Time-resolved fluorescence anisotropy imaging.
London, United Kingdom. In Methods Mol Biol, 2013
Polarization-resolved fluorescence lifetime imaging-time-resolved fluorescence anisotropy imaging, TR-FAIM-allows mapping of viscosity or binding or of homo-FRET which can indicate dimerization or generally oligomerization.
TOSO promotes β-cell proliferation and protects from apoptosis.
Bremen, Germany. In Mol Metab, 2011
Here we show that switching off the Fas pathway using Fas apoptotic inhibitory protein (Faim/TOSO), which regulates apoptosis upstream of caspase 8, blocked β-cell apoptosis and increased proliferation in human islets.
Time-resolved fluorescence microscopy.
London, United Kingdom. In Photochem Photobiol Sci, 2005
Fluorescence lifetime imaging (FLIM) can report on photophysical events that are difficult or impossible to observe by fluorescence intensity imaging, and time-resolved fluorescence anisotropy imaging (TR-FAIM) can measure the rotational mobility of a fluorophore in its environment.
Inducible resistance to Fas-mediated apoptosis in B cells.
Boston, United States. In Cell Res, 2000
Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule).