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proteins. Page last changed on 19 Aug 2016.
Fas-activated serine/threonine kinase
FasT, FAST kinase, Fas-activated serine/threonine kinase, FASTK
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
p21, CAN, FASTKD2, HAD, p53
Papers on
FasT
Exome-based case-control association study using extreme phenotype design reveals novel candidates with protective effect in diabetic retinopathy.
New
Carlsbad, United States. In Hum Genet, Feb 2016
Whole-exome sequencing of the entire cohort was followed by statistical analysis employing combined multivariate and collapsing methods at the gene level, to identify genes that are enriched for rare variants in cases vs. CONTROLS: Three genes (NME3, LOC728699, and FASTK) reached gene-based genome-wide significance at the 10(-08) threshold (p value = 1.55 × 10(-10), 6.23 × 10(-10), 3.21 × 10(-08), respectively).
FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.
New
Heidelberg, Germany. In Rna, Nov 2015
RNA interactome capture identified several disease-relevant RNA-binding proteins (RBPs) with noncanonical RNA-binding architectures, including all six members of the FASTK (FAS-activated serine/threonine kinase) family of proteins.
FASTKD2 is associated with memory and hippocampal structure in older adults.
New
Indianapolis, United States. In Mol Psychiatry, Oct 2015
Using a genome-wide screen, we discovered a novel association of a polymorphism in the pro-apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2; rs7594645-G) with better memory performance and replicated this finding in independent samples.
A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.
New
Genève, Switzerland. In Cell Rep, Mar 2015
Here, we report that a novel translational variant of Fas-activated serine/threonine kinase (FASTK) co-localizes with mitochondrial RNA granules and is required for the biogenesis of ND6 mRNA, a mitochondrial-encoded subunit of the NADH dehydrogenase complex (complex I).
miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK.
Changzhou, China. In Plos One, 2012
Fas-activated serine/threonine kinase (FASTK) was identified as a direct target of miR-106a-5p.
Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling.
Glendale, United States. In J Steroid Biochem Mol Biol, 2012
These novel VIPs include CXXC5, FASTK, NR4A1, TPM2, MYL3 and XIRP1.
Apoptosis-related mRNA expression profiles of ovarian cancer cell lines following cisplatin treatment.
Suwŏn, South Korea. In J Gynecol Oncol, 2011
The cisplatin-induced up-regulation of DAD1 in transcriptional and protein levels contributed to the cisplatin resistance of OVCAR-3, and the up-regulation of FASTK and TNFRSF11A in SKOV-3 resulted in its higher sensitivity to cisplatin than that of OVCAR-3.
Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration.
Boston, United States. In Biochem Biophys Res Commun, 2010
Fas-activated serine/threonine phosphoprotein (FAST) is the founding member of the FAST kinase domain-containing protein (FASTKD) family that includes FASTKD1-5.
Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.
GeneRIF
Boston, United States. In J Immunol, 2010
FAST expression on lung cells of hematopoietic origin is crucial in mediating lipopolysaccharide-induced neutrophil migration to the lung in transgenic FAST-deficient mice compared with wild type controls.
Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome.
Leiden, Netherlands. In Blood, 2009
We confirmed that the FASTK and SKAP1 genes, residing in loci with recurrent gain, demonstrated increased expression.
Identification of malignancy factors by analyzing cystic tumors of the pancreas.
Review
Heidelberg, Germany. In Pancreatology, 2008
siRNA silencing of the gene with the most prominent variation - the anti-apoptotic factor FASTK (Fas-activated serine/threonine kinase) - revealed a regulative effect on several genes known to be relevant to the development of tumors.
Myocardial gene expression of matched hibernating and control tissue from patients with ischemic left ventricular dysfunction.
München, Germany. In Heart Vessels, 2008
Besides the reported upregulation of beta-adrenergic receptor kinase-1 in heart failure, we observed new gene expression patterns, such as the upregulation of fas-activated serine/threonine kinase (FAST) or reduced expression of desmoplakin.
Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen.
Leicester, United Kingdom. In Cell Death Differ, 2008
Within this group of 20 kinases, some (ULK1, PDK1, MAP4K4) have been implicated previously in axonal events, but others (MAST2, FASTK, CKM and DGUOK) have not.
Report of a chimeric origin of transposable elements in a bovine-coding gene.
Ribeirão Preto, Brazil. In Genet Mol Res, 2007
From these chimeric genes, only the FAST kinase domains 3 (FASTKD3) gene, present on chromosome BTA 20, is a functional gene and showed evidence of the exaptation event.
Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing.
GeneRIF
Boston, United States. In Proc Natl Acad Sci U S A, 2007
Nuclear FAST can regulate the splicing of FGFR2 transcripts.
Expression analysis of PCNA gene in chronic myelogenous leukemia--combined application of siRNA silencing and expression arrays.
Praha, Czech Republic. In Leuk Res, 2007
The following genes were up-regulated: CDK inhibitors p21 and p19-INK4D, pro-apoptotic FAST kinase, fibronectin, etc.
Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.
GeneRIF
Madrid, Spain. In J Biol Chem, 2007
FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
The AP-2alpha transcription factor regulates tumor cell migration and apoptosis.
Torino, Italy. In Adv Exp Med Biol, 2006
By performing a whole genome microarray analysis of the tumor cells expressing AP-2alpha siRNA, we identified several AP-2alpha-regulated genes involved in apoptosis and migration such as FAST kinase, osteopontin, caspase 9, members of the TNF family, laminin alpha 1, collagen type XII, alpha 1, and adam.
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
GeneRIF
Boston, United States. In Mol Cell Biol, 2004
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1 regulated changes in protein expression.
