La FAM fatale: USP9X in development and disease.
Brisbane, Australia. In Cell Mol Life Sci, Jun 2015
The ubiquitin-specific protease 9X (USP9X/FAM) is a substrate-specific DUB, which displays an extraordinarily high level of sequence conservation from Drosophila to mammals.
[Inherited retinal or optic nerve disorders – five steps to diagnosis].
Regensburg, Germany. In Klin Monbl Augenheilkd, Mar 2015
In addition to the basic ophthalmological examination, electrophysiological tests (ERG, n = 2,088, since 1986; EOG, n = 381, since 1986; VEP n = 595, since 1986; mfERG, n = 819, since 1998) and non-invasive retinal imaging (fundus autofluorescence (FAF, n = 1,784, since 2002), near-infrared autofluorescence (NIA, n = 1,091, since 2006), spectral domain OCT (SD-OCT, n = 848, since 2008) and three-wavelengths multicolour spectral reflection imaging (MC, n = 366, since 2013) were performed at least once.
Emerging frontiers in pancreatic cancer research: elaboration of key genes, cells and the extracellular milieu.
Ann Arbor, United States. In Curr Opin Gastroenterol, 2012
High-throughput sequencing of pancreatic ductal adenocarcinoma as well as neuroendocrine tumors and rarer subtypes of cancers of the pancreas has revealed several novel mutations in genes like PALB2, guanine nucleotide-binding protein, alpha stimulating, death-domain-associated protein, α thalassemia/mental retardation syndrome X linked, switch/sucrose nonfermentable pathway related, and in genes in the ubiquitin-dependent pathways such as USP9X.
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.
San Francisco, United States. In Nat Rev Mol Cell Biol, 2011
For example, ubiquitin E3 ligases, such as MDM2 (which ubiquitylates p53) and inhibitor of apoptosis (IAP) proteins, and deubiquitinases, such as A20 and ubiquitin-specific protease 9X (USP9X) (which regulate the ubiquitylation and degradation of receptor-interacting protein 1 (RIP1) and myeloid leukaemia cell differentiation 1 (MCL1), respectively), have important roles in apoptosis.
DUB-le Trouble for Cell Survival.
Memphis, United States. In Cancer Cell, 2010
A recent paper in Nature identified USP9X as an antagonist of MCL-1 ubiquitinylation and degradation.