The Nogo receptor 2 is a novel substrate of Fbs1.
Innsbruck, Austria. In Biochem Biophys Res Commun, 2012
To learn more about the interactome of NgR2 we performed pull down experiments and were able to identify F-box protein that recognizes sugar chain 1 (Fbs1) as binding partner.
Conformational stabilities of guinea pig OCP1 and OCP2.
Columbia, United States. In Biophys Chem, 2009
OCP1 is equivalent to the F-box protein known as Fbs1, Fbx2, or NFB42 - previously shown to bind N-glycosylated proteins and believed to function in the retrieval and recycling of misfolded proteins.
The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation.
Frederick, United States. In Plos Comput Biol, 2009
Here, we simulated nine substrate binding proteins: Skp2, Fbw7, beta-TrCP1, Cdc4, Fbs1, TIR1, pVHL, SOCS2, and SOCS4, in the unbound form and bound to Skp1, ASK1 or Elongin C. All nine proteins have two domains: one binds to the substrate; the other to E3 ligase modules Skp1/ASK1/Elongin C. We discovered that in all cases the flexible inter-domain linker serves as a hinge, rotating the substrate binding domain, optimally and accurately positioning it for ubiquitin transfer.