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F-box and leucine-rich repeat protein 2

FBL-3
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: Fib, HAD, CAN, Interleukin-2, MHC
Papers on FBL-3
CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity.
New
Dittmer et al., Essen, Germany. In J Immunol, Feb 2016
In this study, we used the highly immunogenic Friend virus-induced FBL-3 tumor as a model to study the mechanisms of immunological tumor control by CD4(+) T cells in the course of CD137 (4-1BB) agonist immunotherapy in the absence of a CD8 T cell response.
Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant.
New
Wang et al., Shanghai, China. In Int J Mol Med, Jul 2015
In the present study, we co‑cultured C57BL/6 mouse bone marrow (BM)‑derived MSCs with A20 murine B lymphoma, FBL3 murine erythroleukemia and P388 murine acute lymphocytic leukemia cells.
A novel cancer immunotherapy based on the combination of a synthetic carbohydrate-pulsed dendritic cell vaccine and glycoengineered cancer cells.
New
Zhang et al., Shanghai, China. In Oncotarget, Apr 2015
The results showed that this strategy could significantly inhibit FBL3 tumor growth and prolong the survival of tumor-bearing mice; B16F10 lung metastases could also be reduced.
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Dittmer et al., Essen, Germany. In Cancer Immunol Immunother, 2013
In the current research, we have used a murine retrovirus-induced tumor cell line of C57BL/6 mouse origin, namely FBL-3 cells, as a model to study basic mechanisms of immunological control and escape during tumor formation.
Effects of ICOSLG expressed in mouse hematological neoplasm cell lines in the GVL reaction.
Wang et al., Shanghai, China. In Bone Marrow Transplant, 2013
In our study, we analyzed the expression of ICOSLG in six mice hematological malignancy cell lines for the first time, and found that FBL3, A20 and P388 cells expressed high levels of ICOSLG.
Combining synthetic carbohydrate vaccines with cancer cell glycoengineering for effective cancer immunotherapy.
Guo et al., Shanghai, China. In Cancer Immunol Immunother, 2012
Using a murine leukemia model FBL3 with GM3 antigen as the target, it was shown that artificial GM3 N-phenylacetyl derivative (GM3NPhAc) elicited robust antigen-specific T cell-dependent immunity and that N-phenylacetyl-D-mannosamine (ManNPhAc) as the biosynthetic precursor of GM3NPhAc selectively glycoengineered cancer cells to express GM3NPhAc both in vitro and in vivo.
Anti-tumor immune responses in immune-reconstituted mice injected with a tumor vaccine.
Chao et al., Xi'an, China. In Med Oncol, 2012
Mice were then injected with an inactivated FBL-3 tumor cell vaccine and challenged with FBL-3 tumor cells.
F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest.
GeneRIF
Mallampalli et al., Pittsburgh, United States. In Oncogene, 2012
FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor
Expression of ICOSLG on mouse hematologic neoplasm cell lines and their influence on cytotoxicity in allogeneic mixed lymphocyte reactions.
Wang et al., Shanghai, China. In Leuk Lymphoma, 2012
Using flow cytometry, we examined the expression of ICOSLG in mouse hematologic neoplasm cell lines for the first time and used FBL3/A20 as targets to study.
F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.
GeneRIF
Mallampalli et al., Pittsburgh, United States. In Blood, 2012
FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.
FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis.
GeneRIF
Horiguchi et al., Zürich, Switzerland. In J Neurosci, 2012
FBL2 is a novel and dual regulator of amyloid precursor protein (APP) metabolism through FBL2-dependent ubiquitination of APP.
Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation.
Strober et al., Stanford, United States. In Blood, 2011
WT1 peptide vaccinations of healthy donor mice induced CD8(+) T cells that were specifically reactive to WT1-expressing FBL3 leukemia cells.
FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
GeneRIF
Mallampalli et al., Pittsburgh, United States. In Cell Cycle, 2011
FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
[Establishment of an erythroleukemia model in CB6F1 mice by transplant with haploidentical mouse leukemic cell line FBL-3].
Wu et al., Zhengzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010
The purpose of study was to investigate the feasibility for establishing erythroleukemia model in CB6F1 mice by transplant with haploidentical mouse leukemic cell line FBL-3 and to explore the biological characteristics of FBL-3 cells in CB6F1 mice, CB6F1 and C57BL/6 mice were inoculated intravenously at doses of 1×10(3)-1×10(7) FBL-3 cells respectively.
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire.
Greenberg et al., Southampton, United Kingdom. In Eur J Immunol, 2008
Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLV(gag) antigen and protected against leukemia challenge in vivo.
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
Impact
GeneRIF
Pagano et al., New York City, United States. In Science, 2007
study demonstrates that the SCF(Fbxl3)ubiquitin ligase controls the oscillations of the circadian clock by mediating the degradation of Cry1 and Cry2 proteins
The ex vivo microenviroments in MLTC of poorly immunogenic tumor cells facilitate polarization of CD4+CD25+ regulatory T cells.
Wang et al., Xi'an, China. In Cell Mol Immunol, 2006
In order to investigate the tumor immune microenvironment and its influence on TR polarization, poorly immunogenic tumor cell line D5 (C57BL/6, H-2b), immunogenic tumor cell lines FBL3 (C57BL/6, H-2b) and H22 BALB/c, H-2d) were used to establish the syngeneic/allogeneic, poorly immunogenic/immunogenic mixed lymphocytes-tumor cell culture (MLTC).
Effects of anesthesia-induced modest hypothermia on cellular radiation sensitivity.
Cao et al., Shanghai, China. In Sci China C Life Sci, 2002
The MH exerted similar protective effects on the leukemia cell lines A20, HL60, K562 to the normal bone marrow cells, but it enhanced the radiation sensitivity of leukemia cell line FBL3 and mouse melanoma B16F10.
Immune activation of erythroleukemia cells induced by interleukin 12.
Xuetao et al., Shanghai, China. In Sci China C Life Sci, 1998
To investigate the antitumor activity of IL-12, the induction of differentiation of IL-12 was observed using erythroleukemia cells (FBL-3) as model.
Murine lymphoma-induced immunosuppression: requirement for direct tumour cell contact.
Impact
Friedman et al., In Science, 1978
The FBL-3 lymphoma cell line caused impaired antibody formation in vivo when injected into mice intraperitoneally, and in vitro when added to normal syngeneic spleen cells immunized in vitro with sheep erythrocytes.
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