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FAST kinase domains 2

This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: FasT, NRIF3, SET, ND6, ACID
Papers on FASTKD2
FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.
Hentze et al., Heidelberg, Germany. In Rna, Nov 2015
A mutation within one of these newly assigned FASTK RBPs, FASTKD2, causes a rare form of Mendelian mitochondrial encephalomyopathy.
FASTKD2 is associated with memory and hippocampal structure in older adults.
Saykin et al., Indianapolis, United States. In Mol Psychiatry, Oct 2015
Using a genome-wide screen, we discovered a novel association of a polymorphism in the pro-apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2; rs7594645-G) with better memory performance and replicated this finding in independent samples.
Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis.
Shoubridge et al., Montréal, Canada. In Cell Rep, Mar 2015
Investigation of four uncharacterized putative RNA-binding proteins-two RNA helicases, DHX30 and DDX28, and two proteins of the Fas-activated serine-threonine kinase (FASTKD) family, FASTKD2 and FASTKD5-demonstrated that both helicases and FASTKD2 are required for mitochondrial ribosome biogenesis.
Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes.
Liang et al., Phoenix, United States. In Neurobiol Aging, Feb 2015
We identified differentially expressed mitochondria-related genes including TRMT61B, FASTKD2, and NDUFA4L2, and using pathway and weighted gene coexpression analyses, we identified differentially expressed immune response genes.
Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain.
Samuels et al., New York City, United States. In Bmc Cancer, 2013
DIF-1 acts in a wide variety of breast cancer cells but not other cell types to repress the pro-apoptotic gene, FASTKD2.
Evaluation of the cell viability of human Wharton's jelly stem cells for use in cell therapy.
Alaminos et al., Granada, Spain. In Tissue Eng Part C Methods, 2012
In fact, gene expression analysis revealed that the average cell viability was significantly associated with genes with a function in apoptotic cell death, especially pro-apoptotic FASTKD2, BNIP3L genes and anti-apoptotic TNFAIP8 and BCL2L2 genes.
A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.
Samuels et al., New York City, United States. In Mol Cell Biol, 2011
regulation of FASTKD2 by NRIF3 and the DIF-1 complex acts as a novel death switch that selectively modulates apoptosis in breast cancer
Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration.
Anderson et al., Boston, United States. In Biochem Biophys Res Commun, 2010
Mutations in FASTKD2 have been linked to a mitochondrial encephalomyopathy that is associated with reduced cytochrome c oxidase activity, an essential component of the mitochondrial electron transport chain.
CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study.
Bouchard et al., Baton Rouge, United States. In Circ Cardiovasc Genet, 2010
CREB1 SNP rs2253206 had the strongest effect (5.45% of variance), followed by SNPs in the FASTKD2 (3.1%), MAP2 (2.6%), SPAG16 (2.1%), ERBB4 (3 SNPs approximately 1.4% each), IKZF2 (1.4%), and PARD3B (1.0%) loci.
FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency.
Zeviani et al., Milano, Italy. In Am J Hum Genet, 2008
mutation in a gene segregating with a peculiar mitochondrial encephalomyopathy associated with COX deficiency in skeletal muscle. FASTKD2 is localized in the mitochondrial inner compartment.
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