fatty acid elongase
Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis.
Seattle, United States. In Carcinogenesis, Jan 2016
Among individuals with distant-metastatic CRC, several SNPs at 6p12.1, nearest the ELOVL5 gene, were statistically significantly associated with poorer survival, with the strongest associations noted for rs209489 [hazard ratio (HR) = 1.8, P = 7.6×10(-10) and HR = 1.8, P = 3.7×10(-9) for CRC-specific and overall survival, respectively).
Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations.
Oslo, Norway. In Oncotarget, Jan 2016
By combining genomic and transcriptomic analysis, certain recurrent rearrangements were identified and further validated in patient biopsies, including a PMP22-ELOVL5 gene fusion, genomic structural variations affecting RB1, MTAP/CDKN2A and MDM2, and, most frequently, rearrangements involving TP53.
Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue.
Astana, Kazakhstan. In Surg Obes Relat Dis, Aug 2015
RESULTS: Microarray analysis revealed that the overexpressed differentially expressed genes have a prominent role in the pathways involved in biosynthetic processes, especially lipid or carboxylic ones (stearoyl-Coenzyme A desaturase-1, fatty acid desaturase-1, fatty acid elongase-6, ATP citrate lyase, fatty acid synthase, lipin-1, monoacylglycerol O-acyltransferase, patatin-like phospholipase domain containing-3, phosphate cytidylyltransferase-2, cholesteryl ester transfer protein, transmembrane 7 superfamily member 2, pyruvate carboxylase, and glycogen synthase 2).
MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM--anabolic implants and meat quality.
Saint Kitts and Nevis. In J Anim Sci, 2014
The impact of anabolic implants on gene expression has shown that implanting downregulates expression of certain lipogenic genes (e.g., stearoyl-CoA desaturase, fatty acid synthetase, fatty acid elongase-6) in steers with low quality grades (Select-) but not in implanted steers with high quality grades (Choice-).
Extending the story of very-long-chain fatty acid elongation.
Vancouver, Canada. In Plant Sci, 2013
More broadly, the stoichiometry and quaternary structure of the fatty acid elongase complex remains poorly understood, and specific phylogenetic and biochemical questions persist for each component of the complex.
Rationale for a natural products approach to herbicide discovery.
United States. In Pest Manag Sci, 2012
The so-called 'new chemistries' are simply molecules belonging to new chemical classes that have the same mechanisms of action as older herbicides (e.g. the protoporphyrinogen-oxidase-inhibiting pyrimidinedione saflufenacil or the very-long-chain fatty acid elongase targeting sulfonylisoxazoline herbicide pyroxasulfone).
Fatty acid regulation of hepatic lipid metabolism.
Corvallis, United States. In Curr Opin Clin Nutr Metab Care, 2011
Moreover, loss-of-function and gain-of-function studies have identified fatty acid elongase (Elovl5), a key enzyme involved in PUFA synthesis, as a regulator of hepatic lipid and carbohydrate metabolism.
A genome-wide perspective of genetic variation in human metabolism.
München, Germany. In Nat Genet, 2010
For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes or solute carriers whose functions match the associating metabolic traits.