gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, CAN, HAD, ACID, P-cadherin
Papers on FAN
An epigenetic signal encoded protection mechanism is activated by graphene oxide to inhibit its induced reproductive toxicity in Caenorhabditis elegans.
Wang et al., Nanjing, China. In Biomaterials, Feb 2016
For the underlying molecular mechanism of reproductive toxicity of GO, we raised a signaling cascade of HUS-1/CLK-2-CEP-1-EGL-1-CED-4-CED-3 to explain the roles of core apoptosis signaling pathway and DNA damage checkpoints.
Enhancing anaerobic digestion of high-pressure extruded food waste by inoculum optimization.
He et al., Beijing, China. In J Environ Manage, Feb 2016
High ammonia concentration had a negative effect on CH4 production (i.e., when free ammonia nitrogen [FAN] increased from 20 to 30 mg L(-1) to 120-140 mg L(-1), the CH4 yield decreased by 25%), suggesting that FAN was a significant inhibitor in CH4 yield reduction.
Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.
Kawasaki et al., Seoul, South Korea. In J Cell Sci, Feb 2016
We further revealed that CEP-1, the p53 homolog, and the caspase CED-3 promoted elimination of PGL-1 from germ cells following UV irradiation.
Bioinformatics Analysis of Proteome Changes in Calu-3 Cell Infected by Influenza A Virus (H5N1).
Yang et al., Suzhou, China. In J Mol Microbiol Biotechnol, 2014
In the networks, we found 5 significant proteins including FAN, CPSF2, AGO1, AGO2 and PAX5.
Induction of cap-independent BiP (hsp-3) and Bcl-2 (ced-9) translation in response to eIF4G (IFG-1) depletion in C. elegans.
Keiper et al., Greenville, United States. In Translation (austin), 2013
In this study we address the translational regulation of the stress and apoptosis-related mRNAs in C. elegans: BiP (hsp-3) (hsp-4), Hif-1 (hif-1), p53 (cep-1), Bcl-2 (ced-9) and Apaf-1 (ced-4).
The TP53 signaling network in mammals and worms.
Derry et al., Toronto, Canada. In Brief Funct Genomics, 2013
C. elegans contains a single TP53 family member, cep-1, that shares properties of all three vertebrate genes and thus offers a simple system in which to study the biological functions of this important gene family.
Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction.
Perez-Vizcaino et al., Madrid, Spain. In J Cell Physiol, 2011
We propose an integrated signalling pathway for hypoxic pulmonary vasoconstriction which includes nSMase-PKCzeta-NADPH oxidase as a necessary step required for reactive oxygen species production.
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.
Hengartner et al., Zürich, Switzerland. In Nature, 2010
Here we show that Caenorhabditis elegans HIF-1 protects against DNA-damage-induced germ cell apoptosis by antagonizing the function of CEP-1, the homologue of the tumour suppressor p53.
A role for borg5 during trophectoderm differentiation.
Zheng et al., Baltimore, United States. In Stem Cells, 2010
report that differentiation of embryonic stem cells toward trophectoderm is accompanied by enhanced actin protrusion and cell motility that require upregulation of Borg5.
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.
Venables et al., London, United Kingdom. In Immunol Rev, 2010
Antibodies to citrullinated proteins are associated with HLA 'shared epitope' alleles, and autoimmunity to at least one antigenic sequence, the CEP-1 peptide from citrullinated alpha-enolase (KIHAcitEIFDScitGNPTVE), shows a specific association with HLA-DRB1*0401, *0404, 620W PTPN22, and smoking.
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.
Lundberg et al., Stockholm, Sweden. In Nat Genet, 2009
In 1,497 individuals from three RA cohorts, antibodies to the immunodominant citrullinated alpha-enolase CEP-1 epitope were detected in 43-63% of the anti-CCP-positive individuals, and this subset was preferentially linked to HLA-DRB1*04.
CB(1) cannabinoid receptors and their associated proteins.
Dalton et al., Winston-Salem, United States. In Curr Med Chem, 2009
Factor Associated with Neutral sphingomyelinase (FAN) regulates ceramide signaling.
FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.
Ségui et al., Toulouse, France. In J Immunol, 2009
these results indicate the involvement of FAN in TNF-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response.
The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior.
Kelley et al., Urbana, United States. In Psychopharmacologia, 2009
This is the first report to demonstrate that TNFalpha-induced sickness behavior is fully mediated by TNF-R1 and that the adaptor protein FAN is a necessary intracellular intermediate for sickness behavior
Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans.
Kolesnick et al., New York City, United States. In Science, 2008
These studies define CEP-1 (the worm homolog of the tumor suppressor p53)-mediated accumulation of EGL-1 and ceramide synthase-mediated generation of ceramide through parallel pathways that integrate at mitochondrial membranes to regulate stress-induced apoptosis.
Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells.
Hannun et al., Charleston, United States. In Mol Pharmacol, 2008
Regulation of NSMAF by TNF-alpha involves PRKCD in lung epithelial cells.
Translational regulation of p53 as a potential tumor therapy target.
Gartner et al., Rotterdam, Netherlands. In Future Oncol, 2006
The discovery of a worm p53 homolog cep-1/p53 (which stands for C. elegans p53) that specifically induces apoptosis upon DNA damage through a pathway that is conserved from worm to man opened the way for the use of C. elegans genetics to uncover regulatory mechanisms - and hence novel therapeutic targets - of p53-mediated apoptosis.
DNA repair.
Rose et al., Vancouver, Canada. In Wormbook, 2005
Both of these responses are regulated by checkpoint genes including mrt-2, hus-1, rad-5 and cep-1, the C. elegans ortholog of the human tumour suppressor p53.
Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.
Gartner et al., Martinsried, Germany. In Cell, 2005
C. elegans contains a primordial p53 gene, cep-1, that acts as a transcription factor necessary for DNA damage-induced apoptosis.
Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation.
Kolesnick et al., New York City, United States. In Nat Genet, 2004
Our findings delineate an apoptotic pathway antagonized by ABL-1, which requires sequentially the cell cycle checkpoint genes clk-2, hus-1 and mrt-2; the C. elegans p53 homolog, cep-1; and the genes encoding the components of the conserved apoptotic machinery, ced-3, ced-9 and egl-1.
share on facebooktweetadd +1mail to friends