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Coagulation factor XIII, A1 polypeptide

factor XIIIa, F13A1, F13A
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CD34, Transglutaminase, CAN, S-100
Papers using factor XIIIa antibodies
Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension
Supplier
Hamaoka Kenji et al., In Nephron Extra, 2008
... the F13A treatment group were injected intraperitoneally once a day with a daily dose of 150 μg/kg F13A (Phoenix Pharmaceuticals Inc., Burlingame, Calif., USA) ...
Papers on factor XIIIa
Paracoccidioides brasiliensis interacts with dermal dendritic cells and keratinocytes in human skin and oral mucosa lesions.
New
Sotto et al., São Paulo, Brazil. In Med Mycol, Feb 2016
The biopsies were subjected to immunohistochemical and/or immunofluorescence staining with anti-factor XIIIa (marker of dermal dendrocytes), anti-CD207 (marker of mature Langerhans cells), anti-pan cytokeratins (AE1-AE3) and anti-P.
Central apelin mediates stress-induced gastrointestinal motor dysfunction in rats.
New
Tanrıöver et al., In Am J Physiol Gastrointest Liver Physiol, Jan 2016
Prior to solid gastric emptying (GE) and colon transit (CT) measurements, APJ receptor antagonist F13A was centrally administered under NS conditions and following AS (acute stress), CHS (chronic homotypic stress) and CHeS (chronic heterotypic stress).
Coagulation Factor XIIIA (F13A1): novel perspectives in treatment and pharmacogenetics.
New
Luisa et al., Ferrara, Italy. In Curr Pharm Des, Jan 2016
UNASSIGNED: Factor XIII (FXIII) is a key molecule in the field of blood coagulation and in the last decades it has weakened attention within the field of angiogenesis and tissue repair.
[About a case of calcifying fibrous tumor of the pleura].
New
Chalabreysse et al., Bron, France. In Ann Pathol, Dec 2015
They stain positively for antibodies against vimentin, factor XIIIa, CD68, CD163, CD34.
Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients.
New
Quaresma et al., Belém, Brazil. In Microb Pathog, Dec 2015
To analyze the presence of epidermal dendritic cells (CD1a and CD207), plasmacytoid dendritic cells (CD123) and dermal dendrocytes (factor XIIIa) in lesion fragments of leprosy patients, skin samples from 30 patients were studied.
[Identification of genetic defects in a Chinese pedigree with factor XIII deficiency: case report and literature review].
Review
New
Wang et al., Shanghai, China. In Zhonghua Xue Ye Xue Za Zhi, Oct 2015
OBJECTIVE: To perform phenotypic diagnosis, genetic diagnosis and prenatal diagnosis of inherited coagulation factor XIII (FXIII)deficiency in a Chinese family also provide a review of inherited coagulation F XIII deficiency.
[Transglutaminase and neurodegenerative diseases].
Review
New
Wang et al., Changsha, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Aug 2015
The TGase family found in rodents and human contains 9 types, including TG1-7, blood coagulation factor XIIIa and erythrocyte membrane protein 4.2, with the former 8 types possessing catalytic activity.
Use of a novel floxed mouse to characterise the cellular source of plasma coagulation FXIII-A.
New
Impact
Grant et al., Montréal, Canada. In Lancet, Mar 2015
BACKGROUND: Coagulation factor XIII-A has a crucial role in thrombus stabilisation and tissue repair.
Coagulation factor XIII deficiency. Diagnosis, prevalence and management of inherited and acquired forms.
Review
Oldenburg et al., Bonn, Germany. In Hamostaseologie, 2013
The plasma circulating zymogenic coagulation factor XIII (FXIII) is a protransglutaminase, which upon activation by thrombin and calcium cross-links preformed fibrin clots/fibrinolytic inhibitors making them mechanically stable and less susceptible to fibrinolysis.
Juvenile xanthogranulomas of the nervous system: A report of two cases and review of the literature.
