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Fbh1 DNA helicase I

Fbh1, F-box DNA helicase 1
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rad51, CAN, Blm, Ubiquitin, Atm
Papers on Fbh1
BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.
New
Stewart et al., Birmingham, United Kingdom. In Mol Cell, Sep 2015
Blocking DNA2-dependent resection, or downregulation of the helicases BLM and FBH1, suppresses both catastrophic fork processing and the accumulation of chromosomal damage in BOD1L-deficient cells.
FBH1 Catalyzes Regression of Stalled Replication Forks.
New
Sørensen et al., Copenhagen, Denmark. In Cell Rep, Apr 2015
Here, we show that FBH1 catalyzes regression of a model replication fork in vitro and promotes fork regression in vivo in response to replication perturbation.
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
Hickson et al., Oxford, United Kingdom. In Nat Commun, 2014
The F-box DNA helicase 1 (FBH1) is a 3'-5' DNA helicase with a putative function as a negative regulator of HR.
Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability.
Review
Brosh et al., Baltimore, United States. In Biomolecules, 2014
Other work provides evidence that degradation of the F-box DNA helicase (FBH1) helps to balance translesion synthesis (TLS) and homologous recombination (HR) repair at blocked replication forks.
FBH1 affects warm temperature responses in the Arabidopsis circadian clock.
Kay et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2014
In this report, we characterized this transcription factor, flowering basic helix-loop-helix 1 (FBH1) that binds in vivo to the promoter of the key clock gene circadian clock-associated 1 (CCA1) and regulates its expression.
Rad51 overexpression and resistance to genotoxic agents. A study in the fission yeast Schizosaccharomyces pombe.
Petrescu-Danila et al., In Rev Med Chir Soc Med Nat Iasi, 2014
However, when overexpression was associated with the deletion of the helicase-encoding fbh1 gene, the sensitivity to camptothecin was diminished.
FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.
Hickson et al., Praha, Czech Republic. In J Biol Chem, 2013
Using a combination of molecular genetic, biochemical, and single-molecule biophysical techniques, we provide mechanistic insight into the mode of action of the FBH1 helicase as a regulator of RAD51-dependent HR in mammalian cells.
The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells.
Kannouche et al., Villejuif, France. In Nucleic Acids Res, 2013
Among them, the helicase FBH1 accumulates at sites of DNA damage and potentially constrains HR via its anti-recombinase activity.
FBH1 protects melanocytes from transformation and is deregulated in melanomas.
Pagano et al., New York City, United States. In Cell Cycle, 2013
FBH1 is a member of the UvrD family of DNA helicases and plays a crucial role in the response to DNA replication stress.
Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase.
Spies et al., Urbana, United States. In Nucleic Acids Res, 2013
This methodology was applied to visualize human DNA helicase F-box-containing DNA helicase (FBH1) acting on the DNA structures resembling a stalled or collapsed replication fork and its interactions with RAD51 nucleoprotein filament.
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.
Pagano et al., New York City, United States. In J Cell Biol, 2013
Purification of FBH1, a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), the major cellular single-stranded DNA (ssDNA)-binding protein complex.
FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
Sørensen et al., Copenhagen, Denmark. In Nat Commun, 2012
Here, we identify a key role for the FBH1 helicase in mediating DNA double-strand break formation following replication inhibition.
FLOWERING BHLH transcriptional activators control expression of the photoperiodic flowering regulator CONSTANS in Arabidopsis.
Imaizumi et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2012
Here we report the identification of four CO transcriptional activators, named FLOWERING BHLH 1 (FBH1), FBH2, FBH3, and FBH4.
SCF ensures meiotic chromosome segregation through a resolution of meiotic recombination intermediates.
GeneRIF
Yamamoto et al., Tokyo, Japan. In Plos One, 2011
SCF/Skp1 together with Fbh1 is likely to function in the resolution of meiotic recombination intermediates, thereby ensuring proper chromosome segregation.
A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations.
GeneRIF
Whitby et al., Oxford, United Kingdom. In Nucleic Acids Res, 2011
Fbh1 also serves a vital meiotic role in fission yeast to promote normal chromosome segregation.
The role of DNA helicases and their interaction partners in genome stability and meiotic recombination in plants.
Review
Puchta et al., Karlsruhe, Germany. In J Exp Bot, 2011
While no FBH1 homologue is present, the Arabidopsis genome contains homologues of both SRS2 and RTEL1.
Stress-induced phosphorylation of S. pombe Atf1 abrogates its interaction with F box protein Fbh1.
GeneRIF
Wilkinson et al., Manchester, United Kingdom. In Curr Biol, 2010
a version of Atf1 lacking all intact MAPK sites still interacts with Fbh1 upon stress, indicating that the association between the F box protein and substrate is disrupted by stress-induced phosphorylation
Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities.
GeneRIF
Mailand et al., Copenhagen, Denmark. In J Cell Biol, 2009
Data show that the human Fbh1 (hFbh1) helicase accumulates at sites of DNA damage or replication stress in a manner dependent fully on its helicase activity and partially on its conserved F box.
Fbh1 limits Rad51-dependent recombination at blocked replication forks.
GeneRIF
Whitby et al., Oxford, United Kingdom. In Mol Cell Biol, 2009
Data show that the F-box DNA helicase (Fbh1) functions in direct opposition to the Rad52 orthologue Rad22 to curb Rad51 loading onto DNA in fission yeast.
Structure of gene coding for the fruit body-specific hydrophobin Fbh1 of the edible basidiomycete Pleurotus ostreatus.
Pisabarro et al., Pamplona, Spain. In Mycologia, 2004
Two fruit body-specific hydrophobins (Fbh1 and POH1) have been identified in two different strains of the edible basidiomycete Pleurotus ostreatus.
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