The MS4A family: counting past 1, 2 and 3.
Melbourne, Australia. In Immunol Cell Biol, Jan 2016
The MS4A (membrane-spanning 4-domain family, subfamily A) family of proteins contains some well-known members including MS4A1 (CD20), MS4A2 (FcɛRIβ) and MS4A3 (HTm4).
Interferon at the crossroads of allergy and viral infections.
Dallas, United States. In J Leukoc Biol, Aug 2015
These findings support a model, whereby allergic and antiviral responses are able to cross-regulate each other, as IgER cross-linking of pDCs prevents IFN-α/β production in response to viral infection.
Identification of IL13 C1923T as a Single Nucleotide Polymorphism for Asthma in Children from Mauritius.
Shanghai, China. In Pediatr Allergy Immunol Pulmonol, Jul 2015
Results: No statistically significant differences (p>0.05) were found between the experimental and control group in genotype distribution among nine of the loci (MS4A2 E237G, MS4A2 C-109T, ADRB2 R16G, IL4RA Q551R, IL4RA I75V, IL4 C-590T, IL13 A2044G, IL13 C-1112T, and CHI3L1 C-131G).
MS4A Cluster in Alzheimer's Disease.
Qingdao, China. In Mol Neurobiol, Jun 2015
Besides, although the MS4A family members are poorly characterized, an important role in immunity has already been identified for several members of this cluster (such as MS4A1, MS4A2, and MS4A4B), indicating the possible involvement of MS4A gene cluster in AD pathogenesis.
The expression of B & T cell activation markers in children's tonsils following live attenuated influenza vaccine.
Bergen, Norway. In Hum Vaccin Immunother, 2014
Meanwhile at 6-7 days post vaccination, 9 genes were significantly up-regulated, including RIPK2, TGFB1, MICB, SOCS1, IL2RA, MS4A1, PTPRC, IL2 and IL8.
Impact of capsaicin on mast cell inflammation.
Thessaloníki, Greece. In Int J Immunopathol Pharmacol, 2013
Mast cells possess high-affinity receptors for IgE (FcERI) and the cross-linking of these receptors is essential to trigger the secretion of granules containing arachidonic acid metabolism (such as prostaglandin (PG) D2, leukotriene (LT) B4, and LTC4), histamine, cytokines, chemokines, and proteases, including mast cell-specific chymases and tryptases.
(99m)Tc-Labeled rituximab, a chimeric murine/human anti-CD20 monoclonal antibody
Bethesda, United States. In Unknown Journal, 2012
Rituximab is a chimeric murine/human monoclonal antibody (mAb) that targets the CD20 antigen (also known as membrane-spanning 4-domains, subfamily A, member 1; or MS4A1), which is expressed on 95% of the transformed B-cells that participate in the pathogenesis of non-Hodgkin lymphomas (NHL; diffused large-B cell, low-grade, or the follicular types), a hematological malignancy, and autoimmune diseases such as rheumatoid arthritis (RA), granulomatosis with polyangiitis (Wegener's granulomatosis), and microscopic polyangiitis.