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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ELOVL family member 5, elongation of long chain fatty acids

fatty acid elongase, ELOVL5, ELOVL2, HELO1
ELOVL5 plays a role in elongation of long-chain polyunsaturated fatty acids (Leonard et al., 2000 [PubMed 10970790]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, FADS1, delta-6-desaturase
Papers on fatty acid elongase
Genome-wide meta-analyses identify novel loci associated with n-3 and n-6 polyunsaturated fatty acid levels in Chinese and European-ancestry populations.
Lin et al., Shanghai, China. In Hum Mol Genet, Feb 2016
We also confirmed previously reported loci including FADS1, NTAN1, NRBF2, ELOVL2 and GCKR Different effect sizes in FADS1 and independent association signals in ELOVL2 were observed.
Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis.
Newcomb et al., Seattle, United States. In Carcinogenesis, Jan 2016
Among individuals with distant-metastatic CRC, several SNPs at 6p12.1, nearest the ELOVL5 gene, were statistically significantly associated with poorer survival, with the strongest associations noted for rs209489 [hazard ratio (HR) = 1.8, P = 7.6×10(-10) and HR = 1.8, P = 3.7×10(-9) for CRC-specific and overall survival, respectively).
Inferring chronological age from DNA methylation patterns of human teeth.
Luiselli et al., Bologna, Italy. In Am J Phys Anthropol, Jan 2016
METHODS: We used MALDI-TOF mass spectrometry to analyze DNA methylation levels of specific CpGs located in the ELOVL2, FHL2, and PENK genes.
Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations.
Meza-Zepeda et al., Oslo, Norway. In Oncotarget, Jan 2016
By combining genomic and transcriptomic analysis, certain recurrent rearrangements were identified and further validated in patient biopsies, including a PMP22-ELOVL5 gene fusion, genomic structural variations affecting RB1, MTAP/CDKN2A and MDM2, and, most frequently, rearrangements involving TP53.
Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion into Tissues in Eurasian Perch (Perca fluviatilis).
Kestemont et al., Namur, Belgium. In Lipids, Dec 2015
However, fads2 and elovl5 gene expression and FADS2 enzyme activity were comparable between the two groups.
Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.
Agbaga, Oklahoma City, United States. In Adv Exp Med Biol, Dec 2015
These lipids contain fatty acids with variable hydrocarbon chain lengths between C14-C40, either saturated or unsaturated, that are derived from diet, synthesized de novo, or elongated from shorter chain fatty acids by fatty acid elongase enzymes.
Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.
Keun et al., Nicosia, Cyprus. In Oncogene, Nov 2015
Within this cluster the cancer-associated and cardioprotective miR-22 was shown to repress fatty acid synthesis and elongation in tumour cells by targeting ATP citrate lyase and fatty acid elongase 6, as well as impairing mitochondrial one-carbon metabolism by suppression of methylene tetrahydrofolate dehydrogenase/cyclohydrolase.
Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue.
García-Fuentes et al., Astana, Kazakhstan. In Surg Obes Relat Dis, Aug 2015
RESULTS: Microarray analysis revealed that the overexpressed differentially expressed genes have a prominent role in the pathways involved in biosynthetic processes, especially lipid or carboxylic ones (stearoyl-Coenzyme A desaturase-1, fatty acid desaturase-1, fatty acid elongase-6, ATP citrate lyase, fatty acid synthase, lipin-1, monoacylglycerol O-acyltransferase, patatin-like phospholipase domain containing-3, phosphate cytidylyltransferase-2, cholesteryl ester transfer protein, transmembrane 7 superfamily member 2, pyruvate carboxylase, and glycogen synthase 2).
Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).
Sandberg et al., Göteborg, Sweden. In Nutrients, 2014
In 211 subjects, we investigated whether polymorphisms in the FADS gene cluster and the ELOVL2 gene were associated with allergy or PUFA composition in serum phospholipids in a Swedish birth-cohort sampled at birth and at 13 years of age; allergy was diagnosed at 13 years of age.
MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM--anabolic implants and meat quality.
Pratt et al., Saint Kitts and Nevis. In J Anim Sci, 2014
The impact of anabolic implants on gene expression has shown that implanting downregulates expression of certain lipogenic genes (e.g., stearoyl-CoA desaturase, fatty acid synthetase, fatty acid elongase-6) in steers with low quality grades (Select-) but not in implanted steers with high quality grades (Choice-).
Extending the story of very-long-chain fatty acid elongation.
Kunst et al., Vancouver, Canada. In Plant Sci, 2013
More broadly, the stoichiometry and quaternary structure of the fatty acid elongase complex remains poorly understood, and specific phylogenetic and biochemical questions persist for each component of the complex.
Rationale for a natural products approach to herbicide discovery.
Duke et al., United States. In Pest Manag Sci, 2012
The so-called 'new chemistries' are simply molecules belonging to new chemical classes that have the same mechanisms of action as older herbicides (e.g. the protoporphyrinogen-oxidase-inhibiting pyrimidinedione saflufenacil or the very-long-chain fatty acid elongase targeting sulfonylisoxazoline herbicide pyroxasulfone).
Genetic variation in fatty acid elongases is not associated with intermediate cardiovascular phenotypes or myocardial infarction.
Baylin et al., Providence, United States. In Eur J Clin Nutr, 2012
minor allele copies at rs2294867 associated with an increase in total and LDL cholesterol...number of minor allele copies at rs761179 associated with increase in total cholesterol... However, associations not replicated in independent populations.
Association between SRBD1 and ELOVL5 gene polymorphisms and primary open-angle glaucoma.
Tsukahara et al., Japan. In Invest Ophthalmol Vis Sci, 2011
Typical POAG associated with ELOVL5 gene polymorphism may have a late rather than an early onset.
Fatty acid regulation of hepatic lipid metabolism.
Jump, Corvallis, United States. In Curr Opin Clin Nutr Metab Care, 2011
Moreover, loss-of-function and gain-of-function studies have identified fatty acid elongase (Elovl5), a key enzyme involved in PUFA synthesis, as a regulator of hepatic lipid and carbohydrate metabolism.
ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice.
Jacobsson et al., Stockholm, Sweden. In J Lipid Res, 2011
heterozygous Elovl2(+/-) male mice exhibited haploinsufficiency, with reduced levels of C28:5 and C30:5n-6 PUFAs, which gave rise to impaired formation and function of haploid spermatides.
Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.
Sunyer et al., Barcelona, Spain. In Plos One, 2010
Not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele.
Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.
Jump et al., Corvallis, United States. In J Lipid Res, 2010
Results establish a link between fatty acid elongation and hepatic glucose metabolism and suggest a role for regulators of Elovl5 activity in the treatment of diet-induced hyperglycemia.
A genome-wide perspective of genetic variation in human metabolism.
Suhre et al., München, Germany. In Nat Genet, 2010
For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes or solute carriers whose functions match the associating metabolic traits.
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Yamada et al., Tsukuba, Japan. In Nat Med, 2007
Insulin resistance is often associated with obesity and can precipitate type 2 diabetes.
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