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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fibronectin type III domain containing 3B

FAD104, FNDC3B, factor for adipocyte differentiation-104, fibronectin type III domain containing 3B
Top mentioned proteins: HAD, fibronectin, Presenilin-1, CAN, FOXO1
Papers on FAD104
Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells.
New
Langmoen et al., Oslo, Norway. In Oncotarget, Oct 2015
Bioinformatic filtering identified 20 genes (PBK/TOPK, CENPA, KIF15, DEPDC1, CDC6, DLG7/DLGAP5/HURP, KIF18A, EZH2, HMMR/RHAMM/CD168, NOL4, MPP6, MDM1, RAPGEF4, RHBDD1, FNDC3B, FILIP1L, MCC, ATXN7L4/ATXN7L1, P2RY5/LPAR6 and FAM118A) that were consistently expressed in GSC cultures and consistently not expressed in NSC cultures.
A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland.
New
Xu et al., Nanchang, China. In Mol Neurobiol, Aug 2015
We revealed that among the 22 potential loci implicated, PRDM2/KIAA1026 (kgp8090149), TSG1/MANEA (kgp154172), PDE10A (kgp8130520), MDGA2 (rs9323124), ATPBD4/LOC100288892 (kgp11333367), ZFP64/TSHZ2 (kgp4156164), PAQR3/ARD1B (kgp9482779), FLJ23172/FNDC3B (kgp760898), C18orf1 (kgp348599), FLJ43860/NCRNA00051 (kgp4105983), CYP1B1/C2orf58 (kgp11353523), WNT9A/LOC728728 (rs849898), ANXA1/LOC100130911 (rs10746953), FLJ35379/LOC100132423 (kgp9550589), PLEKHN1 (kgp7172368), DMRT2/SMARCA2 (kgp10769919), ZNF396/INO80C (rs1362858), C3orf67/LOC339902 (rs6783485), LOC285194/IGSF11 (rs1879553), FGF10/MRPS30 (rs13153459), BARX1/PTPDC1 (kgp6542803), and COL5 A2 (rs11186), the peak significance was at the kgp4105983 of FLJ43860 gene in chromosome 8, the first top strongest associated locus with sPD was PRDM2 (kgp8090149) in chromosome 1, and the 24 pathways including 100 significantly associated genes were strongly associated with sPD from HPCM.
An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma.
New
Jiang et al., Shanghai, China. In Mol Med Report, Jul 2015
Of the genes differentially expressed between the two groups, miRNA-181a, miRNA-202, miRNA-155, FNDC3B, BNC2 and MBD2 were the most significantly altered and may be important in the regulatory network.
Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population.
New
Wang et al., Qingdao, China. In Ophthalmic Genet, Jun 2015
SNPs rs4954218 (Near RAB3GAP1 (5')), rs4894535 (FNDC3B), rs2956540 (LOX), rs3735520 (Near HGF (5')), rs1324183 (MPDZ-NF1B), rs1536482 (RXRA-COL5A1), rs7044529 (COL5A1), rs2721051 (Near FOXO1 (3')), rs9938149 (BANP-ZNF469) and rs6050307 (VSX1) were assessed for their association with KC.
Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of melanoma cells by inhibition of STAT3 activity.
Imagawa et al., Nagoya, Japan. In Plos One, 2014
Previously, we reported that fad104 (factor for adipocyte differentiation 104), a regulatory factor of adipogenesis, regulates cell adhesion and migration.
Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population.
Liu et al., Riyadh, Saudi Arabia. In J Negat Results Biomed, 2014
Association has recently been suggested between KC and 8 single nucleotide polymorphisms (SNPs) in the genomic regions of FNDC3B, COL4A3, MPDZ-NF1B, RXRA-COL5A1, LCN12-PTGDS, FOXO1, and BANP-ZNF469.
DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma.
