAS), ADAM33, ADRB2, CD14, MS4A2 (alias FCER1B), IL13, IL4, IL4R, and TNF constituted the most replicated non-HLA candidate genes with asthma and related traits.
[Study of genetic susceptibility in 198 children with asthma].
Li et al., Shiqi, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2012
OBJECTIVE: To analyze the frequency distribution of single nucleotide polymorphisms (SNPs) of four asthma-related gene loci (ACE I/D; ADRB2 Arg16Gly; TNF-α G-308A; MS4A2 Glu237Gly) in 198 asthmatic children, and to investigate its association with genetic susceptibility to childhood asthma and some clinical phenotypes of asthma.
(99m)Tc-Labeled rituximab, a chimeric murine/human anti-CD20 monoclonal antibody
Chopra, Bethesda, United States. In Unknown Journal, 2012
Rituximab is a chimeric murine/human monoclonal antibody (mAb) that targets the CD20 antigen (also known as membrane-spanning 4-domains, subfamily A, member 1; or MS4A1), which is expressed on 95% of the transformed B-cells that participate in the pathogenesis of non-Hodgkin lymphomas (NHL; diffused large-B cell, low-grade, or the follicular types), a hematological malignancy, and autoimmune diseases such as rheumatoid arthritis (RA), granulomatosis with polyangiitis (Wegener's granulomatosis), and microscopic polyangiitis.
(64)Cu-Labeled DOTA-conjugated rituximab, a chimeric murine/human anti-CD20 monoclonal antibody
Chopra, Bethesda, United States. In Unknown Journal, 2012
Rituximab is a chimeric murine/human monoclonal antibody (mAb) that targets the CD20 antigen (also known as membrane-spanning 4-domains, subfamily A, member 1, or MS4A1) and has been approved by the United States Food and Drug Administration for the treatment of non-Hodgkins lymphomas (NHL; diffused large-B cell, low-grade, or follicular types), rheumatoid arthritis, granulomatosis with polyangiitis (Wegener's granulomatosis) and microscopic polyangiitis.
Demethylation of the FCER1G promoter leads to FcεRI overexpression on monocytes of patients with atopic dermatitis.
Lu et al., Changsha, China. In Allergy, 2012
Demethylation of specific regulatory elements within the FCER1G locus contributes to FcepsilonRI overexpression on monocytes from patients with atopic dermatitis.
Mucosal immunity and sublingual immunotherapy in respiratory disorders.
La Rosa et al., Catania, Italy. In J Biol Regul Homeost Agents, 2012
Recent literature data stated the presence in oral mucosa of dendritic cells (DCs) which express the high-affinity receptor for immunoglobulin (Ig)E (FcERI).
Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk.
Weidinger et al., Liège, Belgium. In Allergy, 2010
No associations with total and specific IgE levels as well as allergic sensitization were seen for FCER1B and FCER1G
Characterization of the methylation patterns of MS4A2 in atopic cases and controls.
Duffy et al., Brisbane, Australia. In Allergy, 2010
Methylation levels at the AluSp repeat analysed in MS4A2 were inconsistent with classical imprinting mechanisms and did not associate with atopy status
Update on recent advances in the management of aspirin exacerbated respiratory disease.
Park et al., Suwŏn, South Korea. In Yonsei Med J, 2010
Potential genetic biomarkers contributing to the AERD phenotype include HLA-DPB1*301, LTC4S, ALOX5, CYSLT, PGE2, TBXA2R, TBX21, MS4A2, IL10 -1082A > G, ACE -262A > T, and CRTH2 -466T > C; the four-locus SNP set was composed of B2ADR 46A > G, CCR3 -520T > G, CysLTR1 -634C > T, and FCER1B -109T > C. Management of AERD is an important issue.
Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma.
Kim et al., Seoul, South Korea. In Eur J Pediatr, 2009
Polymorphisms in the Fc epsilon R1beta gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways in asthmatic patients.
A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.
ISAAC Phase 2 Study Group et al., Ulm, Germany. In Clin Exp Allergy, 2009
Significant associations of single nucleotide polymorphisms with wheeze in the past year were detected in only four genes (IL4R, TLR4, MS4A2, TLR9). Variants in IL4R and TLR4 were also related to allergen-specific IgE, but not for MS4A2 and TLR9.
Infections and mast cells.
Shaik et al., In J Biol Regul Homeost Agents, 2009
Mast cells are activated by cross-linking of FcERI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators.
What do we know about the genetics of aspirin intolerance?
Park et al., Suwŏn, South Korea. In J Clin Pharm Ther, 2008
An additional low-risk genetic marker for AIA is MS4A2, which encodes the beta-chain of FCER1.
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