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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fatty acid synthase

fatty acid synthase
plays a role in lipid biosynthesis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, Insulin, Sterol Regulatory Element Binding Protein 1, HAD, V1a
Papers on fatty acid synthase
Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA.
New
Heart et al., Cayey, Puerto Rico. In Am J Physiol Endocrinol Metab, Feb 2016
This protective action was associated with the TQ-dependent normalization of chronic accumulation of malonyl CoA, and elevation of acetyl CoA carboxylase (ACC), fatty acid synthase (FAS) and fatty acid binding proteins (FABPs) following chronic glucose overload.
Effects of dietary phosphate on glucose and lipid metabolism.
New
Taketani et al., Tokushima, Japan. In Am J Physiol Endocrinol Metab, Feb 2016
In addition, HP group also showed suppressed expression of hepatic lipogenic genes including sterol regulatory element binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase, whereas there was no difference in hepatic fat oxidation among the groups.
Evolutionary distinctiveness of fatty acid and polyketide synthesis in eukaryotes.
New
Murray et al., Sydney, Australia. In Isme J, Feb 2016
The phylogeny of fatty acid synthase genes reflects the evolutionary history of the organism, indicating selection to maintain conserved functionality.
Expression of lipid metabolism-related proteins in breast phyllodes tumors.
New
Koo et al., In Neoplasma, Feb 2016
Immunohistochemical staining for lipid metabolism-related proteins, namely hormone-sensitive lipase (HSP), perilipin 2, fatty-acid-binding proteins 4 (FABP4), Carnitine palmitoyltransferase-1 (CPT-1), acyl-CoA oxidase 1 (ACOX-1), and fatty acid synthase (FASN) was performed, and the immunohistochemical staining results were analyzed with respect to clinicopathologic parameters.
Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease.
New
Kim et al., Seoul, South Korea. In Nutr Res, Jan 2016
The transcriptional factors of hepatic lipogenesis, such as adiponectin, AMP-activated protein kinase α, sterol regulatory element-binding protein 1c, fatty acid synthase, carnitine palmitoyltransferase 1, 3-hydroxy-3-methyl-glutaryl-CoA reductase, and apolipoprotein B, as well as proinflammatory mediators, such as tumor necrosis factor α, nuclear factor κB, and caspase-3, improved in both experimental groups (P < .05).
Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease.
Review
New
Li et al., Nanjing, China. In Nutrients, Dec 2015
We also review the involvement of the mucus barrier in the exacerbation of the disease and explore the therapeutic potential of modifying the mucus barrier with short-chain fatty acids, prebiotics, probiotics, fatty acid synthase, H₂S, neutrophil elastase inhibitor and phophatidyl choline.
Progress in the development of fatty acid synthase inhibitors as anticancer targets.
Review
New
Yet et al., Mobile, United States. In Bioorg Med Chem Lett, Nov 2015
Fatty acid synthase (E.C. 2.3.1.85;
Different origin of adipogenic stem cells influences the response to antiretroviral drugs.
Review
New
Cossarizza et al., Modena, Italy. In Exp Cell Res, Nov 2015
CCAAT/enhancer-binding protein alpha (CEBPα) and peroxisome proliferator-activated receptor gamma (PPARγ), and in adipocyte functions, i.e. fatty acid synthase (FASN), fatty acid binding protein-4 (FABP4), perilipin-1 (PLIN1) and 1-acylglycerol-3-phosphate O-acyltransferase-2 (AGPAT2), were quantified by real time PCR.
Chalcone scaffolds as anti-infective agents: structural and molecular target perspectives.
Review
New
Asati et al., Bilāspur, India. In Eur J Med Chem, Sep 2015
Several natural and (semi) synthetic chalcones deserve the credit of being potential anti-infective candidates that inhibit various parasitic, malarial, bacterial, viral, and fungal targets like cruzain-1/2, trypanopain-Tb, trans-sialidase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), fumarate reductase, falcipain-1/2, β-hematin, topoisomerase-II, plasmepsin-II, lactate dehydrogenase, protein kinases (Pfmrk and PfPK5), and sorbitol-induced hemolysis, DEN-1 NS3, H1N1, HIV (Integrase/Protease), protein tyrosine phosphatase A/B (Ptp-A/B), FtsZ, FAS-II, lactate/isocitrate dehydrogenase, NorA efflux pump, DNA gyrase, fatty acid synthase, chitin synthase, and β-(1,3)-glucan synthase.
