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F-box and WD repeat domain containing 8

FBXW8, Fbx29, Fbw8, Fbw6
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, p185, Cullin, Skp1, Rbx1
Papers using FBXW8 antibodies
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
Supplier
Kyprianou Natasha, In PLoS ONE, 2008
... Fbw7, Invitrogen (Carlsbad, CA); Myc, Cell Signaling Technology (Beverly, MA); Cdh1, Millipore (Billerica, MA); Fbx2, Fbxw8, Novus Biologicals (Littleton, CO); β-actin, MP ...
Papers on FBXW8
An improved model of predicting hepatocarcinogenic potential in rats by using gene expression data.
New
Saito et al., Ōsaka, Japan. In J Appl Toxicol, Feb 2016
The assigned 42 probe sets have included the cancer- or c-Myc-related genes such as Hsp90, Pink1, Hspc111, Fbx29, Hepsin, Syndecan2 and Synbindin.
The emerging roles of F-box proteins in pancreatic tumorigenesis.
Review
New
Wang et al., Houston, United States. In Semin Cancer Biol, Oct 2015
In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression.
Genomic structural variants are linked with intellectual disability.
New
Thompson et al., Moscow, Russia. In J Neural Transm, Sep 2015
19 out of 21 ID cases carried segmental CNV and 20 of 21 them displayed ROH segments with mean size lengths for ID cases 2512 kb (500-6,472 kb) and for healthy control 682 kb (531-986 kb), including the genes MED13L, HRK, FBXW8, TESC, CDK2AP1 and SBNO1.
Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
Auburger et al., Frankfurt am Main, Germany. In Plos One, 2014
We previously reported evidence for a transcriptional induction of the multi-subunit RING finger Skp1/Cul/F-box (SCF) type E3 ubiquitin-protein ligase complex component FBXW8 in global microarray profiling of ATXN2-expansion mouse cerebellum and demonstrated its role for ATXN2 degradation in vitro.
MicroRNA-218 inhibits the proliferation of human choriocarcinoma JEG-3 cell line by targeting Fbxw8.
Zhang et al., Changsha, China. In Biochem Biophys Res Commun, 2014
In this study, we showed that miR-218 expression levels were decreased while Fbxw8 expression levels were increased in human choriocarcinoma cell lines, and identified Fbxw8 as a novel direct target of miR-218.
ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal.
Dong et al., Austin, United States. In Stem Cell Res, 2014
Further, we found that this phosphorylation induces binding of FBXW8 with Nanog to reduce Nanog protein stability.
The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
Wang et al., In J Biol Chem, 2014
We found that the CUL7/Fbxw8 ubiquitin ligase targeted HPK1 for degradation via the 26 S proteasome.
Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.
Sarikas et al., München, Germany. In Cell Signal, 2014
In vivo, heterozygosity of either Cul7 or Fbxw8, both key components of CRL7, resulted in elevated PI3 kinase/AKT activation in skeletal muscle tissue upon insulin stimulation when compared to wild-type controls.
Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2).
Review
Jacinto et al., United States. In Biochem Soc Trans, 2013
Defective IRS-1 degradation was due to attenuated expression of the CUL7 (Cullin 7) ubiquitin ligase substrate-targeting sub-unit Fbw8.
Liver kinase b1 is required for white adipose tissue growth and differentiation.
Zou et al., Oklahoma City, United States. In Diabetes, 2013
Silencing of Fbw8 increased IRS1 levels.
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
Jacinto et al., United States. In Mol Cell, 2013
Defective IRS-1 degradation was due to attenuated expression and phosphorylation of the ubiquitin ligase substrate-targeting subunit, Fbw8.
Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines.
Udagawa et al., Japan. In Nutr Cancer, 2012
We sought to determine whether the important MAPK signaling pathway, in the cyclin D1 cascade, including FBXW8, Cullin1, and the ubiquitination pathway mediated these effects.
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Impact
Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium et al., Seattle, United States. In Nat Genet, 2012
In two additional samples (n = 2,318), associations were replicated at 12q14 within MSRB3-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10(-11)) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 × 10(-11)).
Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells.
GeneRIF
Yu et al., Harbin, China. In Mol Biol Rep, 2011
Fbxw8 plays an essential role in the proliferation of human trophoblast cells, especially JEG-3 cells.
The cullin7 E3 ubiquitin ligase: a novel player in growth control.
Review
Pan et al., New York City, United States. In Cell Cycle, 2008
Cullin7 (CUL7) is a molecular scaffold that organizes an E3 ubiquitin ligase containing the F-box protein Fbw8, Skp1 and the ROC1 RING finger protein.
Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.
GeneRIF
Decaprio et al., Boston, United States. In Mol Cell Biol, 2008
FBXW8-CUL7 complex plays a significant role in growth control
Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.
GeneRIF
Nakayama et al., Fukuoka, Japan. In Mol Cell Biol, 2006
Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8.
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.
GeneRIF
Tetsu et al., San Francisco, United States. In Plos One, 2005
Depletion of FBXW8 caused a significant accumulation of cyclin D1, as well as sequestration of CDK1 in the cytoplasm. This resulted in a severe reduction of cell proliferation.
Identification of mutations in CUL7 in 3-M syndrome.
Impact
Cormier-Daire et al., Paris, France. In Nat Genet, 2005
CUL7 assembles an E3 ubiquitin ligase complex containing Skp1, Fbx29 (also called Fbw8) and ROC1 and promotes ubiquitination.
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