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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fatty acid amide hydrolase

fatty acid amide hydrolase, FAAH
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CB1, CAN, HAD, V1a
Papers on fatty acid amide hydrolase
Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in Lupus.
New
Mohan et al., Dallas, United States. In J Immunol, Feb 2016
Fatty acid amide hydrolase (FAAH), a gene in the minimal subcongenic interval generated through recombinant mapping, was found to be upregulated in Sle2(z) B cells by microarray analysis, Western blot, and functional assays.
The endocannabinoid system in the human granulosa cell line KGN.
New
Dehghani et al., Halle, Germany. In Mol Cell Endocrinol, Feb 2016
CB1, CB2, DAGL, FAAH, GPR55, MAGL, NAPE-PLD and TRPV1 were expressed without FSH-dependent effects.
Dysregulated peripheral endocannabinoid system signaling is associated with cognitive deficits in first-episode psychosis.
New
From the FLAMM-PEPs study - Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) et al., Barcelona, Spain. In J Psychiatr Res, Feb 2016
The short-term verbal memory correlated to the Diacylglycerol lipase (p = 0.043) and the fatty acid amide hydrolase (p = 0.026) expression.
Ligands for cannabinoid receptors, promising anticancer agents.
Review
New
Manayi et al., Tehrān, Iran. In Life Sci, Feb 2016
Therefore, modulation of endocannabinoid system by inhibition of fatty acid amide hydrolase (FAAH), the enzyme, which metabolized endocannabinoids, or application of multiple cannabinoid or cannabis-derived compounds, may be appropriate for the treatment of several cancer subtypes.
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.
New
Scarpelli et al., Genova, Italy. In Eur J Med Chem, Jan 2016
Concomitant blockade of fatty acid amide hydrolase (FAAH) enhances the therapeutic effects of the NSAIDs while attenuating their propensity to cause gastrointestinal injury.
The fatty acid amide hydrolase inhibitor URB597 modulates serotonin-dependent emotional behaviour, and serotonin1A and serotonin2A/C activity in the hippocampus.
New
Gobbi et al., Montréal, Canada. In Eur Neuropsychopharmacol, Jan 2016
UNASSIGNED: The fatty acid amide hydrolase (FAAH) inhibitor URB597 increases anandamide, resulting in antidepressant/anxiolytic-like activity, likely via CB1 receptor-mediated modulation of serotonin (5-HT) and norepinephrine (NE) neurotransmission.
Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014).
Review
New
Rivara et al., Parma, Italy. In Expert Opin Ther Pat, Nov 2015
INTRODUCTION: Fatty acid amide hydrolase (FAAH) is a key enzyme responsible for the degradation of the endocannabinoid anandamide.
A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.
Review
New
Piomelli et al., Genova, Italy. In Chemmedchem, Nov 2015
The endogenous levels of anandamide, an endocannabinoid mediator with analgesic and tissue-protective functions, are regulated by fatty acid amide hydrolase (FAAH).
Genetic Manipulation of the Endocannabinoid System.
Review
Zimmer, Bonn, Germany. In Handb Exp Pharmacol, 2014
The first gene deletions of the cannabinoid CB(1) receptor were described in the late 1990s, soon followed by CB(2) and FAAH mutations in early 2000.
The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review.
Review
Fowler, Umeå, Sweden. In Handb Exp Pharmacol, 2014
The endocannabinoids anandamide and 2-arachidonoylglycerol are metabolised by both hydrolytic enzymes (primarily fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL)) and oxygenating enzymes (e.g.
Chemical probes of endocannabinoid metabolism.
Review
Impact
Cravatt et al., Los Angeles, United States. In Pharmacol Rev, 2013
Anandamide and 2-AG signaling pathways in the nervous system are terminated by enzymatic hydrolysis mediated primarily by the serine hydrolases fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively.
Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes.
GeneRIF
Konje et al., Leicester, United Kingdom. In J Clin Endocrinol Metab, 2012
Cannabinoid receptors and endocannabinoid modulating enzymes were localized in fallopian tube epithelium by immunohistochemistry and showed reduced CB1 and FAAH expression in ectopic pregnancy
β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CB₂ receptors.
GeneRIF
Romero et al., Madrid, Spain. In Br J Pharmacol, 2012
Data suggest that deletion of FAAH in astrocytes exacerbates inflammatory response to beta-amyloid in process involving peroxisome proliferator-activated receptor (PPAR) alpha, PPAR-gamma, and TRPV1 (transient receptor potential cation channel V1).
Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain.
Review
Impact
Wurm et al., Paris, France. In Nat Rev Drug Discov, 2012
Stemming from the same pharmacological concept, fatty acid amide hydrolase (FAAH) inhibitors have also been found to have analgesic effects in pain models by preventing the breakdown of endogenous cannabinoids.
Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation.
GeneRIF
Kurland et al., New York City, United States. In Plos One, 2011
Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation.
Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.
GeneRIF
Tejani-Butt et al., New York City, United States. In Plos One, 2011
critical role for FAAH, the endocannabinoid system and BDNF in the genetic predisposition to depressive-like behavior in WKY rats
Characterization of serotonin neurotransmission in knockout mice: implications for major depression.
Review
GeneRIF
Gobbi et al., Montréal, Canada. In Rev Neurosci, 2011
This review presented that the FAAH knockout mice show a correlation between 5-HT firing rate and
Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications.
Review
Impact
Hollenberg et al., Ann Arbor, United States. In Pharmacol Rev, 2010
In that regard, inhibitors of the principal inactivating enzyme for anandamide, fatty acid amide hydrolase (FAAH), are currently in development for the treatment of pain and inflammation.
Advances in quantum and molecular mechanical (QM/MM) simulations for organic and enzymatic reactions.
Impact
Jorgensen et al., Auburn, United States. In Acc Chem Res, 2010
Also summarized in this Account are three specific QM/MM applications to biomolecular systems: (1) a recent study that clarified the mechanism for the reaction of 2-pyrone derivatives catalyzed by macrophomate synthase as a tandem Michael-aldol sequence rather than a Diels-Alder reaction, (2) elucidation of the mechanism of action of fatty acid amide hydrolase (FAAH), an unusual Ser-Ser-Lys proteolytic enzyme, and (3) the construction of enzymes for Kemp elimination of 5-nitrobenzisoxazole that highlights the utility of QM/MM in the design of artificial enzymes.
Attenuation of allergic contact dermatitis through the endocannabinoid system.
Impact
Zimmer et al., Bonn, Germany. In Science, 2007
In contrast, fatty acid amide hydrolase-deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin.
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