Review
Cope-Yokoyama et al., Loma Linda, United States. In Neuropathology, 2013
The pathologic differential diagnosis includes a heterogeneous group of histiocytic proliferations; immunostaining for histiocytic markers CD68, factor XIIIa, and Fascin, and the absence of Birbeck granules and CD1a immunoexpression suggests the diagnosis of JXG.
Androgen levels and metabolic parameters are associated with a genetic variant of F13A1 in women with polycystic ovary syndrome.
GeneRIF
Obermayer-Pietsch et al., Graz, Austria. In Gene, 2012
F13A1 single nucleotide polymorphism is associated with polycystic ovary syndrome.
Expression of coagulation factor XIII subunit A in acute promyelocytic leukemia.
GeneRIF
Kappelmayer et al., Debrecen, Hungary. In Cytometry B Clin Cytom, 2012
a nocvel expression site of FXIII-A in acute promyelocytic leukemia M3 can be considered as a leukemia associated immunophenotype and may have pathophysiological significance.
Factor XIII plasma levels in women with unexplained recurrent pregnancy loss.
GeneRIF
Schroeder et al., In J Thromb Haemost, 2012
Letter: suggest that recurrent pregnancy loss in the general population is not associated with reduced FXIII plasma levels.
Comparative analysis of secreted proteins from normal and preeclamptic trophoblastic cells using proteomic approaches.
GeneRIF
Cohen et al., Genève, Switzerland. In J Proteomics, 2012
data suggest that decrease of factor XIII chain A might be associated with development of preeclampsia
In vivo near-infrared imaging of fibrin deposition in thromboembolic stroke in mice.
GeneRIF
Teng et al., Nanjing, China. In Plos One, 2011
Data indicate that FXIIIa-targeted probe signals showed good overlap with immune-fluorescent fibrin staining images.
Genetic predictors of response to photodynamictherapy.
Review
Incorvaia et al., Ferrara, Italy. In Mol Diagn Ther, 2011
Specifically, correlations between SNPs and different levels of PDT-V efficacy have been detected by examining the gene variants influencing (i) thrombo-coagulative pathways, i.e. methylenetetrahydrofolate reductase (MTHFR) 677C>T (rs1801133), factor V (F5) 1691G>A (rs6025), prothrombin (F2) 20210G>A (rs1799963), and factor XIII-A (F13A1) 185G>T (rs5985); (ii) complement activation and/or inflammatory processes, i.e. complement factor H (CFH) 1277T>C (rs1061170), high-temperature requirement factor A1 (HTRA1) promoter -512G>A (rs11200638), and two variants of the C-reactive protein (CRP) gene (rs2808635 and rs876538); and (iii) production and bioavailability of vascular endothelial growth factor (VEGFA -2578C>A [rs699947] and rs2146323).
Factor XIIIA (cross)links AT1 receptors to atherosclerosis.
Impact
Glass et al., San Diego, United States. In Cell, 2004
In this issue of Cell, AbdAlla et al. (2004) provide evidence that pathogenic actions of angiotensin II involve covalent crosslinking of angiotensin AT1 receptors by factor XIIIA transglutaminase, resulting in stable receptor dimers with enhanced signaling properties.
Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis.
Impact
Quitterer et al., Hamburg, Germany. In Cell, 2004
We report here that intracellular factor XIIIA transglutaminase crosslinks agonist-induced AT1 receptor homodimers via glutamine315 in the carboxyl-terminal tail of the AT1 receptor.
Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22.
Impact
Diehl et al., Bethesda, United States. In Nat Genet, 1995
A multipoint lod score of 3.9 (P = 2.3 x 10(-5)) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity.
Binding and factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus.
Impact
Proctor et al., In Science, 1980
A 27-kilodalton tryptic fragment, derived from the amino terminus of the 200-kilodalton fibronectin subunit, inhibited binding of intact fibronectin to Staphylococcus aureus and could be cross-linked to Staphylococcus aureus by blood coagulation Factor XIIIa.
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