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F-box protein 2

Fbs1, NFB42, Fbx2, FBG2, Fbs2
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, SCF, Skp1, CD45, Cullin
Papers using Fbs1 antibodies
APC/CandSCF:controlling each other and the cell cycle
Li Nan et al., In Journal of Experimental & Clinical Cancer Research : CR, 2003
... FBG2 monoclonal antibody was purchased from Abcam company (USA), PCDNA3.1 vector ...
Papers on Fbs1
The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.
Mizushima et al., Nagoya, Japan. In Plos One, 2014
Among these, Fbs1/FBG1/FBXO2, Fbs2/FBG2/FBXO6, and Fbs3/FBG5/FBXO27 recognize the N-glycans of glycoproteins, whereas FBG3/FBXO44 has no sugar-binding activity, despite the high sequence homology and conservation of the residues necessary for oligosaccharide binding between Fbs1-3 and FBG3.
Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein.
West et al., Oklahoma City, United States. In Biochemistry, 2014
Interaction studies with the soluble mammalian F-box protein Fbs1/Fbg1/OCP1 revealed preferential binding to the glycosylated isoforms of Skp1.
Simultaneous measurement of refractive index and temperature based on intensity demodulation using matching grating method.
Jin et al., Hangzhou, China. In Rev Sci Instrum, 2013
The reflective peaks of two fiber Bragg gratings (FBGs), one of which is etched then sensitive to both SRI and temperature, another (FBG2) is only sensitive to temperature, were located in the same linear range of the LPG-PCF's transmission spectrum.
A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins.
Lederkremer et al., Tel Aviv-Yafo, Israel. In J Biol Chem, 2013
Similar to an established glycosylated ERAD substrate, the uncleaved precursor of asialoglycoprotein receptor H2a, its nonglycosylated mutant, makes use of calnexin, EDEM1, and HRD1, but only glycosylated H2a is a substrate for the cytosolic SCF(Fbs2) E3 ubiquitin ligase with lectin activity.
Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex.
Yan et al., Buffalo, United States. In Neuron, 2012
All these effects relied on activation of glucocorticoid receptors and the subsequent enhancement of ubiquitin/proteasome-mediated degradation of GluR1 and NR1 subunits, which was controlled by the E3 ubiquitin ligase Nedd4-1 and Fbx2, respectively.
Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.
Wang et al., Shanghai, China. In J Proteome Res, 2012
systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions.
The Nogo receptor 2 is a novel substrate of Fbs1.
Lindner et al., Innsbruck, Austria. In Biochem Biophys Res Commun, 2012
To learn more about the interactome of NgR2 we performed pull down experiments and were able to identify F-box protein that recognizes sugar chain 1 (Fbs1) as binding partner.
SPPS: a sequence-based method for predicting probability of protein-protein interaction partners.
Zhang et al., Shanghai, China. In Plos One, 2011
Two interacting proteins of human FBXO6 protein have been found using the service in the study.
Skp1 stabilizes the conformation of F-box proteins.
Tanaka et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
We have reported previously that Fbs1 and Fbs2 are N-linked glycoprotein-specific F-box proteins.
Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps.
Lederkremer et al., Tel Aviv-Yafo, Israel. In J Biol Chem, 2011
In contrast, substrate association with XTP3-B and with the E3 ubiquitin ligases HRD1 and SCF(Fbs2) was inhibited.
SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function.
Pasinetti et al., New York City, United States. In Aging Cell, 2010
We report that the SCF(Fbx2) -E3 ligase is involved in the binding and ubiquitination of BACE1 via its Trp 280 residue of F-box-associated domain.
FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest.
Glenn et al., Iowa City, United States. In Cell Cycle, 2010
FBG1 is unique among known F-box proteins in that it contains a non-canonical D-Box within F-box domain, required for the growth arrest.
Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex.
Yamane et al., Nagoya, Japan. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
Fbs1, an F-box protein, binds specifically to proteins modified with high-mannose oligosaccharides.
Conformational stabilities of guinea pig OCP1 and OCP2.
Henzl et al., Columbia, United States. In Biophys Chem, 2009
OCP1 is equivalent to the F-box protein known as Fbs1, Fbx2, or NFB42 - previously shown to bind N-glycosylated proteins and believed to function in the retrieval and recycling of misfolded proteins.
The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation.
Nussinov et al., Frederick, United States. In Plos Comput Biol, 2009
Here, we simulated nine substrate binding proteins: Skp2, Fbw7, beta-TrCP1, Cdc4, Fbs1, TIR1, pVHL, SOCS2, and SOCS4, in the unbound form and bound to Skp1, ASK1 or Elongin C. All nine proteins have two domains: one binds to the substrate; the other to E3 ligase modules Skp1/ASK1/Elongin C. We discovered that in all cases the flexible inter-domain linker serves as a hinge, rotating the substrate binding domain, optimally and accurately positioning it for ubiquitin transfer.
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.
Hunter et al., Cleveland, United States. In Mol Cell, 2009
Fbx6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this mechanism might increase tumor cell resistance to certain anticancer drugs.
A study on the functions of ubiquitin metabolic system related gene FBG2 in gastric cancer cell line.
Li et al., Beijing, China. In J Exp Clin Cancer Res, 2008
BACKGROUND: FBG2 (F-BOX6) gene is an important member in ubiquitin metabolic system F-BOX family, and forms E3 complex with the other members in the family.
F-box proteins that contain sugar-binding domains.
Yoshida, Tokyo, Japan. In Biosci Biotechnol Biochem, 2007
Among theses, Fbs1 and Fbs2 are perhaps involved in the endoplasmic reticulum-associated degradation pathway.
Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit.
Paulson et al., Iowa City, United States. In J Neurosci, 2007
Our findings demonstrate that components of protein quality control are essential for inner ear homeostasis and implicate Fbx2 and Skp1 as potential genetic modifiers in age-related hearing loss.
E3 ubiquitin ligase that recognizes sugar chains.
Tai et al., Tokyo, Japan. In Nature, 2002
Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex.
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