A C. elegans model for ether lipid biosynthesis and function.
Washington, D.C., United States. In J Lipid Res, Jan 2016
We isolated C. elegans strains carrying loss of function mutations in three genes encoding the proteins required for the initial three steps in the ether lipid biosynthetic pathway, FARD-1/FAR1, ACL-7/GNPAT and ADS-1/AGPS.
A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform.
Amsterdam, Netherlands. In Hum Mol Genet, Nov 2015
Three additional RCDP types, RCDP2-3-4, are caused, respectively, by mutations in GNPAT, AGPS and FAR1, encoding enzymes involved in plasmalogen biosynthesis.
Multifaceted roles of FHY3 and FAR1 in light signaling and beyond.
Beijing, China. In Trends Plant Sci, Jul 2015
FAR-RED ELONGATED HYPOCOTYLS3 (FHY3) and FAR-RED-IMPAIRED RESPONSE1 (FAR1), initially identified as crucial components of phytochrome A (phyA)-mediated far-red (FR) light signaling in Arabidopsis thaliana, are the founding members of the FAR1-related sequence (FRS) family of transcription factors present in most angiosperms.
Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis.
New Haven, United States. In Nat Cell Biol, 2011
Here, we show that in Arabidopsis thaliana, FHY3, FAR1 and HY5, three positive regulators of the phytochrome A signalling pathway, directly bind to the promoter of ELF4, a proposed component of the central oscillator, and activate its expression during the day, whereas the circadian-controlled CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn through physical interactions with these transcription-promoting factors.
Is START a switch?
New York City, United States. In Ciba Found Symp, 1991
FAR1 encodes an alpha-factor-dependent inhibitor of CLN function whose expression is markedly reduced at the time of START.