Hauser et al., Durham, United States. In Invest Ophthalmol Vis Sci, 2014
We further limited our investigation to CNVs in known POAG-related genes, including CDKN2B-AS1, TMCO1, SIX1/SIX6, CAV1/CAV2, the LRP12-ZFPM2 region, GAS7, ATOH7, FNDC3B, CYP1B1, MYOC, OPTN, WDR36, SRBD1, TBK1, and GALC.
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
Impact
Aung et al., London, United Kingdom. In Nat Genet, 2014
within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2
Comparison of stem/progenitor cell number and transcriptomic profile in the mammary tissue of dairy and beef breed heifers.
Motyl et al., Warsaw, Poland. In J Appl Genet, 2014
For the identification and quantification of putative stem/progenitor cells in mammary tissue sections, scanning cytometry was used with a combination of MaSC molecular markers: stem cell antigen-1 (Sca-1) and fibronectin type III domain containing 3B (FNDC3B) protein.
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.
Wu et al., Boston, United States. In Blood, 2014
Long-lived cytotoxic T-cell responses were detected against peptides generated from personal tumor mutations in ALMS1, C6ORF89, and FNDC3B presented on tumor cells.
Gene set enrichment analysis of the NF-κB/Snail/YY1/RKIP circuitry in multiple myeloma.
Spandidos et al., Irákleion, Greece. In Tumour Biol, 2014
Among many, we highlighted on FNDC3B, TPD52, BBX, MBNL1 and MFAP2.
Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.
Chinnaiyan et al., Guangzhou, China. In Am J Pathol, 2014
Transcriptome analysis revealed novel gene fusion candidates, including ANKRD28-FNDC3B.
Evaluating the association between keratoconus and the corneal thickness genes in an independent Australian population.
Baird et al., Melbourne, Australia. In Invest Ophthalmol Vis Sci, 2013
The following six single-nucleotide polymorphisms (SNPs) that showed a statistically significant association with KC in a recent GWAS study were selected for genotyping in our cohort: rs4894535 (FNDC3B), rs1324183 (MPDZ-NF1B), rs1536482 (RXRA-COL5A1), rs7044529 (COL5A), rs2721051 (FOXO1), and rs9938149 (BANP-ZNF469).
Estrogen-responsive genes overlap with triiodothyronine-responsive genes in a breast carcinoma cell line.
Nogueira et al., Botucatu, Brazil. In Scientificworldjournal, 2013
Specifically, we found eight genes that were differentially expressed after treatment with both E₂ and T₃, including amphiregulin, fibulin 1, claudin 6, pericentriolar material 1, premature ovarian failure 1B, factor for adipocyte differentiation-104, sterile alpha motif domain containing 9, and likely ortholog of rat vacuole membrane protein 1 (fold change > 2.0, pFDR < 0.05).
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
Impact
Wong et al., Brisbane, Australia. In Nat Genet, 2013
We further showed that 2 CCT-associated loci, FOXO1 and FNDC3B, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4-1.88,
Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3B.
GeneRIF
Powers et al., United States. In Cell Cycle, 2012
FNDC3B amplification is involved in tumor maintenance in addition to its ability to promote cancer.
Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.
GeneRIF
Imagawa et al., Nagoya, Japan. In Exp Cell Res, 2011
Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation
Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation.
GeneRIF
Imagawa et al., Nagoya, Japan. In Biochem Biophys Res Commun, 2010
fad104 reciprocally regulates differentiation of adipocytes and osteoblast; functions as a positive regulator in adipocyte differentiation and as a negative regulator in osteoblast differentiation.
Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression.
GeneRIF
Sun et al., Shanghai, China. In Hepatology, 2009
Up-regulation of miR-143 expression transcribed by NF-kappaB in hepatitis B virus-related hepatocellular carcinoma promotes cancer cell invasion/migration and tumor metastasis by repression of FNDC3B expression.
Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration.
GeneRIF
Imagawa et al., Nagoya, Japan. In Exp Cell Res, 2009
Fad104 is essential for the survival of newborns just after birth and important for cell proliferation, adhesion, spreading and migration.
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