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Family with sequence similarity 3, member C

FAM3C, ILEI, interleukin-like EMT inducer
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Wnt16, fibrillin-1, CAN, ORF9, Akt2
Papers on FAM3C
A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius.
New
Grant et al., Cincinnati, United States. In Hum Mol Genet, Oct 2015
Signals at the CPED1-WNT16-FAM3C locus have been previously associated with BMD at other skeletal sites in adults and children.
Prognostic significance of FAM3C in esophageal squamous cell carcinoma.
Guan et al., Guangzhou, China. In Diagn Pathol, 2014
BACKGROUND: Family with sequence similarity 3, member C (FAM3C) has been identified as a novel regulator in epithelial-mesenchymal transition (EMT) and metastatic progression.
Identification of secreted proteins that reflect autophagy dynamics within tumor cells.
Speicher et al., Philadelphia, United States. In Autophagy, 2014
These comparisons identified candidate autophagy biomarkers IL1B (interleukin 1, β), CXCL8 (chemokine (C-X-C motif) ligand 8), LIF (leukemia inhibitory factor), FAM3C (family with sequence similarity 3, member C), and DKK3 (dickkopf WNT signaling pathway inhibitor 3) with known roles in inflammation and tumorigenesis, and these proteins were subsequently shown to be elevated in supernatants of an independent panel of high-autophagy melanoma cell lines.
ILEI: a novel marker for epithelial-mesenchymal transition and poor prognosis in colorectal cancer.
Xu et al., Shenyang, China. In Histopathology, 2014
In this study, we investigated the expression of interleukin-like EMT inducer (ILEI) and EMT-associated markers (E-cadherin, vimentin) in CRC tissues and determined the correlations between ILEI expression and clinicopathological characteristics, prognosis and EMT in CRC.
SchA-p85-FAK complex dictates isoform-specific activation of Akt2 and subsequent PCBP1-mediated post-transcriptional regulation of TGFβ-mediated epithelial to mesenchymal transition in human lung cancer cell line A549.
Pan et al., Beijing, China. In Tumour Biol, 2014
A post-transcriptional pathway by which TGF-β modulates expression of specific proteins, Disabled-2 (Dab2) and Interleukin-like EMT Inducer (ILEI), inherent to epithelial to mesenchymal transition (EMT) in murine epithelial cells through Akt2-mediated phosphorylation of poly r(C) binding protein (PCBP1), has been previously elucidated.
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
Deng et al., Shanghai, China. In Hum Mol Genet, 2014
(FAM3C, WNT16), 8q24.12 (TNFRSF11B), 11p15.3
Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay.
Kim et al., Seoul, South Korea. In Ann Hematol, 2014
We identified a set of genes whose expression provided prognostic indicators from whole data set (PRKCDBP, CASP10, FAM3C, KCNK12, MAN1A2, PRND, RAB1A, TMEM39B, SLC6A6, MMP12, FEM1B, C3orh37, RBP1, HK1, LOC400464, KIAA0746, and SLC25A23).
ILEI drives epithelial to mesenchymal transition and metastatic progression in the lung cancer cell line A549.
Li et al., Beijing, China. In Tumour Biol, 2014
Here, we functionally validate a previously described post-transcriptional pathway by which TGF-β modulates expression of interleukin-like EMT inducer (ILEI), and EMT itself.
The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.
Nishimura et al., Ōtsu, Japan. In Nat Commun, 2013
Here we identify a secretory protein named interleukin-like epithelial-mesenchymal transition inducer (ILEI, also known as FAM3 superfamily member C) as a negative regulator of Aβ production.
Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression.
Beug et al., In Breast Cancer Res, 2013
INTRODUCTION: Interleukin-like epithelial-to-mesenchymal transition inducer (ILEI) is an essential cytokine in tumor progression that is upregulated in several cancers, and its altered subcellular localization is a predictor of poor survival in human breast cancer.
Family with sequence similarity 3 gene family and nonalcoholic fatty liver disease.
Review
Guan et al., Beijing, China. In J Gastroenterol Hepatol, 2013
The family with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members designated FAM3A, FAM3B, FAM3C, and FAM3D, respectively.
Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.
Review
Kiel et al., Boston, United States. In J Clin Endocrinol Metab, 2012
Among 59 novel BMD GWAS loci that have not been reported by previous candidate gene association studies, some have been shown to be involved in key biological pathways involving the skeleton, particularly Wnt signaling (AXIN1, LRP5, CTNNB1, DKK1, FOXC2, HOXC6, LRP4, MEF2C, PTHLH, RSPO3, SFRP4, TGFBR3, WLS, WNT3, WNT4, WNT5B, WNT16), bone development: ossification (CLCN7, CSF1, MEF2C, MEPE, PKDCC, PTHLH, RUNX2, SOX6, SOX9, SPP1, SP7), mesenchymal-stem-cell differentiation (FAM3C, MEF2C, RUNX2, SOX4, SOX9, SP7), osteoclast differentiation (JAG1, RUNX2), and TGF-signaling (FOXL1, SPTBN1, TGFBR3).
A follow-up association study of two genetic variants for bone mineral density variation in Caucasians.
GeneRIF
Deng et al., Beijing, China. In Osteoporos Int, 2012
At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD.
TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI.
Impact
GeneRIF
Howe et al., Cleveland, United States. In Nat Cell Biol, 2010
TGF-beta modulates the expression of Dab2 and ILEI mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT element in the 3'UTR of Dab2 and ILEI.
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
Impact
Kim et al., Seoul, South Korea. In Nat Genet, 2009
On chromosome 7q31, rs7776725 (within the FAM3C gene) was associated with bone density at the radius (P = 1.0 x 10(-11)), tibia (P = 1.6 x 10(-6)) and heel (P = 1.9 x 10(-10)).
Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy.
GeneRIF
Wang et al., Chongqing, China. In Brain Res, 2009
Data show that FAM3C is decreased in the CSF of temporal lobe epilepsy patients.
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.
GeneRIF
Mikulits et al., Vienna, Austria. In Oncogene, 2009
ILEI requires cooperation with oncogenic Ras to govern hepatocellular EMT through mechanisms involving PDGF-R/beta-catenin and PDGF-R/Stat3 signaling.
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.
Impact
GeneRIF
Beug et al., Vienna, Austria. In Cancer Cell, 2006
ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors.
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