fatty acid amide hydrolase
Ligands for cannabinoid receptors, promising anticancer agents.
Tehrān, Iran. In Life Sci, Feb 2016
Therefore, modulation of endocannabinoid system by inhibition of fatty acid amide hydrolase (FAAH), the enzyme, which metabolized endocannabinoids, or application of multiple cannabinoid or cannabis-derived compounds, may be appropriate for the treatment of several cancer subtypes.
COX inhibitors: a patent review (2011 - 2014).
Roma, Italy. In Expert Opin Ther Pat, Dec 2015
Among the described compounds, selenium-containing coxibs inhibiting COX-2 and Akt, in addition to the multi-target biphenyl derivatives as dual inhibitors of COX and fatty acid amide hydrolase, are the most promising ones.
Chemical probes of endocannabinoid metabolism.
Los Angeles, United States. In Pharmacol Rev, 2013
Anandamide and 2-AG signaling pathways in the nervous system are terminated by enzymatic hydrolysis mediated primarily by the serine hydrolases fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively.
Advances in quantum and molecular mechanical (QM/MM) simulations for organic and enzymatic reactions.
Auburn, United States. In Acc Chem Res, 2010
Also summarized in this Account are three specific QM/MM applications to biomolecular systems: (1) a recent study that clarified the mechanism for the reaction of 2-pyrone derivatives catalyzed by macrophomate synthase as a tandem Michael-aldol sequence rather than a Diels-Alder reaction, (2) elucidation of the mechanism of action of fatty acid amide hydrolase (FAAH), an unusual Ser-Ser-Lys proteolytic enzyme, and (3) the construction of enzymes for Kemp elimination of 5-nitrobenzisoxazole that highlights the utility of QM/MM in the design of artificial enzymes.