The TP53 signaling network in mammals and worms.
Toronto, Canada. In Brief Funct Genomics, 2013
C. elegans contains a single TP53 family member, cep-1, that shares properties of all three vertebrate genes and thus offers a simple system in which to study the biological functions of this important gene family.
Translational regulation of p53 as a potential tumor therapy target.
Rotterdam, Netherlands. In Future Oncol, 2006
The discovery of a worm p53 homolog cep-1/p53 (which stands for C. elegans p53) that specifically induces apoptosis upon DNA damage through a pathway that is conserved from worm to man opened the way for the use of C. elegans genetics to uncover regulatory mechanisms - and hence novel therapeutic targets - of p53-mediated apoptosis.
Vancouver, Canada. In Wormbook, 2005
Both of these responses are regulated by checkpoint genes including mrt-2, hus-1, rad-5 and cep-1, the C. elegans ortholog of the human tumour suppressor p53.