Marine Microbial Secondary Metabolites: Pathways, Evolution and Physiological Roles.
Review
Verde et al., Napoli, Italy. In Adv Microb Physiol, 2014
Discovery of new evolutionary links between the polyketide synthase and fatty acid synthase pathways may help to understand the selective advantages that led to evolution of secondary-metabolite biosynthesis within bacteria.
Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal.
Impact
Noel et al., Liège, Belgium. In Cell Metab, 2014
Interestingly, pharmacological lipogenesis inhibition with orlistat or fatty acid synthase downregulation with shRNA inhibited tumor regrowth and metastases after sunitinib treatment withdrawal.
Structure of a modular polyketide synthase.
Impact
Skiniotis et al., Ann Arbor, United States. In Nature, 2014
Here we used electron cryo-microscopy to determine sub-nanometre-resolution three-dimensional reconstructions of a full-length PKS module from the bacterium Streptomyces venezuelae that revealed an unexpectedly different architecture compared to the homologous dimeric mammalian fatty acid synthase.
A single gene affects both ecological divergence and mate choice in Drosophila.
Impact
Carroll et al., Madison, United States. In Science, 2014
We identify a fatty acid synthase mFAS (CG3524) responsible for mbCHC production in Drosophila and find that expression of mFAS is undetectable in oenocytes (cells that produce CHCs) of a closely related, desiccation-sensitive species, D. birchii, due in part to multiple changes in cis-regulatory sequences of mFAS.
Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.
Impact
Burkart et al., Irvine, United States. In Nature, 2014
Acyl carrier protein (ACP) transports the growing fatty acid chain between enzymatic domains of fatty acid synthase (FAS) during biosynthesis.
Lipid metabolism greases the stem cell engine.
Impact
Terzic et al., Rochester, United States. In Cell Metab, 2013
(2012) now demonstrate that regulation of lipogenesis by fatty acid synthase and Spot14-dependent malonyl-CoA supply determines the proliferative activity of resident neural stem cells, contributing to adult neurogenesis.
Weight gain induced by an isocaloric pair-fed high fat diet: a nutriepigenetic study on FASN and NDUFB6 gene promoters.
GeneRIF
Milagro et al., Pamplona, Spain. In Mol Genet Metab, 2010
Epididymal adipose tissue expression of the fatty acid synthase (FASN) gene and NADH dehydrogenase (ubiquinone) 1beta-subcomplex 6 (NDUFB6) were significantly reduced in the high fat diet group
Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
GeneRIF
Simmen et al., Little Rock, United States. In Am J Physiol Gastrointest Liver Physiol, 2008
Dietary soy protein, by decreasing circulating insulin levels and colon FASN expression, attenuates insulin-induced DNA damage and FASN-mediated anti-apoptosis during carcinogenesis.
Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways.
GeneRIF
Farrell et al., Canberra, Australia. In J Hepatol, 2008
There were reduced nuclear levels of the lipogenic transcription factor sterol regulatory element binding protein-1 in MCD-fed mice, but no consistent reduction in fatty acid synthesis genes (acetyl-CoA carboxylase and fatty acid synthase).
The novel inhibitory effect of Pangdahai on fatty acid synthase.
GeneRIF
Zhang et al., Beijing, China. In Iubmb Life, 2008
Results describe the inhibition of fatty acid synthase by flavonoids extracted from Pangdahai (Sterculia).
Catalytic residues are shared between two pseudosubunits of the dehydratase domain of the animal fatty acid synthase.
GeneRIF
Smith et al., Oakland, United States. In Chem Biol, 2007
Findings establish that sequence elements previously assigned to a central structural core region of the type I fatty acid synthases and some modular polyketide synthase counterparts play an essential catalytic role as part of the dehydratase domain.
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