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Fatty acid desaturase 3

FADS3, fatty acid desaturase 3
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, delta-6-desaturase, FADS1, Tec, CAN
Papers on FADS3
Genomic structural analysis of porcine fatty acid desaturase cluster on chromosome 2.
Mikawa et al., Tsukuba, Japan. In Anim Sci J, Apr 2015
The genomic structure of FADS family in mammals consists of three isoforms FADS1, FADS2 and FADS3.
Fatty acid desaturase 1 gene polymorphisms control human hepatic lipid composition.
Liu et al., West Lafayette, United States. In Hepatology, 2015
The potential function of these SNPs in regulating transcription of three FADS genes (FADS1, FADS2, and FADS3) in the locus was also investigated.
Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation.
Vohl et al., Québec, Canada. In Genes Nutr, 2014
Twenty-eight SNPs from FADS1, FADS2, FADS3, ELOVL2 and ELOVL5 were genotyped using TaqMan technology.
Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 diabetes in Chinese Hans.
Li et al., Hangzhou, China. In Nutrition, 2014
Minor allele homozygotes and heterozygotes of rs174455 in FADS3 gene had lower levels of 22:5 ω-3, 20:4 ω-6, and Δ5desaturase activity in patients with T2DM.
Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
Corvera et al., Worcester, United States. In J Biol Chem, 2014
cDNA microarrays analyzed to identify genes correlating with insulin-stimulated sprouting surprisingly revealed only four positively correlating (Fads3, Tmsb10, Depdc6, and Rasl12) and four negatively correlating (Asph, IGFbp4, Ppm1b, and Adcyap1r1) genes.
Unsaturated fatty acids, desaturases, and human health.
Park et al., Ch'ŏnan, South Korea. In J Med Food, 2014
The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.
The 51 kDa FADS3 is secreted in the ECM of hepatocytes and blood in rat.
Pédrono et al., Rennes, France. In J Cell Biochem, 2014
The fatty acid desaturase (Fads) cluster is composed of three genes encoding for the Δ5- and Δ6-desaturases and FADS3.
Detection and molecular characterization of two FAD3 genes controlling linolenic acid content and development of allele-specific markers in yellow mustard (Sinapis alba).
Cheng et al., Saskatoon, Canada. In Plos One, 2013
Inheritance studies detected two fatty acid desaturase 3 (FAD3) gene loci controlling the variation of C18∶3 content.
Trans-vaccenate is Δ13-desaturated by FADS3 in rodents.
Legrand et al., Rennes, France. In J Lipid Res, 2013
However, the function of the mammalian fatty acid desaturase 3 (FADS3) gene remains unknown.
Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets.
Brenna et al., Boston, United States. In Prostaglandins Leukot Essent Fatty Acids, 2013
The objective of the current study was to determine regulation of liver Fads1, Fads2 and Fads3 classical (CS) and alternative transcripts (AT) expression by dietary ARA and DHA, within the physiological range present in human breast milk, in suckling piglets.
Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men.
Lee et al., Seoul, South Korea. In Clin Interv Aging, 2012
METHODS: We genotyped 122 nonobese men aged 35-59 years without any known diseases at baseline for rs174537 near FADS1 (FEN1 rs174537G > T), FADS2 (rs174575, rs2727270), and FADS3 (rs1000778), and followed them for 3 years.
Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health.
Koletzko et al., München, Germany. In Matern Child Nutr, 2011
it is highly likely that a gene product of FADS3 has desaturating activity.
Fatty Acid Desaturase 3 (Fads3) is a singular member of the Fads cluster.
Pédrono et al., Rennes, France. In Biochimie, 2011
Since its identification in 2000, no function has been attributed to the Fatty Acid Desaturase 3 (Fads3) gene.
The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues.
Legrand et al., Rennes, France. In J Lipid Res, 2010
FADS3 does exist under multiple protein isoforms depending on the mammalian tissues.
A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.
Pajukanta et al., Los Angeles, United States. In Plos Genet, 2009
USF1 and FADS3 are causal candidate genes for the Mexican familial combined hyperlipidemia.
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
ENGAGE Consortium et al., Rotterdam, Netherlands. In Nat Genet, 2009
The six newly identified loci in our cohort samples are ABCG5 (TC, P = 1.5 x 10(-11); LDL, P = 2.6 x 10(-10)), TMEM57 (TC, P = 5.4 x 10(-10)), CTCF-PRMT8 region (HDL, P = 8.3 x 10(-16)), DNAH11 (LDL, P = 6.1 x 10(-9)), FADS3-FADS2 (TC, P = 1.5 x 10(-10); LDL, P = 4.4 x 10(-13)) and MADD-FOLH1 region (HDL, P = 6 x 10(-11)).
Common variants at 30 loci contribute to polygenic dyslipidemia.
Cupples et al., Boston, United States. In Nat Genet, 2009
The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP.
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