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F-box protein 9

FBXO9, F-box protein 9
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, AML1, IL-1beta, TLR2, IgE
Papers on FBXO9
F-box only protein 9 is required for adipocyte differentiation.
Park et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2013
The objective of this study is to investigate whether F-box only protein 9 (FBXO9), an ubiquitination E3 ligase, has a functional role in adipocyte differentiation.
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Impact
Bassermann et al., München, Germany. In Nat Cell Biol, 2013
Significantly, primary human multiple myelomas exhibit high levels of Fbxo9.
Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3.
Jackman et al., Boston, United States. In Plos One, 2010
Fbxo9, Psma6, Psmc4, Psmg4, Foxo3, Ankrd1 (CARP), and Eif4ebp1 did not show changes in p65, p50, or Bcl-3 binding to κB sites, and so were considered indirect targets of p50 and Bcl-3.
The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors.
GeneRIF
Mayo et al., Charlottesville, United States. In Mol Cancer, 2009
ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island.
Identification of novel genes that mediate innate immunity using inbred mice.
Schwartz et al., Denver, United States. In Genetics, 2009
In summary, our analysis identified 4 genes that have not previously been implicated in innate immunity, namely, 1110058L19Rik, 4933415F23Rik, Fbxo9, and Ipo7.
A multi-gene approach to differentiate papillary thyroid carcinoma from benign lesions: gene selection using support vector machines with bootstrapping.
Swierniak et al., Gliwice, Poland. In Endocr Relat Cancer, 2007
We specified 43 genes which are most suitable as molecular markers of PTC, among them some well-known PTC markers (MET, fibronectin 1, dipeptidylpeptidase 4, or adenosine A1 receptor) and potential new ones (UDP-galactose-4-epimerase, cadherin 16, gap junction protein 3, sushi, nidogen, and EGF-like domains 1, inhibitor of DNA binding 3, RUNX1, leiomodin 1, F-box protein 9, and tripartite motif-containing 58).
Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy.
Yamakawa et al., Wako, Japan. In Neurosci Lett, 2006
Here, we describe detailed physical and transcriptome maps of the 3.5cM EJM1 region, and detailed results of mutation analyses for the remained 14 genes (HELO1, GCMA, KIAA0936, FBXO9, GSTA3, GSTA4, PTD011, KIAA0576, LMPB1, IL17F, MCM3, PKHD1, KIAA0105, TFAP2B) in patients with JME.
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